TNFRSF11A

Gene Name		tumor necrosis factor receptor superfamily, member 11a, NFKB activator
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Gene Ontology Annotations	Cellular Component	External Side Of Plasma Membrane Integral Component Of Membrane
	Molecular Function	Receptor Activity Transmembrane Signaling Receptor Activity Tumor Necrosis Factor-activated Receptor Activity Protein Binding Cytokine Binding Metal Ion Binding
	Biological Process	Ossification Adaptive Immune Response Monocyte Chemotaxis Signal Transduction Cell-cell Signaling Positive Regulation Of Cell Proliferation Response To Radiation Osteoclast Differentiation Response To Lipopolysaccharide Tumor Necrosis Factor-mediated Signaling Pathway Response To Cytokine Response To Tumor Necrosis Factor Positive Regulation Of JUN Kinase Activity Lymph Node Development Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Circadian Temperature Homeostasis Mammary Gland Alveolus Development Response To Interleukin-1 Positive Regulation Of Fever Generation By Positive Regulation Of Prostaglandin Secretion TNFSF11-mediated Signaling Pathway Positive Regulation Of ERK1 And ERK2 Cascade Via TNFSF11-mediated Signaling
Pathways
Drugs
Diseases
GWAS		Bone mineral density ( 22504420) Bone mineral density (spine) ( 19801982) Paget's disease ( 21623375 20436471) Response to antipsychotic treatment ( 23241943) Serum albumin level ( 23022100)
Protein-protein Interactions		13 interactors: CBL CBLB FHL2 GAB2 MAP3K7 SRC TAB2 TNFSF11 TRAF1 TRAF2 TRAF3 TRAF5 TRAF6
Entrez ID		8792
HPRD ID		04609
Ensembl ID		ENSG00000141655
Uniprot IDs		I4EC36 I4EC38 N0GVH0 Q59EP9 Q9Y6Q6
PDB IDs		1LB5
Enriched GO Terms of Interacting Partners?		Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Immune System Process TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Positive Regulation Of MAP Kinase Activity Immune Response-regulating Signaling Pathway Regulation Of Cell Activation Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Signal Transduction Toll-like Receptor Signaling Pathway Immune Response Regulation Of Immune System Process Activation Of Protein Kinase Activity Signal Transduction Positive Regulation Of Protein Serine/threonine Kinase Activity Regulation Of Signal Transduction Regulation Of MAP Kinase Activity Regulation Of T Cell Activation Positive Regulation Of Cell Activation Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Regulation Of Apoptotic Process Osteoclast Differentiation Signaling Activation Of Innate Immune Response Cell Communication Regulation Of Signaling Regulation Of Cell Death Positive Regulation Of Immune Response Regulation Of Cell-cell Adhesion I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Lymphocyte Activation Positive Regulation Of Innate Immune Response Intracellular Receptor Signaling Pathway Positive Regulation Of JUN Kinase Activity Positive Regulation Of T Cell Activation Positive Regulation Of MAPK Cascade Cellular Response To Stimulus Positive Regulation Of Homotypic Cell-cell Adhesion Innate Immune Response Positive Regulation Of Protein Kinase Activity Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of JUN Kinase Activity Positive Regulation Of Kinase Activity Positive Regulation Of T Cell Cytokine Production
Tagcloud ?		allelic atg autophagy becn1 contexts cooperation delays fvb heterozygosity implicating mammary mmtv monoallelic multiparous nfkb nonautophagy palb2 paradoxical parity pymt questioned seemingly suppressive tnbcs tumorigenesis wingless wnt1