UBE2T and RNF128

Number of citations of the paper that reports this interaction (PMID 19549727)
40

Data Source:
BioGRID (two hybrid)

		UBE2T	RNF128
Gene Name		ubiquitin-conjugating enzyme E2T	ring finger protein 128, E3 ubiquitin protein ligase
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Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm	Late Endosome Endoplasmic Reticulum Golgi Apparatus Cytoskeleton Integral Component Of Membrane Perinuclear Region Of Cytoplasm
	Molecular Function	Chromatin Binding Ubiquitin-protein Transferase Activity ATP Binding Ligase Activity Ubiquitin-like Protein Transferase Activity Ubiquitin Protein Ligase Binding Ubiquitin Protein Ligase Activity Ubiquitin Conjugating Enzyme Activity	Ubiquitin-protein Transferase Activity Zinc Ion Binding Ligase Activity
	Biological Process	DNA Repair Protein Monoubiquitination Cellular Response To DNA Damage Stimulus Protein K29-linked Ubiquitination Protein K27-linked Ubiquitination Protein Autoubiquitination Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination Protein K6-linked Ubiquitination	Protein Ubiquitination Negative Regulation Of Cytokine Biosynthetic Process
Pathways		Fanconi Anemia pathway
Drugs
Diseases
GWAS		Breast cancer ( 23535733)
Protein-Protein Interactions		14 interactors: AMFR ARIH2 BRCA1 FANCL LNX2 MARCH5 MGRN1 PCGF2 RNF128 RNF144B RNF4 TRIM27 UBA1 UBA6	13 interactors: APPBP2 CD151 CD40LG CD81 CEP76 OTUB1 TP53 UBE2D1 UBE2E1 UBE2H UBE2I UBE2N UBE2T
Entrez ID		29089	79589
HPRD ID		13704	02340
Ensembl ID		ENSG00000077152	ENSG00000133135
Uniprot IDs		Q9NPD8	Q8TEB7
PDB IDs		1YH2	3ICU
Enriched GO Terms of Interacting Partners?		Protein Ubiquitination Protein Modification By Small Protein Conjugation Protein Polyubiquitination Cellular Protein Modification Process Cellular Protein Metabolic Process Protein Metabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Catabolic Process Protein K63-linked Ubiquitination Protein Autoubiquitination Cellular Macromolecule Catabolic Process Ubiquitin-dependent Protein Catabolic Process Protein K6-linked Ubiquitination Proteolysis Cellular Metabolic Process Protein K48-linked Ubiquitination Androgen Receptor Signaling Pathway Protein Monoubiquitination Catabolic Process Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Histone H4-K20 Methylation Positive Regulation Of Histone H4-K16 Acetylation Intracellular Steroid Hormone Receptor Signaling Pathway Cellular Response To Stress Regulation Of Kinetochore Assembly Negative Regulation Of Interleukin-2 Secretion Positive Regulation Of Histone H3-K9 Acetylation Positive Regulation Of Organelle Organization Regulation Of Organelle Organization Positive Regulation Of Histone H4 Acetylation Negative Regulation Of Histone H3-K4 Methylation Regulation Of Centromere Complex Assembly Protein Oligomerization Regulation Of Cytoskeleton Organization Cellular Response To Indole-3-methanol Regulation Of Microtubule Cytoskeleton Organization Negative Regulation Of Centriole Replication Negative Regulation Of Calcium Ion Import Regulation Of Cytokine Production Dosage Compensation By Inactivation Of X Chromosome Regulation Of Microtubule-based Process Negative Regulation Of CAMP-mediated Signaling Interferon-gamma Secretion Negative Regulation Of Histone H3-K9 Methylation Positive Regulation Of Histone H3-K9 Methylation Dosage Compensation Regulation Of Histone H3-K9 Acetylation Metabolic Process	Protein K48-linked Ubiquitination Protein Polyubiquitination Regulation Of Chromosome Organization Protein Ubiquitination Protein Modification By Small Protein Conjugation Regulation Of Histone Ubiquitination Regulation Of Protein Ubiquitination Regulation Of Organelle Organization Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Transferase Activity Cellular Protein Catabolic Process Positive Regulation Of Ligase Activity Protein Catabolic Process Regulation Of Ubiquitin-protein Transferase Activity Negative Regulation Of Chromosome Organization Mitotic Cell Cycle Process Negative Regulation Of Protein Ubiquitination Lymphocyte Proliferation Mononuclear Cell Proliferation Mitotic Cell Cycle Leukocyte Proliferation Regulation Of Histone Modification Positive Regulation Of Protein Ubiquitination Cellular Macromolecule Catabolic Process Negative Regulation Of Mitotic Cell Cycle Phase Transition Protein K11-linked Ubiquitination Positive Regulation Of Protein Modification Process Proteolysis Mitotic Cell Cycle Checkpoint Regulation Of Cell Cycle Process Cell Cycle Process Protein K63-linked Ubiquitination Mitotic Spindle Assembly Checkpoint DNA Metabolic Process Histone Ubiquitination Spindle Assembly Checkpoint Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Mitotic Cell Cycle Mitotic Spindle Checkpoint DNA Repair Regulation Of Cell Cycle Phase Transition Cell Cycle Checkpoint Protein Monoubiquitination Negative Regulation Of Chromosome Segregation Regulation Of Cellular Component Organization Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
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