F2RL2 and F2RL3

Number of citations of the paper that reports this interaction (PubMedID 10766244)
0

Data Source:
HPRD (in vivo)

		F2RL2	F2RL3
Description		coagulation factor II thrombin receptor like 2	F2R like thrombin or trypsin receptor 3
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Plasma Membrane Membrane Apical Plasma Membrane Protein-containing Complex	Extracellular Region Plasma Membrane Membrane
	Molecular Function	Proteinase-activated Receptor Activity Phosphatidylinositol-4,5-bisphosphate Phospholipase C Activity G Protein-coupled Receptor Activity Protein Binding Thrombin-activated Receptor Activity Receptor Ligand Activity	Protease Binding G Protein-coupled Receptor Activity Thrombin-activated Receptor Activity
	Biological Process	Signal Transduction G Protein-coupled Receptor Signaling Pathway Blood Coagulation Hemostasis Response To Wounding Platelet Activation Positive Regulation Of Insulin Secretion Regulation Of Biological Quality Thrombin-activated Receptor Signaling Pathway Ligand-gated Ion Channel Signaling Pathway	Signal Transduction G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Blood Coagulation Hemostasis Response To Wounding Platelet Activation Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Platelet Dense Granule Organization Thrombin-activated Receptor Signaling Pathway Platelet Aggregation
Pathways		Peptide ligand-binding receptors G alpha (q) signalling events Thrombin signalling through proteinase activated receptors (PARs) Thrombin signalling through proteinase activated receptors (PARs)	Peptide ligand-binding receptors G alpha (q) signalling events Thrombin signalling through proteinase activated receptors (PARs) Thrombin signalling through proteinase activated receptors (PARs)
Drugs			Thrombin
Diseases
GWAS		Mean platelet volume ( 28031487) Phenylephrine infusion rate during anesthesia ( 31455332)	Metabolite levels ( 23823483)
Interacting Genes		8 interacting genes: CDH5 CTSG ECT2 F11R F2 F2RL3 JAM2 JAM3	2 interacting genes: F2 F2RL2
Entrez ID		2151	9002
HPRD ID		03561	04148
Ensembl ID		ENSG00000164220	ENSG00000127533
Uniprot IDs		O00254	Q96RI0
PDB IDs			2ZPK 3QDZ
Enriched GO Terms of Interacting Partners?		Maintenance Of Blood-brain Barrier Bicellular Tight Junction Cell-cell Junction Anchoring Junction Tight Junction Cell-cell Adhesion Anatomical Structure Homeostasis Tissue Homeostasis Regulation Of Platelet Activation Hematopoietic Stem Cell Migration To Bone Marrow Protein Complex Involved In Cell Adhesion Positive Regulation Of Establishment Of Endothelial Barrier Protein Localization To Bicellular Tight Junction Leukocyte Migration Platelet Activation Hematopoietic Stem Cell Migration Protein Localization To Cell Junction Neutrophil-mediated Killing Of Bacterium Thrombin-activated Receptor Signaling Pathway Positive Regulation Of Platelet Aggregation Cell-cell Junction Assembly Cell Adhesion Regulation Of Establishment Of Endothelial Barrier Cellular Extravasation Protein Localization To Cell-cell Junction Cell Migration Positive Regulation Of Homotypic Cell-cell Adhesion Integrin Binding Neutrophil Mediated Immunity Multicellular Organismal-level Homeostasis Cell-cell Contact Zone Cell-cell Junction Organization Cell Motility Regulation Of Cytoskeleton Organization Regulation Of Platelet Aggregation Killing By Host Of Symbiont Cells Cell-cell Adhesion Mediator Activity Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Biological Process Involved In Interaction With Symbiont Regulation Of Endothelial Cell Differentiation Homeostatic Process Bicellular Tight Junction Assembly Cell Junction Assembly Tight Junction Assembly Adherens Junction Organization Tight Junction Organization Leukocyte Cell-cell Adhesion Positive Regulation Of Calcium Ion Transmembrane Transport Biofilm Matrix Disassembly Regulation Of Cytokinesis, Actomyosin Contractile Ring Assembly	Thrombin-activated Receptor Signaling Pathway Ligand-gated Ion Channel Signaling Pathway Positive Regulation Of Peptide Hormone Secretion Platelet Activation Positive Regulation Of Peptide Secretion Positive Regulation Of Insulin Secretion Coagulation Blood Coagulation Hemostasis Receptor Ligand Activity Positive Regulation Of Protein Secretion Positive Regulation Of Hormone Secretion Regulation Of Insulin Secretion Regulation Of Peptide Hormone Secretion Response To Wounding Regulation Of Hormone Secretion Regulation Of Protein Secretion Positive Regulation Of Protein Transport Proteinase-activated Receptor Activity Regulation Of Body Fluid Levels Positive Regulation Of Secretion By Cell Positive Regulation Of Secretion Positive Regulation Of Establishment Of Protein Localization Thrombospondin Receptor Activity Neutrophil-mediated Killing Of Gram-negative Bacterium Thrombin-activated Receptor Activity Positive Regulation Of Protein Localization Regulation Of Protein Transport Positive Regulation Of Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Regulation Of Establishment Of Protein Localization Regulation Of Hormone Levels Regulation Of Secretion By Cell Neutrophil-mediated Killing Of Bacterium Cytolysis By Host Of Symbiont Cells Regulation Of Secretion Negative Regulation Of Fibrinolysis Cell Activation Negative Regulation Of Astrocyte Differentiation Regulation Of Fibrinolysis G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Platelet Activation Fibrinolysis Positive Regulation Of Transport Neutrophil Mediated Immunity Regulation Of Protein Localization Positive Regulation Of Collagen Biosynthetic Process Phosphatidylinositol-4,5-bisphosphate Phospholipase C Activity Negative Regulation Of Glial Cell Differentiation Positive Regulation Of Blood Coagulation Positive Regulation Of Coagulation
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