RUFY3 and CAPN3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		RUFY3	CAPN3
Description		RUN and FYVE domain containing 3	calpain 3
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Lysosome Cytosol Endomembrane System Membrane Lamellipodium Filopodium Axon Dendrite Growth Cone Endolysosome Cell Projection Neuronal Cell Body Perikaryon Anchoring Junction	Nucleus Nucleolus Cytoplasm Cytosol Plasma Membrane Myofibril Z Disc T-tubule Protein-containing Complex
	Molecular Function	Protein Binding Dynactin Binding	Catalytic Activity Calcium-dependent Cysteine-type Endopeptidase Activity Calcium Ion Binding Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Structural Constituent Of Muscle Hydrolase Activity Sodium Ion Binding Titin Binding Identical Protein Binding Metal Ion Binding Ligase Regulator Activity Molecular Adaptor Activity
	Biological Process	Actin Filament Organization Nervous System Development Cell Differentiation Positive Regulation Of Cell Migration Positive Regulation Of Axon Extension Regulation Of Axonogenesis Negative Regulation Of Axonogenesis Positive Regulation Of Intracellular Protein Transport Regulation Of Establishment Of Cell Polarity Positive Regulation Of Retrograde Axon Cargo Transport	Proteolysis Apoptotic Process Muscle Organ Development Programmed Cell Death Positive Regulation Of Satellite Cell Activation Involved In Skeletal Muscle Regeneration Response To Muscle Activity Protein Catabolic Process Myofibril Assembly Protein Destabilization Negative Regulation Of Protein Sumoylation Negative Regulation Of Apoptotic Process Regulation Of Canonical NF-kappaB Signal Transduction Sarcomere Organization Regulation Of Myoblast Differentiation Positive Regulation Of Proteolysis Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Muscle Cell Cellular Homeostasis Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Response To Calcium Ion Muscle Structure Development Protein-containing Complex Assembly G1 To G0 Transition Involved In Cell Differentiation Cellular Response To Calcium Ion Cellular Response To Salt Stress Protein Localization To Membrane Self Proteolysis Calcium-dependent Self Proteolysis
Pathways			Degradation of the extracellular matrix
Drugs			L-aminocarnityl-succinyl-leucyl-argininal-diethylacetal
Diseases			Limb-girdle muscular dystrophy (LGMD) Calpainopathy; Limb-girdle muscular dystrophy 2A (LGMD2A)
GWAS			Fibrinogen levels ( 26561523 28107422) Granulocyte percentage of myeloid white cells ( 27863252) HDL cholesterol levels ( 30698716) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Metabolite levels ( 23823483) Monocyte count ( 27863252 32888494) Monocyte percentage of white cells ( 27863252 32888494) Triglyceride levels ( 30698716 32203549) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Triglyceride levels x short total sleep time interaction (2df test) ( 31719535) Triglycerides ( 25961943 24097068 20686565)
Interacting Genes		7 interacting genes: ABI3 APP ARL8B CAPN3 DSCAM RAB33A UNC119	32 interacting genes: AMOT C1QTNF9 CCDC102B CEP76 CMYA5 CRYAB DYSF EXOC8 FLNC FNDC3B FXR1 GTPBP3 KANK2 MAP1LC3C MMP2 MYBPC1 MYBPH NECAB2 NTAQ1 OSGIN1 POMP PREPL PSMC3 PSMD1 RNF167 RUFY3 TFCP2 TRIM55 TRIM63 TTN UBE3A YWHAQ
Entrez ID		22902	825
HPRD ID		15251	00255
Ensembl ID		ENSG00000018189	ENSG00000092529
Uniprot IDs		B4DG59 B4DKC2 Q7L099	A0A0S2Z3E1 P20807
PDB IDs			4OKH 6BDT 6BGP 6BJD 6BKJ
Enriched GO Terms of Interacting Partners?		Amyloid-beta Complex Cell Projection Morphogenesis Dendritic Shaft Axon Positive Regulation Of Phosphate Metabolic Process Growth Cone Lamellipodium Trans-synaptic Signaling Chemical Synaptic Transmission Regulation Of Response To Calcium Ion Regulation Of Developmental Growth Amylin Binding Positive Regulation Of Toll Signaling Pathway Neuron Recognition Synaptic Signaling Synapse Synapse Organization Calcium-dependent Self Proteolysis Spindle Midzone Antigen Processing And Presentation Following Phagocytosis Antigen Processing And Presentation Of Polysaccharide Antigen Via MHC Class II Viral Exocytosis Axo-dendritic Transport Acetylcholine Receptor Activator Activity Lipoprotein Particle Cell Junction Organization Positive Regulation Of Protein Import Ligase Regulator Activity Positive Regulation Of Satellite Cell Activation Involved In Skeletal Muscle Regeneration Post-embryonic Retina Morphogenesis In Camera-type Eye Netrin Receptor Binding Negative Regulation Of Caveolin-mediated Endocytosis Antigen Processing And Presentation Endosome To Lysosome Transport Of Low-density Lipoprotein Particle PTB Domain Binding Regulation Of Phosphorus Metabolic Process Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Cell Recognition Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Regulation Of Receptor-mediated Endocytosis Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Regulation Of Satellite Cell Activation Involved In Skeletal Muscle Regeneration Calcium Ion Regulated Lysosome Exocytosis Protein Localization To Early Endosome Cell-cell Signaling Regulation Of Growth	M Band Sarcomere Organization Cytoplasm Actomyosin Structure Organization Structural Constituent Of Muscle Z Disc Endomembrane System Contractile Muscle Fiber Titin Binding Proteasome Regulatory Particle, Base Subcomplex Proteasome Complex Cytoskeletal Protein Binding Costamere Proteasome Accessory Complex Actin Cytoskeleton Organization
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