UBE2T and AMFR

Number of citations of the paper that reports this interaction (PubMedID 19690564)
61

Data Source:
BioGRID (two hybrid)

		UBE2T	AMFR
Description		ubiquitin conjugating enzyme E2 T	autocrine motility factor receptor
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus	Ubiquitin Ligase Complex Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Membrane Dendrite Growth Cone Protein-containing Complex Derlin-1 Retrotranslocation Complex Neuronal Cell Body Endoplasmic Reticulum Quality Control Compartment Perinuclear Region Of Cytoplasm
	Molecular Function	Nucleotide Binding Chromatin Binding Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Transferase Activity Ubiquitin-like Protein Transferase Activity Ubiquitin Protein Ligase Binding Ubiquitin Conjugating Enzyme Activity	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Protein-macromolecule Adaptor Activity Ubiquitin-ubiquitin Ligase Activity Signaling Receptor Activity Identical Protein Binding Ubiquitin Binding Metal Ion Binding Protein-folding Chaperone Binding Ubiquitin Protein Ligase Activity BAT3 Complex Binding Ubiquitin-specific Protease Binding
	Biological Process	Protein Polyubiquitination DNA Repair Protein Monoubiquitination DNA Damage Response Protein Ubiquitination Protein Modification By Small Protein Conjugation Protein K29-linked Ubiquitination Protein K27-linked Ubiquitination Protein Autoubiquitination Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination Protein K6-linked Ubiquitination	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Signal Transduction Canonical NF-kappaB Signal Transduction Learning Or Memory Wnt Signaling Pathway Protein Ubiquitination Endoplasmic Reticulum Unfolded Protein Response ERAD Pathway Non-canonical NF-kappaB Signal Transduction Protein K27-linked Ubiquitination Protein Autoubiquitination Protein K48-linked Ubiquitination Negative Regulation Of Canonical Wnt Signaling Pathway Endoplasmic Reticulum Mannose Trimming Regulation Of SREBP Signaling Pathway
Pathways		Fanconi Anemia Pathway Synthesis of active ubiquitin: roles of E1 and E2 enzymes	N-glycan trimming in the ER and Calnexin/Calreticulin cycle ER Quality Control Compartment (ERQC)
Drugs
Diseases
GWAS		Breast cancer ( 23535733) Celiac disease ( 23936387)	Apolipoprotein A1 levels ( 32203549) Breast cancer ( 29059683)
Interacting Genes		25 interacting genes: AMFR ARIH2 BRCA1 CDK2 CHEK1 FANCD2 FANCL LNX2 MARCHF5 MGRN1 PCGF2 PRKCG PRKN RNF128 RNF144B RNF167 RNF31 RNF4 ROCK1 RPS6KA1 TRIM27 UBA1 UBA6 UBC ZNRF2	32 interacting genes: BAG6 CRMP1 CYP2E1 DERL1 DHFR GPI HERPUD1 HTT KPNB1 MGRN1 PPP1R13L RETREG1 SOD1 TAB3 TMCO1 TOM1L1 TRIM25 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2G1 UBE2G2 UBE2K UBE2N UBE2T UBE2W UBL4A UFD1 USP13 VCP
Entrez ID		29089	267
HPRD ID		13704	09130
Ensembl ID		ENSG00000077152	ENSG00000159461
Uniprot IDs		Q9NPD8	Q9UKV5
PDB IDs		1YH2 4CCG 5NGZ 5OJJ 6R75 7KZR 7KZS 7KZT 7KZV 8JUC 8JVD 8JVE 8JVL	2EJS 2LVN 2LVO 2LVP 2LVQ 2LXH 2LXP 3FSH 3H8K 3TIW 4G3O 4LAD 8T0S
Enriched GO Terms of Interacting Partners?		Protein Ubiquitination Post-translational Protein Modification Protein Modification By Small Protein Conjugation Protein Modification Process Ubiquitin Protein Ligase Activity Ubiquitin-protein Transferase Activity Transferase Activity Protein Polyubiquitination Protein Metabolic Process Zinc Ion Binding Metal Ion Binding Modification-dependent Protein Catabolic Process Macromolecule Metabolic Process Proteolysis Involved In Protein Catabolic Process Protein K63-linked Ubiquitination Ubiquitin-dependent Protein Catabolic Process Protein K48-linked Ubiquitination Ubiquitin Ligase Complex Protein Autoubiquitination Protein K6-linked Ubiquitination Macromolecule Catabolic Process Proteolysis Response To Stress Cellular Response To Stress Protein K27-linked Ubiquitination Mitotic DNA Damage Checkpoint Signaling Mitotic DNA Integrity Checkpoint Signaling Cytosol Ubiquitin Activating Enzyme Activity DNA Damage Response DNA Damage Checkpoint Signaling Ubiquitin Conjugating Enzyme Binding Condensed Chromosome Negative Regulation Of Programmed Cell Death Regulation Of Organelle Organization Catabolic Process Regulation Of Protein Targeting To Mitochondrion Ubiquitin Protein Ligase Binding Signal Transduction In Response To DNA Damage Protein Monoubiquitination Cytoplasm Ubiquitin-like Modifier Activating Enzyme Activity Negative Regulation Of Signal Transduction Intracellular Signal Transduction Positive Regulation Of Autophagy Negative Regulation Of Cell Cycle Protein Serine Kinase Activity Protein K29-linked Ubiquitination Negative Regulation Of Cell Communication Negative Regulation Of Signaling	Ubiquitin Conjugating Enzyme Activity Modification-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Macromolecule Catabolic Process Catabolic Process Ubiquitin-protein Transferase Activity Proteolysis Protein Polyubiquitination Protein K48-linked Ubiquitination Protein Ubiquitination Ubiquitin Protein Ligase Binding Post-translational Protein Modification Protein Modification By Small Protein Conjugation Proteasomal Protein Catabolic Process ERAD Pathway Protein Monoubiquitination Protein Catabolic Process Protein Modification Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Cellular Response To Misfolded Protein Protein Metabolic Process Response To Misfolded Protein Response To Endoplasmic Reticulum Stress Retrograde Protein Transport, ER To Cytosol Cytosol Cellular Response To Stress Cellular Response To Topologically Incorrect Protein Macromolecule Metabolic Process Protein Exit From Endoplasmic Reticulum Protein K11-linked Ubiquitination Regulation Of Proteasomal Protein Catabolic Process Endoplasmic Reticulum Stress-induced Pre-emptive Quality Control Positive Regulation Of ERAD Pathway Ubiquitin-like Protein Transferase Activity Ubiquitin-specific Protease Binding ATP Binding Negative Regulation Of Signal Transduction BAT3 Complex Transferase Activity Protein K63-linked Ubiquitination Regulation Of ERAD Pathway Negative Regulation Of Cell Communication Negative Regulation Of Signaling Protein K6-linked Ubiquitination Regulation Of Protein Metabolic Process Positive Regulation Of Protein Metabolic Process BAT3 Complex Binding Maintenance Of Unfolded Protein Regulation Of Ubiquitin-dependent Protein Catabolic Process
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