F2RL2 and CDH5

Number of citations of the paper that reports this interaction (PMID 17057644)
27

Data Source:
HPRD (in vivo, in vitro)

		F2RL2	CDH5
Gene Name		coagulation factor II (thrombin) receptor-like 2	cadherin 5, type 2 (vascular endothelium)
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Plasma Membrane Integral Component Of Plasma Membrane Apical Plasma Membrane	Plasma Membrane Cell-cell Junction Adherens Junction Tight Junction Membrane Integral Component Of Membrane Cell Junction
	Molecular Function	Phosphatidylinositol Phospholipase C Activity Protein Binding Thrombin Receptor Activity	Receptor Binding Calcium Ion Binding Protein Binding Beta-catenin Binding Protein Phosphatase Binding Ion Channel Binding
	Biological Process	Blood Coagulation Metabolic Process Response To Wounding Platelet Activation Thrombin Receptor Signaling Pathway	Blood Vessel Maturation Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Negative Regulation Of Cell Proliferation Cell Junction Assembly Adherens Junction Organization Cell-cell Junction Organization Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Establishment Of Cell Polarity
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) G alpha (q) signalling events Signaling by GPCR Class A/1 (Rhodopsin-like receptors) Metabolic disorders of biological oxidation enzymes GPCR ligand binding G alpha (q) signalling events Thrombin signalling through proteinase activated receptors (PARs) GPCR downstream signaling Peptide ligand-binding receptors Gastrin-CREB signalling pathway via PKC and MAPK Platelet activation, signaling and aggregation	Cell junction organization Cell-cell junction organization Signaling by VEGF Adherens junctions interactions VEGFR2 mediated vascular permeability VEGFA-VEGFR2 Pathway
Drugs
Diseases
GWAS
Protein-Protein Interactions		8 interactors: CDH5 CTSG ECT2 F11R F2 F2RL3 JAM2 JAM3	20 interactors: CSK CTNNA1 CTNNB1 CTNND1 DSP EPHA2 F2RL2 FGA JUP KDR P2RX4 P2RX6 PARD6A PKP4 PTPN11 PTPRB SHC1 SMG1 SRC VIM
Entrez ID		2151	1003
HPRD ID		03561	03075
Ensembl ID		ENSG00000164220	ENSG00000179776
Uniprot IDs		O00254	P33151
PDB IDs
Enriched GO Terms of Interacting Partners?		Blood Coagulation Hemostasis Regulation Of Body Fluid Levels Wound Healing Leukocyte Migration Response To Wounding Extracellular Matrix Organization Extracellular Structure Organization Response To Stress Cell Junction Assembly Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Cell-cell Junction Organization Positive Regulation Of Intracellular Transport Positive Regulation Of Calcium Ion Transport Into Cytosol Cell Migration Tight Junction Assembly Cell Motility Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Response To Stimulus Apical Junction Assembly Immune System Process Inflammatory Response Regulation Of Calcium Ion Transport Into Cytosol Regulation Of Intracellular Transport Regulation Of Actin Cytoskeleton Organization By Cell-cell Adhesion Positive Regulation Of Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Cell Adhesion Positive Regulation Of Calcium Ion Transport Locomotion Regulation Of Cytoskeleton Organization Defense Response Neutrophil Mediated Killing Of Gram-positive Bacterium Cell-cell Junction Assembly Movement Of Cell Or Subcellular Component Regulation Of Ion Homeostasis Positive Regulation Of Transport Regulation Of Blood Pressure Cell Surface Receptor Signaling Pathway Regulation Of Calcium Ion Transport Platelet Activation Positive Regulation Of Ion Transport Establishment Of Endothelial Intestinal Barrier Regulation Of Cellular Component Organization Killing By Host Of Symbiont Cells Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Organelle Organization Myeloid Progenitor Cell Differentiation Signaling Platelet Dense Granule Organization Blood Vessel Maturation	Cell-cell Junction Organization Adherens Junction Organization Signaling Enzyme Linked Receptor Protein Signaling Pathway Cell Communication Single Organismal Cell-cell Adhesion Cell Surface Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cellular Response To Organonitrogen Compound Signal Transduction Cellular Response To Indole-3-methanol Cell Junction Assembly Regulation Of ERK1 And ERK2 Cascade Cell Adhesion Cellular Response To Stimulus Positive Regulation Of Signal Transduction Regulation Of MAPK Cascade Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Cell Adhesion Response To Stimulus Regulation Of Signal Transduction Response To Wounding Positive Regulation Of MAPK Cascade Regulation Of Signaling Positive Regulation Of Intracellular Signal Transduction Response To Organonitrogen Compound Cell Migration Cell Motility Wound Healing Response To Growth Factor Regulation Of Intracellular Signal Transduction Platelet Activation Organ Development Cellular Response To Organic Substance Cellular Component Assembly Cell Activation Blood Coagulation Regulation Of Cellular Localization Hemostasis Response To Organic Substance Movement Of Cell Or Subcellular Component Cell-cell Junction Assembly Protein Heterooligomerization Negative Regulation Of Signaling Regulation Of Protein Localization System Development Peptidyl-tyrosine Phosphorylation Response To Stress Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Phosphorylation
Tagcloud ?		al7a1 arhgap1 c25h16orf71 conceptus ddx58 degs endometria ensbtat00000050193 estrus fbxl7 herc6 ifi16 ifnt insemination lims2 loc507810 mgc127874 mgc128929 parp12 rnaseq rnf213 samd9 serbp1 srgap2 tbc1d1 wbscr17 znfx1 zswim4 zxfx1	1beta bioreactor cd11b constructs dataset dioxepan dxo ec ecs engineered hif immunodeficient immunofluorescent implanted lactide leukocyte leukocytes lla migrating msc mscs multipotent pecam retrieved scaffolds subcutaneously toll transmigration umbilical
Tagcloud (Difference) ?		al7a1 arhgap1 c25h16orf71 conceptus ddx58 degs endometria ensbtat00000050193 estrus fbxl7 herc6 ifi16 ifnt insemination lims2 loc507810 mgc127874 mgc128929 parp12 rnaseq rnf213 samd9 serbp1 srgap2 tbc1d1 wbscr17 znfx1 zswim4 zxfx1	1beta bioreactor cd11b constructs dataset dioxepan dxo ec ecs engineered hif immunodeficient immunofluorescent implanted lactide leukocyte leukocytes lla migrating msc mscs multipotent pecam retrieved scaffolds subcutaneously toll transmigration umbilical
Tagcloud (Intersection) ?