TNFRSF11A and TRAF1

Number of citations of the paper that reports this interaction (PMID 9774460)
65

Data Source:
HPRD (in vivo, in vitro)

		TNFRSF11A	TRAF1
Gene Name		tumor necrosis factor receptor superfamily, member 11a, NFKB activator	TNF receptor-associated factor 1
Image
Gene Ontology Annotations	Cellular Component	External Side Of Plasma Membrane Integral Component Of Membrane	Cytoplasm
	Molecular Function	Receptor Activity Transmembrane Signaling Receptor Activity Tumor Necrosis Factor-activated Receptor Activity Protein Binding Cytokine Binding Metal Ion Binding	Tumor Necrosis Factor Receptor Binding Protein Binding Zinc Ion Binding Ubiquitin Protein Ligase Binding Thioesterase Binding
	Biological Process	Ossification Adaptive Immune Response Monocyte Chemotaxis Signal Transduction Cell-cell Signaling Positive Regulation Of Cell Proliferation Response To Radiation Osteoclast Differentiation Response To Lipopolysaccharide Tumor Necrosis Factor-mediated Signaling Pathway Response To Cytokine Response To Tumor Necrosis Factor Positive Regulation Of JUN Kinase Activity Lymph Node Development Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Circadian Temperature Homeostasis Mammary Gland Alveolus Development Response To Interleukin-1 Positive Regulation Of Fever Generation By Positive Regulation Of Prostaglandin Secretion TNFSF11-mediated Signaling Pathway Positive Regulation Of ERK1 And ERK2 Cascade Via TNFSF11-mediated Signaling	Protein Complex Assembly Apoptotic Process Signal Transduction Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways
Drugs
Diseases
GWAS		Bone mineral density ( 22504420) Bone mineral density (spine) ( 19801982) Paget's disease ( 21623375 20436471) Response to antipsychotic treatment ( 23241943) Serum albumin level ( 23022100)	Celiac disease and Rheumatoid arthritis ( 21383967) Rheumatoid arthritis ( 20453842 19503088)
Protein-Protein Interactions		13 interactors: CBL CBLB FHL2 GAB2 MAP3K7 SRC TAB2 TNFSF11 TRAF1 TRAF2 TRAF3 TRAF5 TRAF6	164 interactors: A1CF ACTN3 AES AKAP17A ALS2CR11 AQP1 ARNT2 ARSJ BARD1 BCL6 BEX2 BIRC2 BIRC3 C14orf105 C19orf66 C1orf109 C1orf216 C5orf30 CARHSP1 CASP10 CASP3 CASP6 CASP8 CCDC116 CCDC120 CCDC146 CCHCR1 CD40 CDCA3 CDKN1A CDKN2B CFLAR CHCHD3 COX5B CRYGA CYB5R2 DEPTOR DGCR6 DMRT3 DOK3 ECH1 EDAR EHHADH EWSR1 FAM161A FAM86C1 FBF1 FBXL18 FOSL2 GATA2 GATAD2B GEM GFI1B GIT2 GLRX3 GMCL1P1 GNG5 GORASP2 HAUS1 HEY2 HIVEP3 HOXA1 HOXD12 IKBKB JOSD1 KIAA1217 KIF1A KLHL38 KPNA2 LATS1 LCOR LOC149950 LTBR MAP3K14 MAP6 MAPRE2 METTL17 MORN3 MOS MYEF2 NEBL NGFRAP1 NUFIP2 NUPL1 OLIG3 PBX3 PDE4D PHF21A PIN1 PKN1 PLEKHN1 POM121L4P POP5 PPP1R13B PRDM7 PSMA1 PSMB1 QRICH1 RASAL2 RASSF5 RBCK1 RBM41 RBM45 RIPK1 RIPK2 RNF31 RTP5 SCNM1 SIK3 SLC25A48 SLC25A6 SNW1 SPG21 SPOP SRC SSC5D STK3 SYCE1 TANK TBC1D16 TCL1A TEAD4 TFAP4 THAP7 TICAM1 TNFAIP3 TNFRSF11A TNFRSF12A TNFRSF14 TNFRSF17 TNFRSF18 TNFRSF19 TNFRSF1A TNFRSF1B TNFRSF4 TNFRSF8 TNFRSF9 TNFSF9 TRADD TRAF2 TRAF3IP2 TRAF6 TRAIP TRIM23 TRIM37 TRIM42 TRPV6 TSSC4 USP7 WAC ZC2HC1C ZFYVE21 ZFYVE26 ZNF124 ZNF20 ZNF417 ZNF440 ZNF502 ZNF512B ZNF564 ZNF572 ZNF581 ZNF587 ZNF662
Entrez ID		8792	7185
HPRD ID		04609	03418
Ensembl ID		ENSG00000141655	ENSG00000056558
Uniprot IDs		I4EC36 I4EC38 N0GVH0 Q59EP9 Q9Y6Q6	Q13077
PDB IDs		1LB5	3M0D
Enriched GO Terms of Interacting Partners?		Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Immune System Process TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Positive Regulation Of MAP Kinase Activity Immune Response-regulating Signaling Pathway Regulation Of Cell Activation Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Signal Transduction Toll-like Receptor Signaling Pathway Immune Response Regulation Of Immune System Process Activation Of Protein Kinase Activity Signal Transduction Positive Regulation Of Protein Serine/threonine Kinase Activity Regulation Of Signal Transduction Regulation Of MAP Kinase Activity Regulation Of T Cell Activation Positive Regulation Of Cell Activation Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Regulation Of Apoptotic Process Osteoclast Differentiation Signaling Activation Of Innate Immune Response Cell Communication Regulation Of Signaling Regulation Of Cell Death Positive Regulation Of Immune Response Regulation Of Cell-cell Adhesion I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Lymphocyte Activation Positive Regulation Of Innate Immune Response Intracellular Receptor Signaling Pathway Positive Regulation Of JUN Kinase Activity Positive Regulation Of T Cell Activation Positive Regulation Of MAPK Cascade Cellular Response To Stimulus Positive Regulation Of Homotypic Cell-cell Adhesion Innate Immune Response Positive Regulation Of Protein Kinase Activity Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of JUN Kinase Activity Positive Regulation Of Kinase Activity Positive Regulation Of T Cell Cytokine Production	Cell Death Death Programmed Cell Death Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Apoptotic Process Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of Cell Death Positive Regulation Of Protein Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Signal Transduction Regulation Of Nitrogen Compound Metabolic Process Regulation Of Cellular Protein Metabolic Process Positive Regulation Of NF-kappaB Transcription Factor Activity Response To Tumor Necrosis Factor Regulation Of Protein Metabolic Process Positive Regulation Of Programmed Cell Death Intracellular Signal Transduction Positive Regulation Of Cell Death Regulation Of Metabolic Process Positive Regulation Of Apoptotic Process Regulation Of Cellular Process TRIF-dependent Toll-like Receptor Signaling Pathway Regulation Of Sequence-specific DNA Binding Transcription Factor Activity MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Cellular Response To Tumor Necrosis Factor Regulation Of Necroptotic Process Regulation Of Transcription, DNA-templated Immune System Process Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of RNA Metabolic Process Regulation Of Nucleic Acid-templated Transcription Signal Transduction Regulation Of RNA Biosynthetic Process Toll-like Receptor 4 Signaling Pathway Regulation Of Gene Expression Regulation Of Intracellular Signal Transduction Regulation Of Signal Transduction Positive Regulation Of Cellular Metabolic Process Signaling Immune Response-regulating Signaling Pathway Regulation Of Cytokine Production Cell Communication Pattern Recognition Receptor Signaling Pathway Positive Regulation Of Immune System Process Innate Immune Response-activating Signal Transduction Positive Regulation Of Protein Modification Process
Tagcloud ?		allelic atg autophagy becn1 contexts cooperation delays fvb heterozygosity implicating mammary mmtv monoallelic multiparous nfkb nonautophagy palb2 paradoxical parity pymt questioned seemingly suppressive tnbcs tumorigenesis wingless wnt1	adaptor appear characterization convey daxx death domains effector fadd far growing homologies insights isolation jun mammalian members mort necrosis represents rip seem share signals superfamily tnfr tradd transmit
Tagcloud (Difference) ?		allelic atg autophagy becn1 contexts cooperation delays fvb heterozygosity implicating mammary mmtv monoallelic multiparous nfkb nonautophagy palb2 paradoxical parity pymt questioned seemingly suppressive tnbcs tumorigenesis wingless wnt1	adaptor appear characterization convey daxx death domains effector fadd far growing homologies insights isolation jun mammalian members mort necrosis represents rip seem share signals superfamily tnfr tradd transmit
Tagcloud (Intersection) ?