RUFY3 and UNC119

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		RUFY3	UNC119
Gene Name		RUN and FYVE domain containing 3	unc-119 homolog (C. elegans)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Filopodium Growth Cone	Spindle Pole Centrosome Cytosol Intercellular Bridge Spindle Midzone
	Molecular Function		Protein Binding Lipid Binding
	Biological Process	Negative Regulation Of Axonogenesis	Endocytosis Cytokinesis, Completion Of Separation Synaptic Transmission Visual Perception Phototransduction Lipoprotein Transport Positive Regulation Of Protein Tyrosine Kinase Activity Negative Regulation Of Clathrin-mediated Endocytosis Negative Regulation Of Caveolin-mediated Endocytosis
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		2 interactors: APP UNC119	92 interactors: AAGAB ALDH2 AMOT ANKRD24 ANXA1 ANXA3 ANXA7 ARL15 ARL2 ARL3 ARL4D ASH2L BCR BRIX1 BTBD2 C16orf74 CBX8 CCL18 CD247 CD3E CD4 CDC42 CDKN1A CDKN2C CETN3 CKMT2 CKS2 COX17 CYB561D2 EIF2S2 ERH FKBPL FXYD6 FYN GIPC2 GSTM4 HCK HLA-DQA1 HMGB1 HSPB3 HSPE1 ID2 IL5RA ITSN1 KDM1A LAMA4 LCK LIG4 LUC7L2 LYN MAPK10 MAPK8IP2 MPHOSPH6 MRPS12 ORAI2 PAFAH1B3 PAPSS1 PCDHA4 PFN1 PHF10 PIN1 PPA1 PPAP2C PSMD11 PSMD2 PTPRS QTRT1 RAP1B RCC1 RFC5 RGL2 RPA2 RPS6KA5 RUFY3 S100A4 S100A8 SAT1 SEPHS1 SERPINB9 SMN1 SULT1E1 TK1 TP53BP2 TP53I3 TRDMT1 TSC22D1 UBE2B UBE2I UBQLN4 ZAK ZFP64 ZNF24
Entrez ID		22902	9094
HPRD ID		15251	04927
Ensembl ID		ENSG00000018189	ENSG00000109103
Uniprot IDs		Q7L099	Q13432
PDB IDs			3GQQ 3RBQ 4GOJ 4GOK
Enriched GO Terms of Interacting Partners?		Regulation Of Protein Tyrosine Kinase Activity Regulation Of Peptidyl-tyrosine Phosphorylation Negative Regulation Of Clathrin-mediated Endocytosis Negative Regulation Of Caveolin-mediated Endocytosis Synaptic Growth At Neuromuscular Junction Response To Light Stimulus Collateral Sprouting In Absence Of Injury Cytokinesis, Completion Of Separation Regulation Of Cellular Amino Acid Metabolic Process Response To Radiation Collateral Sprouting Axon Midline Choice Point Recognition Regulation Of Cellular Ketone Metabolic Process Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Axon Choice Point Recognition Regulation Of Caveolin-mediated Endocytosis Mitotic Cytokinetic Process Neuron Remodeling Endocytosis Regulation Of Clathrin-mediated Endocytosis Regulation Of Protein Kinase Activity Regulation Of Kinase Activity Cellular Copper Ion Homeostasis Cell Separation After Cytokinesis Lipoprotein Transport Negative Regulation Of Receptor-mediated Endocytosis Copper Ion Homeostasis Suckling Behavior Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Protein Phosphorylation Response To Abiotic Stimulus Positive Regulation Of Cellular Protein Metabolic Process Neurological System Process Neuron Maturation MRNA Polyadenylation Regulation Of Epidermal Growth Factor-activated Receptor Activity Positive Regulation Of Protein Metabolic Process Mating Behavior Endoplasmic Reticulum Calcium Ion Homeostasis Positive Regulation Of Protein Tyrosine Kinase Activity RNA Polyadenylation Neuron Recognition Regulation Of Phosphorylation Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Ionotropic Glutamate Receptor Signaling Pathway Mitotic Cytokinesis Vesicle-mediated Transport Regulation Of G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Endocytosis Regulation Of Cell Cycle G2/M Phase Transition	T Cell Costimulation Regulation Of Catalytic Activity Response To Stress Developmental Process Immune System Process Regulation Of Defense Response To Virus By Virus System Development Anatomical Structure Development Positive Regulation Of Catalytic Activity Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Response To Stimulus Immune Response Regulation Of Apoptotic Process Defense Response Cell Cycle Nervous System Development Regulation Of Cellular Protein Metabolic Process Multicellular Organismal Development Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Cell Death Intracellular Signal Transduction Regulation Of Protein Metabolic Process Cellular Response To Stimulus Antigen Receptor-mediated Signaling Pathway Positive Regulation Of Immune System Process Positive Regulation Of Transferase Activity Immune Response-activating Cell Surface Receptor Signaling Pathway Positive Regulation Of T Cell Activation Regulation Of Cell Activation Regulation Of Cell Cycle Innate Immune Response Positive Regulation Of Homotypic Cell-cell Adhesion Positive Regulation Of Cell Activation Regulation Of Lymphocyte Activation Positive Regulation Of Protein Metabolic Process Positive Regulation Of Signal Transduction G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Cellular Metabolic Process Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell-cell Adhesion Leukocyte Differentiation T Cell Receptor Signaling Pathway Regulation Of Cellular Component Organization Positive Regulation Of Protein Modification Process Viral Process Positive Regulation Of Intracellular Signal Transduction Cell Differentiation Positive Regulation Of Metabolic Process Cell Activation
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