TNFRSF11A and GAB2

Number of citations of the paper that reports this interaction (PubMedID 15750601)
0

Data Source:
HPRD (in vitro, in vivo)

		TNFRSF11A	GAB2
Description		TNF receptor superfamily member 11a	GRB2 associated binding protein 2
Image
GO Annotations	Cellular Component	Cytosol Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane Membrane Raft	Cytoplasm Cytosol Plasma Membrane Membrane Membrane Raft
	Molecular Function	Transmembrane Signaling Receptor Activity Tumor Necrosis Factor Receptor Activity Protein Binding Cytokine Binding Signaling Receptor Activity Metal Ion Binding	Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Protein Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Phosphatidylinositol-3,4-bisphosphate Binding
	Biological Process	Ossification Adaptive Immune Response Immune System Process Monocyte Chemotaxis Signal Transduction Cell-cell Signaling Positive Regulation Of Cell Population Proliferation Response To Mechanical Stimulus Osteoclast Differentiation Response To Lipopolysaccharide Response To Insulin Tumor Necrosis Factor-mediated Signaling Pathway Cellular Response To Zinc Ion Starvation Response To Tumor Necrosis Factor Positive Regulation Of Canonical NF-kappaB Signal Transduction Response To Ethanol Positive Regulation Of Osteoclast Differentiation Positive Regulation Of Bone Resorption Positive Regulation Of JNK Cascade Lymph Node Development Circadian Temperature Homeostasis Mammary Gland Alveolus Development Positive Regulation Of ERK1 And ERK2 Cascade Response To Interleukin-1 Positive Regulation Of Fever Generation By Positive Regulation Of Prostaglandin Secretion Multinuclear Osteoclast Differentiation Positive Regulation Of Non-canonical NF-kappaB Signal Transduction	Signal Transduction Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Cell Population Proliferation Osteoclast Differentiation Positive Regulation Of Mast Cell Degranulation Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Pathways		TNFR2 non-canonical NF-kB pathway TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway	PI3K Cascade PIP3 activates AKT signaling Signaling by SCF-KIT Signaling by cytosolic FGFR1 fusion mutants Constitutive Signaling by Aberrant PI3K in Cancer Role of LAT2/NTAL/LAB on calcium mobilization Role of LAT2/NTAL/LAB on calcium mobilization PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling RET signaling Interleukin-15 signaling Interleukin receptor SHC signaling FLT3 Signaling FLT3 Signaling STAT5 Activation Signaling by CSF3 (G-CSF) Signaling by CSF3 (G-CSF) Signaling by CSF1 (M-CSF) in myeloid cells STAT5 activation downstream of FLT3 ITD mutants Signaling by FLT3 fusion proteins Signaling by FLT3 fusion proteins Signaling by FLT3 ITD and TKD mutants Signaling by FLT3 ITD and TKD mutants
Drugs		ENMD-1198
Diseases		Osteopetrosis, including: Osteopetrosis, severe neonatal or infantile forms; Osteopetrosis, intermediate forms; Osteopetrosis with renal tubular acidosis; Osteopetrosis, late-onset form type 1; Osteopetrosis, late-onset form type 2; Osteopetrosis, osteoclast poor Paget's disease of bone and related disorders, including: ; Paget's disease of bone (PDB); Familial expansile osteolysis (FEO); Early-onset Paget's disease of bone (PDB2); Expansile skeletal hyperphosphatasia (ESH); Juvenile Paget's disease (JPD)
GWAS		Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Allergic disease (asthma, hay fever or eczema) ( 29083406) Asthma ( 32296059) Asthma (age of onset) ( 31036433) Asthma (childhood onset) ( 30929738 31036433) Asthma onset (childhood vs adult) ( 30929738) Blood protein levels ( 30072576) Bone mineral density (paediatric, skull) ( 24945404) Bone mineral density (spine) ( 19801982) Femoral neck bone mineral density ( 29499414) Heel bone mineral density ( 28869591 30598549) Lumbar spine bone mineral density ( 29499414 22504420) Myasthenia gravis ( 25643325) Paget's disease ( 20436471 21623375) Response to antipsychotic treatment ( 23241943) Serum albumin levels ( 23022100) Serum alkaline phosphatase levels ( 29403010 33339817 33547301) Vitiligo ( 27723757)	Alanine aminotransferase levels ( 33547301) Alzheimer's disease (late onset) ( 17553421) Alzheimer's disease (survival time) ( 25649651) Aspartate aminotransferase levels ( 33547301) Blond vs. brown/black hair color ( 30531825) Body mass index ( 28892062) Brown vs. black hair color ( 30531825) Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143) Creatine kinase levels ( 29403010) Creatinine levels ( 29403010) Diastolic blood pressure ( 30224653) Estimated glomerular filtration rate ( 31152163 30604766) Glomerular filtration rate ( 29403010) Hair color ( 29662168) High light scatter reticulocyte percentage of red cells ( 32888494) Intraocular pressure ( 29785010) Lactate dehydrogenase levels ( 29403010) LDL cholesterol ( 30275531) Lipid traits (pleiotropy) (HIPO component 2) ( 30289880) Menarche (age at onset) ( 25231870 21102462) Platelet distribution width ( 32888494) Testicular germ cell tumor ( 28604732 28604728 26503584) Total cholesterol levels ( 30275531) Tourette syndrome ( 30818990) Triglyceride levels ( 32203549) Triglycerides ( 30275531)
Interacting Genes		13 interacting genes: CBL CBLB FHL2 GAB2 MAP3K7 SRC TAB2 TNFSF11 TRAF1 TRAF2 TRAF3 TRAF5 TRAF6	30 interacting genes: AKT1 ARHGAP32 CD247 CRKL EPOR ETV6 GAB1 GRAP GRAP2 GRB2 INPP5D LAT LCK LYN MAPK1 MAPK3 MAPK4 MYO15B NCK1 PIK3R1 PLCG1 PLCG2 PTPN11 PTPN6 SHC1 SNCA SRC SYK TNFRSF11A ZAP70
Entrez ID		8792	9846
HPRD ID		04609	05866
Ensembl ID		ENSG00000141655	ENSG00000033327
Uniprot IDs		Q9Y6Q6	Q9UQC2
PDB IDs		1LB5	2VWF 2W0Z 5EWZ 5EXA 6Y3R 6Y3S 6ZVB 6ZVC 6ZVD 6ZVE
Enriched GO Terms of Interacting Partners?		Tumor Necrosis Factor Receptor Binding Cytokine-mediated Signaling Pathway Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of Canonical NF-kappaB Signal Transduction Thioesterase Binding CD40 Receptor Complex Signaling Adaptor Activity Non-canonical NF-kappaB Signal Transduction Cell Surface Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Positive Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Signal Transduction Positive Regulation Of Kinase Activity Positive Regulation Of Protein Kinase Activity CD40 Signaling Pathway Interleukin-17-mediated Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of JUN Kinase Activity Positive Regulation Of Protein Serine/threonine Kinase Activity Toll-like Receptor 3 Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Ubiquitin Protein Ligase Activity Regulation Of Apoptotic Process Regulation Of Cell Communication Regulation Of Signaling Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Protein Modification Process Regulation Of Programmed Cell Death Positive Regulation Of Immune System Process Positive Regulation Of NF-kappaB Transcription Factor Activity Membrane Raft Stimulatory C-type Lectin Receptor Signaling Pathway Cellular Response To Lectin Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Protein Phosphorylation Regulation Of Protein Kinase Activity Bone Resorption Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Endolysosomal Toll-like Receptor Signaling Pathway Ubiquitin-protein Transferase Activity Positive Regulation Of Phosphorylation Regulation Of Kinase Activity Cytoplasmic Side Of Plasma Membrane Positive Regulation Of T Cell Cytokine Production Positive Regulation Of DNA-binding Transcription Factor Activity Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Protein Serine/threonine Kinase Activity Ubiquitin Protein Ligase Binding	Phosphotyrosine Residue Binding Immune Response-activating Cell Surface Receptor Signaling Pathway Antigen Receptor-mediated Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-activating Signaling Pathway Immune Response-regulating Signaling Pathway Activation Of Immune Response Regulation Of MAPK Cascade Positive Regulation Of Immune System Process T Cell Receptor Signaling Pathway Intracellular Signal Transduction Regulation Of Immune Response Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Cell Surface Receptor Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Immune System Process Positive Regulation Of Immune Response ERBB Signaling Pathway Regulation Of Intracellular Signal Transduction Signal Transduction Enzyme-linked Receptor Protein Signaling Pathway Intracellular Signaling Cassette Leukocyte Activation Positive Regulation Of MAPK Cascade Regulation Of Signal Transduction Positive Regulation Of Intracellular Signal Transduction Regulation Of Cell Activation T Cell Costimulation Immune System Process Cell-cell Junction Regulation Of T Cell Activation Cell Activation Regulation Of Lymphocyte Activation Regulation Of Defense Response Peptidyl-tyrosine Phosphorylation B Cell Receptor Signaling Pathway Fc Receptor Signaling Pathway Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Lymphocyte Activation Regulation Of Signaling Regulation Of Cell Communication Positive Regulation Of T Cell Activation Insulin-like Growth Factor Receptor Signaling Pathway Regulation Of Leukocyte Cell-cell Adhesion Positive Regulation Of Leukocyte Cell-cell Adhesion Positive Regulation Of Cell Activation Negative Regulation Of Immune System Process Regulation Of Multicellular Organismal Process Cytokine-mediated Signaling Pathway
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?