F2RL2 and JAM2

Number of citations of the paper that reports this interaction (PMID 12953056)
42

Data Source:
HPRD (in vitro, in vivo)

		F2RL2	JAM2
Gene Name		coagulation factor II (thrombin) receptor-like 2	junctional adhesion molecule 2
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Plasma Membrane Integral Component Of Plasma Membrane Apical Plasma Membrane	Plasma Membrane Integral Component Of Plasma Membrane Tight Junction
	Molecular Function	Phosphatidylinositol Phospholipase C Activity Protein Binding Thrombin Receptor Activity	Protein Binding Protein Heterodimerization Activity
	Biological Process	Blood Coagulation Metabolic Process Response To Wounding Platelet Activation Thrombin Receptor Signaling Pathway	Negative Regulation Of Cell Adhesion Blood Coagulation Single Organismal Cell-cell Adhesion Extracellular Matrix Organization Leukocyte Migration
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) G alpha (q) signalling events Signaling by GPCR Class A/1 (Rhodopsin-like receptors) Metabolic disorders of biological oxidation enzymes GPCR ligand binding G alpha (q) signalling events Thrombin signalling through proteinase activated receptors (PARs) GPCR downstream signaling Peptide ligand-binding receptors Gastrin-CREB signalling pathway via PKC and MAPK Platelet activation, signaling and aggregation	Integrin cell surface interactions Cell surface interactions at the vascular wall
Drugs
Diseases
GWAS			Cognitive performance ( 19734545)
Protein-Protein Interactions		8 interactors: CDH5 CTSG ECT2 F11R F2 F2RL3 JAM2 JAM3	9 interactors: CSNK1A1L F2RL2 GPR20 JAM3 NME3 SOX8 TDP2 TJP1 YBX1
Entrez ID		2151	58494
HPRD ID		03561	06041
Ensembl ID		ENSG00000164220	ENSG00000154721
Uniprot IDs		O00254	P57087
PDB IDs
Enriched GO Terms of Interacting Partners?		Blood Coagulation Hemostasis Regulation Of Body Fluid Levels Wound Healing Leukocyte Migration Response To Wounding Extracellular Matrix Organization Extracellular Structure Organization Response To Stress Cell Junction Assembly Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Cell-cell Junction Organization Positive Regulation Of Intracellular Transport Positive Regulation Of Calcium Ion Transport Into Cytosol Cell Migration Tight Junction Assembly Cell Motility Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Response To Stimulus Apical Junction Assembly Immune System Process Inflammatory Response Regulation Of Calcium Ion Transport Into Cytosol Regulation Of Intracellular Transport Regulation Of Actin Cytoskeleton Organization By Cell-cell Adhesion Positive Regulation Of Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Cell Adhesion Positive Regulation Of Calcium Ion Transport Locomotion Regulation Of Cytoskeleton Organization Defense Response Neutrophil Mediated Killing Of Gram-positive Bacterium Cell-cell Junction Assembly Movement Of Cell Or Subcellular Component Regulation Of Ion Homeostasis Positive Regulation Of Transport Regulation Of Blood Pressure Cell Surface Receptor Signaling Pathway Regulation Of Calcium Ion Transport Platelet Activation Positive Regulation Of Ion Transport Establishment Of Endothelial Intestinal Barrier Regulation Of Cellular Component Organization Killing By Host Of Symbiont Cells Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Organelle Organization Myeloid Progenitor Cell Differentiation Signaling Platelet Dense Granule Organization Blood Vessel Maturation	Negative Regulation Of Muscle Cell Differentiation Regulation Of Actin Cytoskeleton Organization By Cell-cell Adhesion Cell-cell Signaling Involved In Cell-cell Junction Organization In Utero Embryonic Development Retinal Rod Cell Differentiation Signaling Cell Communication Renal Vesicle Induction Astrocyte Fate Commitment Metanephric Nephron Tubule Formation Response To Magnetism Negative Regulation Of Photoreceptor Cell Differentiation Regulation Of Muscle Cell Differentiation CRD-mediated MRNA Stabilization Regulation Of Cellular Process Ureter Morphogenesis Metanephric Tubule Formation Establishment Of Endothelial Intestinal Barrier Chordate Embryonic Development Cellular Response To Stimulus Embryo Development Ending In Birth Or Egg Hatching Epithelial Cell Development Metanephric Nephron Tubule Morphogenesis Myeloid Progenitor Cell Differentiation
Tagcloud ?		al7a1 arhgap1 c25h16orf71 conceptus ddx58 degs endometria ensbtat00000050193 estrus fbxl7 herc6 ifi16 ifnt insemination lims2 loc507810 mgc127874 mgc128929 parp12 rnaseq rnf213 samd9 serbp1 srgap2 tbc1d1 wbscr17 znfx1 zswim4 zxfx1	angptl4 api5 asap1 cebpb cpp ctbbd1 homer1 itgb6 letm1 methylphenidate mitochondrion nfkbia notch3 nsbp1 overrepresented pcdh10 per3 perp pfc prps18c reinforcer s100a9 shrs sik1 stimulant taf1 ube2d2 uqcrc2 usp27x
Tagcloud (Difference) ?		al7a1 arhgap1 c25h16orf71 conceptus ddx58 degs endometria ensbtat00000050193 estrus fbxl7 herc6 ifi16 ifnt insemination lims2 loc507810 mgc127874 mgc128929 parp12 rnaseq rnf213 samd9 serbp1 srgap2 tbc1d1 wbscr17 znfx1 zswim4 zxfx1	angptl4 api5 asap1 cebpb cpp ctbbd1 homer1 itgb6 letm1 methylphenidate mitochondrion nfkbia notch3 nsbp1 overrepresented pcdh10 per3 perp pfc prps18c reinforcer s100a9 shrs sik1 stimulant taf1 ube2d2 uqcrc2 usp27x
Tagcloud (Intersection) ?