CACNA1A and SCP2

Number of citations of the paper that reports this interaction (PubMedID 21078624)
125

Data Source:
BioGRID (two hybrid)

		CACNA1A	SCP2
Description		calcium voltage-gated channel subunit alpha1 A	sterol carrier protein 2
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GO Annotations	Cellular Component	Nucleus Cytoplasm Plasma Membrane Voltage-gated Calcium Channel Complex Membrane Monoatomic Ion Channel Complex Cell Projection Neuronal Cell Body Synapse	Nucleoplasm Cytoplasm Mitochondrion Peroxisome Peroxisomal Matrix Endoplasmic Reticulum Cytosol Membrane Protein-containing Complex
	Molecular Function	Amyloid-beta Binding Monoatomic Ion Channel Activity Voltage-gated Calcium Channel Activity Calcium Channel Activity Protein Binding High Voltage-gated Calcium Channel Activity Syntaxin Binding Metal Ion Binding	Fatty-acyl-CoA Binding Acetyl-CoA C-acyltransferase Activity Signaling Receptor Binding Protein Binding Lipid Binding Phosphatidylinositol Transfer Activity Cholesterol Binding Transferase Activity Acyltransferase Activity Acyltransferase Activity, Transferring Groups Other Than Amino-acyl Groups Propanoyl-CoA C-acyltransferase Activity Long-chain Fatty Acyl-CoA Binding Propionyl-CoA C2-trimethyltridecanoyltransferase Activity Acetyl-CoA C-myristoyltransferase Activity Oleic Acid Binding Phosphatidylcholine Transfer Activity Cholesterol Transfer Activity
	Biological Process	Monoatomic Ion Transport Calcium Ion Transport Positive Regulation Of Cytosolic Calcium Ion Concentration Chemical Synaptic Transmission Monoatomic Ion Transmembrane Transport Modulation Of Chemical Synaptic Transmission Transmembrane Transport Calcium Ion Transmembrane Transport Calcium Ion Import Across Plasma Membrane Response To Amyloid-beta Cellular Response To Amyloid-beta	Lipid Metabolic Process Fatty Acid Beta-oxidation Unsaturated Fatty Acid Biosynthetic Process Steroid Biosynthetic Process Bile Acid Biosynthetic Process Progesterone Biosynthetic Process Lipid Transport Bile Acid Metabolic Process Phospholipid Transport Sterol Transport Regulation Of Lipid Metabolic Process Intracellular Cholesterol Transport Positive Regulation Of Intracellular Cholesterol Transport Inositol Trisphosphate Biosynthetic Process Fatty Acid Beta-oxidation Using Acyl-CoA Oxidase Alpha-linolenic Acid Metabolic Process Long-chain Fatty Acid Biosynthetic Process Positive Regulation Of Steroid Metabolic Process Regulation Of Phospholipid Biosynthetic Process Protein Localization To Plasma Membrane Intermembrane Lipid Transfer Lipid Hydroperoxide Transport Fatty Acid Derivative Biosynthetic Process
Pathways		Presynaptic depolarization and calcium channel opening Regulation of insulin secretion	alpha-linolenic acid (ALA) metabolism Peroxisomal protein import Peroxisomal protein import TYSND1 cleaves peroxisomal proteins
Drugs		Ergocalciferol Enflurane Phenytoin Spironolactone Nicardipine Magnesium sulfate Verapamil Verapamil Levomenthol Loperamide Nitrendipine Bepridil Ziconotide Dotarizine Drotaverine Trimebutine Benidipine Cilnidipine Efonidipine Lacidipine Manidipine Butamben Bioallethrin Bioallethrin Bioallethrin
Diseases		Spinocerebellar ataxia (SCA); Machado-Joseph disease (SCA3) Episodic ataxias Familial or sporadic hemiplegic migraine	Leukoencephalopathy with dystonia and motor neuropathy Peroxisomal beta-oxidation enzyme deficiency, including: Acyl-CoA oxidase (ACOX) deficiency; D-bifunctional protein (DBP) deficiency; Perrault syndrome; Sterol carrier protein X (SCPx) deficiency; 2-Methylacyl-CoA racemase (AMCR) deficiency; Hypercholanemia
GWAS		Exfoliation syndrome ( 25706626) Proteinuria and chronic kidney disease ( 26420894)
Interacting Genes		92 interacting genes: ABCA2 ABI1 ACTN1 ADGRL1 AGRN ALDOA AMIGO2 AP2M1 ARHGAP22 BTG3 C1QTNF1 CABP1 CACNB1 CACNB4 CALM2 CALM3 CKAP5 CRIM1 CRMP1 CSNK2B CYSRT1 DNAJB5 EFEMP1 EFEMP2 EHMT2 EIF3A FBLN1 GET3 GNB1 GOLGA6L5P GRN HECW1 HHATL HIVEP1 HSPG2 IP6K1 JAG2 KALRN KHDRBS3 KIAA1191 LAMB1 LLGL1 LRP1 LTBP1 LTBP3 LTBP4 MANBAL MATK MATN2 MEGF6 MEGF8 MIA3 MOAP1 NDUFB8 NELFCD NELL1 NELL2 NOTCH1 NOXA1 OLIG1 PCSK5 PCSK6 PMM1 PPIG PPM1A PPP1R12C PTGDS PUF60 RBM12B RIMBP2 RPL31 RPS17 SCP2 SPRY1 SRRM4 SRSF1 SUMF2 SYT1 TAF15 TELO2 TSC22D1 TSPAN7 TSPOAP1 TUBB2B UQCRC2 VARS1 VPS52 VWF WBP1 YLPM1 ZCCHC17 ZNF233	11 interacting genes: ACAA2 ACOX1 CACNA1A CAV1 CEBPA CREB3 EHHADH OGT PEX5 PITPNA TRIP13
Entrez ID		773	6342
HPRD ID		03004	01700
Ensembl ID		ENSG00000141837	ENSG00000116171
Uniprot IDs		A0A087WW63 B5TYJ1 O00555 Q9NS89	A0A384NY87 B2R761 E9PLD1 P22307 Q59HG9
PDB IDs		3BXK 8X90 8X91 8X93	1QND 2C0L
Enriched GO Terms of Interacting Partners?		Calcium Ion Binding Extracellular Matrix Structural Constituent Extracellular Matrix Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Embryo Implantation Calcium Channel Regulator Activity Basement Membrane Microfibril Voltage-gated Calcium Channel Activity Involved In Regulation Of Presynaptic Cytosolic Calcium Levels Detection Of Calcium Ion Auditory Receptor Cell Fate Commitment Protein Binding Calyx Of Held Integrin Binding Astrocyte Activation Involved In Immune Response Transforming Growth Factor Beta Binding Extracellular Region Negative Regulation Of Calcium Ion Export Across Plasma Membrane Adenylate Cyclase Activator Activity Elastic Fiber Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Enzyme Inhibitor Activity Low-density Lipoprotein Particle Receptor Binding Transporter Inhibitor Activity Regulation Of Calcium Ion Export Across Plasma Membrane Presynaptic Cytosol Regulation Of Cellular Response To Growth Factor Stimulus Negative Regulation Of Cell Population Proliferation Regulation Of Extracellular Matrix Organization Regulation Of Alternative MRNA Splicing, Via Spliceosome	Fatty Acid Beta-oxidation Lipid Oxidation Fatty Acid Catabolic Process Fatty Acid Oxidation Lipid Metabolic Process Lipid Modification Peroxisomal Matrix Carboxylic Acid Catabolic Process Lipid Catabolic Process Fatty Acid Metabolic Process Fatty Acid Beta-oxidation Using Acyl-CoA Oxidase Alpha-linolenic Acid Metabolic Process Negative Regulation Of Cellular Component Organization Peroxisome Lipid Homeostasis Monocarboxylic Acid Metabolic Process Regulation Of Necroptotic Process Cellular Response To Stress Long-chain Fatty Acid Biosynthetic Process Very Long-chain Fatty Acid Metabolic Process Positive Regulation Of Proteolysis Regulation Of Proteasomal Protein Catabolic Process Regulation Of Programmed Necrotic Cell Death Integrated Stress Response Signaling Organelle Organization Unsaturated Fatty Acid Biosynthetic Process Fatty Acid Derivative Biosynthetic Process Mitochondrion Organization Very Long-chain Fatty Acid Beta-oxidation Inward Rectifier Potassium Channel Inhibitor Activity Membrane Organization RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Positive Regulation Of Deacetylase Activity Peroxisomal Membrane Carboxylic Acid Metabolic Process Organic Acid Metabolic Process Protein-containing Complex Negative Regulation Of Protein Ubiquitination Fatty Acid Derivative Metabolic Process Small Molecule Metabolic Process Response To Stress Caveolar Macromolecular Signaling Complex Negative Regulation Of Cell Cycle Response To Vitamin B2 C/EBP Complex Long-chain (3S)-3-hydroxyacyl-CoA Dehydrogenase (NAD+) Activity Intramolecular Oxidoreductase Activity, Transposing C=C Bonds Peroxisome Membrane Targeting Sequence Binding
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