CACNA1A and PMM1

Number of citations of the paper that reports this interaction (PubMedID 21078624)
125

Data Source:
BioGRID (two hybrid)

		CACNA1A	PMM1
Description		calcium voltage-gated channel subunit alpha1 A	phosphomannomutase 1
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GO Annotations	Cellular Component	Nucleus Cytoplasm Plasma Membrane Voltage-gated Calcium Channel Complex Membrane Monoatomic Ion Channel Complex Cell Projection Neuronal Cell Body Synapse	Cytoplasm Cytosol Neuronal Cell Body
	Molecular Function	Amyloid-beta Binding Monoatomic Ion Channel Activity Voltage-gated Calcium Channel Activity Calcium Channel Activity Protein Binding High Voltage-gated Calcium Channel Activity Syntaxin Binding Metal Ion Binding	Phosphomannomutase Activity Protein Binding Isomerase Activity Metal Ion Binding
	Biological Process	Monoatomic Ion Transport Calcium Ion Transport Positive Regulation Of Cytosolic Calcium Ion Concentration Chemical Synaptic Transmission Monoatomic Ion Transmembrane Transport Modulation Of Chemical Synaptic Transmission Transmembrane Transport Calcium Ion Transmembrane Transport Calcium Ion Import Across Plasma Membrane Response To Amyloid-beta Cellular Response To Amyloid-beta	Mannose Metabolic Process Protein N-linked Glycosylation GDP-mannose Biosynthetic Process Nucleoside Phosphate Biosynthetic Process Cellular Response To Leukemia Inhibitory Factor
Pathways		Presynaptic depolarization and calcium channel opening Regulation of insulin secretion	Synthesis of GDP-mannose
Drugs		Ergocalciferol Enflurane Phenytoin Spironolactone Nicardipine Magnesium sulfate Verapamil Verapamil Levomenthol Loperamide Nitrendipine Bepridil Ziconotide Dotarizine Drotaverine Trimebutine Benidipine Cilnidipine Efonidipine Lacidipine Manidipine Butamben Bioallethrin Bioallethrin Bioallethrin
Diseases		Spinocerebellar ataxia (SCA); Machado-Joseph disease (SCA3) Episodic ataxias Familial or sporadic hemiplegic migraine
GWAS		Exfoliation syndrome ( 25706626) Proteinuria and chronic kidney disease ( 26420894)	Crohn's disease ( 26192919) Inflammatory bowel disease ( 26192919) Meat-related diet ( 32066663) Neuroticism ( 29255261) Refractive error ( 32231278)
Interacting Genes		92 interacting genes: ABCA2 ABI1 ACTN1 ADGRL1 AGRN ALDOA AMIGO2 AP2M1 ARHGAP22 BTG3 C1QTNF1 CABP1 CACNB1 CACNB4 CALM2 CALM3 CKAP5 CRIM1 CRMP1 CSNK2B CYSRT1 DNAJB5 EFEMP1 EFEMP2 EHMT2 EIF3A FBLN1 GET3 GNB1 GOLGA6L5P GRN HECW1 HHATL HIVEP1 HSPG2 IP6K1 JAG2 KALRN KHDRBS3 KIAA1191 LAMB1 LLGL1 LRP1 LTBP1 LTBP3 LTBP4 MANBAL MATK MATN2 MEGF6 MEGF8 MIA3 MOAP1 NDUFB8 NELFCD NELL1 NELL2 NOTCH1 NOXA1 OLIG1 PCSK5 PCSK6 PMM1 PPIG PPM1A PPP1R12C PTGDS PUF60 RBM12B RIMBP2 RPL31 RPS17 SCP2 SPRY1 SRRM4 SRSF1 SUMF2 SYT1 TAF15 TELO2 TSC22D1 TSPAN7 TSPOAP1 TUBB2B UQCRC2 VARS1 VPS52 VWF WBP1 YLPM1 ZCCHC17 ZNF233	5 interacting genes: CACNA1A MFHAS1 RAB6A RAB6B RCHY1
Entrez ID		773	5372
HPRD ID		03004	03473
Ensembl ID		ENSG00000141837	ENSG00000100417
Uniprot IDs		A0A087WW63 B5TYJ1 O00555 Q9NS89	Q92871
PDB IDs		3BXK 8X90 8X91 8X93	2FUC 2FUE 6CFR 6CFS 6CFT 6CFU 6CFV
Enriched GO Terms of Interacting Partners?		Calcium Ion Binding Extracellular Matrix Structural Constituent Extracellular Matrix Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Embryo Implantation Calcium Channel Regulator Activity Basement Membrane Microfibril Voltage-gated Calcium Channel Activity Involved In Regulation Of Presynaptic Cytosolic Calcium Levels Detection Of Calcium Ion Auditory Receptor Cell Fate Commitment Protein Binding Calyx Of Held Integrin Binding Astrocyte Activation Involved In Immune Response Transforming Growth Factor Beta Binding Extracellular Region Negative Regulation Of Calcium Ion Export Across Plasma Membrane Adenylate Cyclase Activator Activity Elastic Fiber Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Enzyme Inhibitor Activity Low-density Lipoprotein Particle Receptor Binding Transporter Inhibitor Activity Regulation Of Calcium Ion Export Across Plasma Membrane Presynaptic Cytosol Regulation Of Cellular Response To Growth Factor Stimulus Negative Regulation Of Cell Population Proliferation Regulation Of Extracellular Matrix Organization Regulation Of Alternative MRNA Splicing, Via Spliceosome	Protein Localization To Golgi Membrane Myosin V Binding Protein Localization To Golgi Apparatus Intra-Golgi Vesicle-mediated Transport Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum GTP Binding Peptidyl-cysteine Methylation Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cytosolic Transport Retrograde Transport, Endosome To Golgi Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Post-translational Protein Modification Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Protein Autoubiquitination Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process VCB Complex Positive Regulation Of Protein Ubiquitination Positive Regulation Of Proteasomal Protein Catabolic Process Minus-end-directed Organelle Transport Along Microtubule NEDD8 Ligase Activity Cul7-RING Ubiquitin Ligase Complex Negative Regulation Of Toll-like Receptor 2 Signaling Pathway Regulation Of Ubiquitin-dependent Protein Catabolic Process Base-excision Repair, AP Site Formation Via Deaminated Base Removal NEDD8 Transferase Activity Error-free Translesion Synthesis Positive Regulation Of Proteolysis Regulation Of Proteasomal Protein Catabolic Process Regulation Of Protein Autoubiquitination Regulation Of Protein Ubiquitination Cul4B-RING E3 Ubiquitin Ligase Complex Positive Regulation Of Protein Catabolic Process Positive Regulation Of Toll-like Receptor 2 Signaling Pathway Regulation Of Post-translational Protein Modification Negative Regulation Of Response To Oxidative Stress Ubiquitin-protein Transferase Activity Endosomal Transport Endomembrane System Golgi Vesicle Transport Ubiquitin-dependent Protein Catabolic Process Via The C-end Degron Rule Pathway Negative Regulation Of Mitophagy Transcription-coupled Nucleotide-excision Repair High Voltage-gated Calcium Channel Activity Protein Localization To Membrane Ubiquitin Protein Ligase Binding GTPase Activity Ciliary Basal Body Cul4A-RING E3 Ubiquitin Ligase Complex Negative Regulation Of Toll-like Receptor 4 Signaling Pathway
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