F2RL2 and ECT2

Number of citations of the paper that reports this interaction (PubMedID 15254234)
43

Data Source:
HPRD (two hybrid, in vitro)

		F2RL2	ECT2
Description		coagulation factor II thrombin receptor like 2	epithelial cell transforming 2
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Plasma Membrane Membrane Apical Plasma Membrane Protein-containing Complex	Nucleus Nucleoplasm Cytoplasm Centrosome Spindle Cytosol Cytoskeleton Cell-cell Junction Bicellular Tight Junction Cell Cortex Nuclear Body Midbody Cleavage Furrow Anchoring Junction Mitotic Spindle Centralspindlin Complex
	Molecular Function	Proteinase-activated Receptor Activity Phosphatidylinositol-4,5-bisphosphate Phospholipase C Activity G Protein-coupled Receptor Activity Protein Binding Thrombin-activated Receptor Activity Receptor Ligand Activity	Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding Small GTPase Binding Protein Homodimerization Activity
	Biological Process	Signal Transduction G Protein-coupled Receptor Signaling Pathway Blood Coagulation Hemostasis Response To Wounding Platelet Activation Positive Regulation Of Insulin Secretion Regulation Of Biological Quality Thrombin-activated Receptor Signaling Pathway Ligand-gated Ion Channel Signaling Pathway	Mitotic Cytokinesis Cell Morphogenesis Nervous System Development Protein Transport Cell Differentiation Activation Of Protein Kinase Activity Positive Regulation Of Cytokinesis Intracellular Signal Transduction Positive Regulation Of Protein Import Into Nucleus Positive Regulation Of Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of GTPase Activity Positive Regulation Of Neuron Differentiation Regulation Of Protein Kinase Activity Regulation Of Small GTPase Mediated Signal Transduction Protein Homooligomerization Cell Division Regulation Of Attachment Of Spindle Microtubules To Kinetochore Cellular Response To Hydrogen Peroxide Bicellular Tight Junction Assembly Cellular Response To Calcium Ion Cellular Response To Ionizing Radiation Activation Of GTPase Activity Positive Regulation Of Mitotic Cytokinetic Process Regulation Of Cytokinesis, Actomyosin Contractile Ring Assembly
Pathways		Peptide ligand-binding receptors G alpha (q) signalling events Thrombin signalling through proteinase activated receptors (PARs) Thrombin signalling through proteinase activated receptors (PARs)	NRAGE signals death through JNK G alpha (12/13) signalling events RHOA GTPase cycle RHOB GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle
Drugs
Diseases
GWAS		Mean platelet volume ( 28031487) Phenylephrine infusion rate during anesthesia ( 31455332)	Obesity-related traits ( 23251661) Red cell distribution width ( 32888494)
Interacting Genes		8 interacting genes: CDH5 CTSG ECT2 F11R F2 F2RL3 JAM2 JAM3	39 interacting genes: ABR C2orf42 CCDC91 CD19 CDK1 CHST10 CSTB EIF4A2 EIF5B ELOC ERAL1 F2RL2 FANCM GGN HACL2 KLHL20 LAMTOR5 MBD1 MT-CO2 MT2A NOMO1 NPC2 OOSP2 OTUB1 PARD6A PCOLCE PLK1 POMP PSMA6 RACGAP1 RHOG RPS20 SNRNP200 SPATA22 SRPK2 THAP11 UBB USP7 VDAC2
Entrez ID		2151	1894
HPRD ID		03561	11860
Ensembl ID		ENSG00000164220	ENSG00000114346
Uniprot IDs		O00254	Q9H8V3
PDB IDs			3L46 4N40 6L30
Enriched GO Terms of Interacting Partners?		Maintenance Of Blood-brain Barrier Bicellular Tight Junction Cell-cell Junction Anchoring Junction Tight Junction Cell-cell Adhesion Anatomical Structure Homeostasis Tissue Homeostasis Regulation Of Platelet Activation Hematopoietic Stem Cell Migration To Bone Marrow Protein Complex Involved In Cell Adhesion Positive Regulation Of Establishment Of Endothelial Barrier Protein Localization To Bicellular Tight Junction Leukocyte Migration Platelet Activation Hematopoietic Stem Cell Migration Protein Localization To Cell Junction Neutrophil-mediated Killing Of Bacterium Thrombin-activated Receptor Signaling Pathway Positive Regulation Of Platelet Aggregation Cell-cell Junction Assembly Cell Adhesion Regulation Of Establishment Of Endothelial Barrier Cellular Extravasation Protein Localization To Cell-cell Junction Cell Migration Positive Regulation Of Homotypic Cell-cell Adhesion Integrin Binding Neutrophil Mediated Immunity Multicellular Organismal-level Homeostasis Cell-cell Contact Zone Cell-cell Junction Organization Cell Motility Regulation Of Cytoskeleton Organization Regulation Of Platelet Aggregation Killing By Host Of Symbiont Cells Cell-cell Adhesion Mediator Activity Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Biological Process Involved In Interaction With Symbiont Regulation Of Endothelial Cell Differentiation Homeostatic Process Bicellular Tight Junction Assembly Cell Junction Assembly Tight Junction Assembly Adherens Junction Organization Tight Junction Organization Leukocyte Cell-cell Adhesion Positive Regulation Of Calcium Ion Transmembrane Transport Biofilm Matrix Disassembly Regulation Of Cytokinesis, Actomyosin Contractile Ring Assembly	Cytosol Positive Regulation Of Protein Monoubiquitination Regulation Of Protein Monoubiquitination
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