RUFY3 and ARL8B

Number of citations of the paper that reports this interaction (PubMedID 36282215)
72

Data Source:
BioGRID (pull down)

		RUFY3	ARL8B
Description		RUN and FYVE domain containing 3	ARF like GTPase 8B
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Lysosome Cytosol Endomembrane System Membrane Lamellipodium Filopodium Axon Dendrite Growth Cone Endolysosome Cell Projection Neuronal Cell Body Perikaryon Anchoring Junction	Cytoplasm Lysosome Lysosomal Membrane Endosome Spindle Cytosol Cytoskeleton Membrane Axon Midbody Early Endosome Membrane Late Endosome Membrane Cell Projection Synapse Spindle Midzone Extracellular Exosome Cytolytic Granule Membrane Axon Cytoplasm
	Molecular Function	Protein Binding Dynactin Binding	Nucleotide Binding GTPase Activity G Protein Activity Protein Binding GTP Binding Hydrolase Activity GDP Binding Alpha-tubulin Binding Beta-tubulin Binding
	Biological Process	Actin Filament Organization Nervous System Development Cell Differentiation Positive Regulation Of Cell Migration Positive Regulation Of Axon Extension Regulation Of Axonogenesis Negative Regulation Of Axonogenesis Positive Regulation Of Intracellular Protein Transport Regulation Of Establishment Of Cell Polarity Positive Regulation Of Retrograde Axon Cargo Transport	Plasma Membrane Repair Antigen Processing And Presentation Of Polysaccharide Antigen Via MHC Class II Antigen Processing And Presentation Following Phagocytosis Chromosome Segregation Anterograde Axonal Transport Protein Transport Endosomal Transport Lysosome Localization Endosomal Vesicle Fusion Early Endosome To Golgi Transport Natural Killer Cell Mediated Cytotoxicity Viral Exocytosis Cell Division Autophagosome-lysosome Fusion Endosome To Lysosome Transport Of Low-density Lipoprotein Particle Phagosome-lysosome Fusion Late Endosome To Lysosome Transport Protein Localization To Early Endosome Calcium Ion Regulated Lysosome Exocytosis
Pathways
Drugs
Diseases
GWAS			Disc degeneration (lumbar) ( 22993228) Fulminant type 1 diabetes ( 30552108) Metabolite levels ( 23823483) Serum alkaline phosphatase levels ( 33547301)
Interacting Genes		7 interacting genes: ABI3 APP ARL8B CAPN3 DSCAM RAB33A UNC119	13 interacting genes: AMH APP ATP5MF BTN3A3 CIDEB DLEU1 RAB14 RUFY3 SLC30A8 TGFBR1 TMEM14B TUBB VPS41
Entrez ID		22902	55207
HPRD ID		15251	12483
Ensembl ID		ENSG00000018189	ENSG00000134108
Uniprot IDs		B4DG59 B4DKC2 Q7L099	Q9NVJ2
PDB IDs			2AL7 8JC5 8JCA
Enriched GO Terms of Interacting Partners?		Amyloid-beta Complex Cell Projection Morphogenesis Dendritic Shaft Axon Positive Regulation Of Phosphate Metabolic Process Growth Cone Lamellipodium Trans-synaptic Signaling Chemical Synaptic Transmission Regulation Of Response To Calcium Ion Regulation Of Developmental Growth Amylin Binding Positive Regulation Of Toll Signaling Pathway Neuron Recognition Synaptic Signaling Synapse Synapse Organization Calcium-dependent Self Proteolysis Spindle Midzone Antigen Processing And Presentation Following Phagocytosis Antigen Processing And Presentation Of Polysaccharide Antigen Via MHC Class II Viral Exocytosis Axo-dendritic Transport Acetylcholine Receptor Activator Activity Lipoprotein Particle Cell Junction Organization Positive Regulation Of Protein Import Ligase Regulator Activity Positive Regulation Of Satellite Cell Activation Involved In Skeletal Muscle Regeneration Post-embryonic Retina Morphogenesis In Camera-type Eye Netrin Receptor Binding Negative Regulation Of Caveolin-mediated Endocytosis Antigen Processing And Presentation Endosome To Lysosome Transport Of Low-density Lipoprotein Particle PTB Domain Binding Regulation Of Phosphorus Metabolic Process Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Cell Recognition Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Regulation Of Receptor-mediated Endocytosis Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Regulation Of Satellite Cell Activation Involved In Skeletal Muscle Regeneration Calcium Ion Regulated Lysosome Exocytosis Protein Localization To Early Endosome Cell-cell Signaling Regulation Of Growth	Type II Transforming Growth Factor Beta Receptor Binding Nuclear Envelope Lumen Golgi-associated Vesicle Endosomal Vesicle Fusion Organelle Fusion Signaling Receptor Binding Cytoplasmic Vesicle Positive Regulation Of SMAD Protein Signal Transduction System Development Membrane Raft Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Early Endosome Membrane Lysosome Amylin Binding Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Protein Transport
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