TNFRSF11A and TAB2

Number of citations of the paper that reports this interaction (PubMedID 11809792)
46

Data Source:
HPRD (in vivo)

		TNFRSF11A	TAB2
Description		TNF receptor superfamily member 11a	TGF-beta activated kinase 1 (MAP3K7) binding protein 2
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GO Annotations	Cellular Component	Cytosol Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane Membrane Raft	Nucleoplasm Cytoplasm Lysosome Lysosomal Membrane Endosome Cytosol Plasma Membrane Endosome Membrane Membrane
	Molecular Function	Transmembrane Signaling Receptor Activity Tumor Necrosis Factor Receptor Activity Protein Binding Cytokine Binding Signaling Receptor Activity Metal Ion Binding	Protein Binding Zinc Ion Binding Ubiquitin Binding Metal Ion Binding Molecular Adaptor Activity K63-linked Polyubiquitin Modification-dependent Protein Binding
	Biological Process	Ossification Adaptive Immune Response Immune System Process Monocyte Chemotaxis Signal Transduction Cell-cell Signaling Positive Regulation Of Cell Population Proliferation Response To Mechanical Stimulus Osteoclast Differentiation Response To Lipopolysaccharide Response To Insulin Tumor Necrosis Factor-mediated Signaling Pathway Cellular Response To Zinc Ion Starvation Response To Tumor Necrosis Factor Positive Regulation Of Canonical NF-kappaB Signal Transduction Response To Ethanol Positive Regulation Of Osteoclast Differentiation Positive Regulation Of Bone Resorption Positive Regulation Of JNK Cascade Lymph Node Development Circadian Temperature Homeostasis Mammary Gland Alveolus Development Positive Regulation Of ERK1 And ERK2 Cascade Response To Interleukin-1 Positive Regulation Of Fever Generation By Positive Regulation Of Prostaglandin Secretion Multinuclear Osteoclast Differentiation Positive Regulation Of Non-canonical NF-kappaB Signal Transduction	Inflammatory Response Canonical NF-kappaB Signal Transduction Heart Development Response To Bacterium Negative Regulation Of Autophagy Response To Lipopolysaccharide Non-canonical NF-kappaB Signal Transduction P38MAPK Cascade Defense Response To Bacterium Positive Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Protein Kinase Activity Protein K63-linked Ubiquitination
Pathways		TNFR2 non-canonical NF-kB pathway TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway	Nuclear signaling by ERBB4 Nuclear signaling by ERBB4 NOD1/2 Signaling Pathway Downstream TCR signaling FCERI mediated NF-kB activation TAK1-dependent IKK and NF-kappa-B activation activated TAK1 mediates p38 MAPK activation JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 TNFR1-induced NF-kappa-B signaling pathway CLEC7A (Dectin-1) signaling TICAM1,TRAF6-dependent induction of TAK1 complex Interleukin-1 signaling IRAK2 mediated activation of TAK1 complex TRAF6-mediated induction of TAK1 complex within TLR4 complex Alpha-protein kinase 1 signaling pathway SARS-CoV-2 activates/modulates innate and adaptive immune responses IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
Drugs		ENMD-1198
Diseases		Osteopetrosis, including: Osteopetrosis, severe neonatal or infantile forms; Osteopetrosis, intermediate forms; Osteopetrosis with renal tubular acidosis; Osteopetrosis, late-onset form type 1; Osteopetrosis, late-onset form type 2; Osteopetrosis, osteoclast poor Paget's disease of bone and related disorders, including: ; Paget's disease of bone (PDB); Familial expansile osteolysis (FEO); Early-onset Paget's disease of bone (PDB2); Expansile skeletal hyperphosphatasia (ESH); Juvenile Paget's disease (JPD)
GWAS		Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Allergic disease (asthma, hay fever or eczema) ( 29083406) Asthma ( 32296059) Asthma (age of onset) ( 31036433) Asthma (childhood onset) ( 30929738 31036433) Asthma onset (childhood vs adult) ( 30929738) Blood protein levels ( 30072576) Bone mineral density (paediatric, skull) ( 24945404) Bone mineral density (spine) ( 19801982) Femoral neck bone mineral density ( 29499414) Heel bone mineral density ( 28869591 30598549) Lumbar spine bone mineral density ( 29499414 22504420) Myasthenia gravis ( 25643325) Paget's disease ( 20436471 21623375) Response to antipsychotic treatment ( 23241943) Serum albumin levels ( 23022100) Serum alkaline phosphatase levels ( 29403010 33339817 33547301) Vitiligo ( 27723757)	Breast cancer ( 22383897 29059683) Coronary artery disease ( 33020668) Diverticulitis ( 28585551) Dupuytren's disease ( 21732829 28886342) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172)
Interacting Genes		13 interacting genes: CBL CBLB FHL2 GAB2 MAP3K7 SRC TAB2 TNFSF11 TRAF1 TRAF2 TRAF3 TRAF5 TRAF6	44 interacting genes: APP CAMK2A CST9L EIF2AK2 EMILIN1 ERBB4 FN1 FOSL1 GTF2I HDAC1 HDAC3 HDAC5 HSF2BP IKBKB IKBKG IRAK1 KRT85 MAP3K7 NCOR1 NFKB1 NR2C2 NUMBL PPIL3 PPP2CB SLC19A3 TAB1 TBL1X TGM2 TNFRSF11A TPM3 TRAF2 TRAF3IP1 TRAF6 TRIM45 TTN UBC UBE2I VIM VPS52 XIAP YWHAZ ZBTB16 ZFP64 ZNF143
Entrez ID		8792	23118
HPRD ID		04609	05483
Ensembl ID		ENSG00000141655	ENSG00000055208
Uniprot IDs		Q9Y6Q6	B4DIR9 Q9NYJ8
PDB IDs		1LB5	2DAE 2WWZ 2WX0 2WX1 9AVT 9AVW
Enriched GO Terms of Interacting Partners?		Tumor Necrosis Factor Receptor Binding Cytokine-mediated Signaling Pathway Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of Canonical NF-kappaB Signal Transduction Thioesterase Binding CD40 Receptor Complex Signaling Adaptor Activity Non-canonical NF-kappaB Signal Transduction Cell Surface Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Positive Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Signal Transduction Positive Regulation Of Kinase Activity Positive Regulation Of Protein Kinase Activity CD40 Signaling Pathway Interleukin-17-mediated Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of JUN Kinase Activity Positive Regulation Of Protein Serine/threonine Kinase Activity Toll-like Receptor 3 Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Ubiquitin Protein Ligase Activity Regulation Of Apoptotic Process Regulation Of Cell Communication Regulation Of Signaling Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Protein Modification Process Regulation Of Programmed Cell Death Positive Regulation Of Immune System Process Positive Regulation Of NF-kappaB Transcription Factor Activity Membrane Raft Stimulatory C-type Lectin Receptor Signaling Pathway Cellular Response To Lectin Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Protein Phosphorylation Regulation Of Protein Kinase Activity Bone Resorption Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Endolysosomal Toll-like Receptor Signaling Pathway Ubiquitin-protein Transferase Activity Positive Regulation Of Phosphorylation Regulation Of Kinase Activity Cytoplasmic Side Of Plasma Membrane Positive Regulation Of T Cell Cytokine Production Positive Regulation Of DNA-binding Transcription Factor Activity Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Protein Serine/threonine Kinase Activity Ubiquitin Protein Ligase Binding	Canonical NF-kappaB Signal Transduction Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Signal Transduction Regulation Of MAPK Cascade Positive Regulation Of Intracellular Signal Transduction Negative Regulation Of Canonical NF-kappaB Signal Transduction Non-canonical NF-kappaB Signal Transduction Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Cell Communication Regulation Of Intracellular Signal Transduction Positive Regulation Of Signaling Regulation Of Gene Expression Regulation Of Signal Transduction Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Macromolecule Metabolic Process Regulation Of JNK Cascade Response To External Biotic Stimulus Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of Defense Response Positive Regulation Of Metabolic Process Defense Response Regulation Of Signaling Positive Regulation Of Defense Response Positive Regulation Of DNA-binding Transcription Factor Activity Regulation Of Cell Communication Identical Protein Binding Regulation Of Macromolecule Metabolic Process Protein Modification Process Positive Regulation Of Multicellular Organismal Process MyD88-dependent Toll-like Receptor Signaling Pathway Histone Deacetylase Complex Cytokine-mediated Signaling Pathway Regulation Of Cytokine Production Negative Regulation Of Macromolecule Biosynthetic Process Cytosol Toll-like Receptor Signaling Pathway Positive Regulation Of MAPK Cascade Negative Regulation Of Biosynthetic Process Pattern Recognition Receptor Signaling Pathway Cytoplasmic Pattern Recognition Receptor Signaling Pathway Immune Response-activating Signaling Pathway Negative Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Negative Regulation Of Intracellular Signal Transduction Regulation Of DNA-templated Transcription Innate Immune Response-activating Signaling Pathway Response To Other Organism
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