F2RL2 and JAM3

Number of citations of the paper that reports this interaction (PMID 12953056)
42

Data Source:
HPRD (in vitro, in vivo)

		F2RL2	JAM3
Gene Name		coagulation factor II (thrombin) receptor-like 2	junctional adhesion molecule 3
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Plasma Membrane Integral Component Of Plasma Membrane Apical Plasma Membrane	Extracellular Space Golgi Apparatus Plasma Membrane Tight Junction Integral Component Of Membrane Desmosome Paranodal Junction Schmidt-Lanterman Incisure Cell-cell Contact Zone
	Molecular Function	Phosphatidylinositol Phospholipase C Activity Protein Binding Thrombin Receptor Activity	Integrin Binding Protein Binding Protein Homodimerization Activity Protein Heterodimerization Activity
	Biological Process	Blood Coagulation Metabolic Process Response To Wounding Platelet Activation Thrombin Receptor Signaling Pathway	Angiogenesis Neutrophil Homeostasis Adaptive Immune Response Myeloid Progenitor Cell Differentiation Leukocyte Migration Involved In Inflammatory Response Cell-matrix Adhesion Spermatid Development Blood Coagulation Transmission Of Nerve Impulse Establishment Of Cell Polarity Extracellular Matrix Organization Axon Regeneration Myelination Leukocyte Migration Regulation Of Neutrophil Chemotaxis Regulation Of Actin Cytoskeleton Organization By Cell-cell Adhesion
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) G alpha (q) signalling events Signaling by GPCR Class A/1 (Rhodopsin-like receptors) Metabolic disorders of biological oxidation enzymes GPCR ligand binding G alpha (q) signalling events Thrombin signalling through proteinase activated receptors (PARs) GPCR downstream signaling Peptide ligand-binding receptors Gastrin-CREB signalling pathway via PKC and MAPK Platelet activation, signaling and aggregation	Integrin cell surface interactions Cell surface interactions at the vascular wall
Drugs
Diseases
GWAS
Protein-Protein Interactions		8 interactors: CDH5 CTSG ECT2 F11R F2 F2RL3 JAM2 JAM3	6 interactors: F2RL2 ITGAM ITGAX JAM2 PICK1 TJP1
Entrez ID		2151	83700
HPRD ID		03561	06042
Ensembl ID		ENSG00000164220	ENSG00000166086
Uniprot IDs		O00254	Q9BX67
PDB IDs
Enriched GO Terms of Interacting Partners?		Blood Coagulation Hemostasis Regulation Of Body Fluid Levels Wound Healing Leukocyte Migration Response To Wounding Extracellular Matrix Organization Extracellular Structure Organization Response To Stress Cell Junction Assembly Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Cell-cell Junction Organization Positive Regulation Of Intracellular Transport Positive Regulation Of Calcium Ion Transport Into Cytosol Cell Migration Tight Junction Assembly Cell Motility Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Response To Stimulus Apical Junction Assembly Immune System Process Inflammatory Response Regulation Of Calcium Ion Transport Into Cytosol Regulation Of Intracellular Transport Regulation Of Actin Cytoskeleton Organization By Cell-cell Adhesion Positive Regulation Of Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Cell Adhesion Positive Regulation Of Calcium Ion Transport Locomotion Regulation Of Cytoskeleton Organization Defense Response Neutrophil Mediated Killing Of Gram-positive Bacterium Cell-cell Junction Assembly Movement Of Cell Or Subcellular Component Regulation Of Ion Homeostasis Positive Regulation Of Transport Regulation Of Blood Pressure Cell Surface Receptor Signaling Pathway Regulation Of Calcium Ion Transport Platelet Activation Positive Regulation Of Ion Transport Establishment Of Endothelial Intestinal Barrier Regulation Of Cellular Component Organization Killing By Host Of Symbiont Cells Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Organelle Organization Myeloid Progenitor Cell Differentiation Signaling Platelet Dense Granule Organization Blood Vessel Maturation	Blood Coagulation Hemostasis Regulation Of Body Fluid Levels Wound Healing Response To Wounding Leukocyte Migration Extracellular Matrix Organization Extracellular Structure Organization Single Organismal Cell-cell Adhesion Cell-cell Signaling Involved In Cell-cell Junction Organization Glial Cell Development Response To Stress Integrin-mediated Signaling Pathway Response To External Stimulus Microglia Development Cell Migration Glial Cell Differentiation Response To Magnetism Cell Motility Ectodermal Cell Differentiation Gliogenesis Establishment Of Endothelial Intestinal Barrier Response To Stimulus DNA Methylation Involved In Embryo Development Cell Adhesion Dendritic Spine Maintenance Signal Transduction Locomotion Neuronal Ion Channel Clustering Thrombin Receptor Signaling Pathway Negative Regulation Of Arp2/3 Complex-mediated Actin Nucleation Negative Regulation Of Vascular Permeability Negative Regulation Of Actin Nucleation Cell Surface Receptor Signaling Pathway Signaling Cell Communication Movement Of Cell Or Subcellular Component Long Term Synaptic Depression Leukocyte Migration Involved In Inflammatory Response Positive Regulation Of Receptor Internalization Macrophage Differentiation Regulation Of Arp2/3 Complex-mediated Actin Nucleation Dendritic Spine Organization Heterotypic Cell-cell Adhesion DNA Methylation Involved In Gamete Generation Regulation Of Actin Nucleation Ectoderm Development Cellular Response To Glucose Starvation Monoamine Transport Cellular Component Maintenance
Tagcloud ?		al7a1 arhgap1 c25h16orf71 conceptus ddx58 degs endometria ensbtat00000050193 estrus fbxl7 herc6 ifi16 ifnt insemination lims2 loc507810 mgc127874 mgc128929 parp12 rnaseq rnf213 samd9 serbp1 srgap2 tbc1d1 wbscr17 znfx1 zswim4 zxfx1
Tagcloud (Difference) ?		al7a1 arhgap1 c25h16orf71 conceptus ddx58 degs endometria ensbtat00000050193 estrus fbxl7 herc6 ifi16 ifnt insemination lims2 loc507810 mgc127874 mgc128929 parp12 rnaseq rnf213 samd9 serbp1 srgap2 tbc1d1 wbscr17 znfx1 zswim4 zxfx1
Tagcloud (Intersection) ?