F2RL2 and F11R

Number of citations of the paper that reports this interaction (PMID 17057644)
27

Data Source:
HPRD (in vitro)

		F2RL2	F11R
Gene Name		coagulation factor II (thrombin) receptor-like 2	F11 receptor
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Plasma Membrane Integral Component Of Plasma Membrane Apical Plasma Membrane	Plasma Membrane Cell-cell Junction Tight Junction Microtubule Cytoskeleton Integral Component Of Membrane Cell Junction Cytoplasmic Vesicle Slit Diaphragm Extracellular Vesicular Exosome
	Molecular Function	Phosphatidylinositol Phospholipase C Activity Protein Binding Thrombin Receptor Activity	Protein Binding PDZ Domain Binding
	Biological Process	Blood Coagulation Metabolic Process Response To Wounding Platelet Activation Thrombin Receptor Signaling Pathway	Inflammatory Response Cell Adhesion Transforming Growth Factor Beta Receptor Signaling Pathway Blood Coagulation Response To Radiation Viral Process Extracellular Matrix Organization Actomyosin Structure Organization Positive Regulation Of Rap GTPase Activity Negative Regulation Of Rho GTPase Activity Cell Junction Assembly Cell-cell Junction Organization Positive Regulation Of Blood Pressure Intestinal Absorption Leukocyte Migration Tight Junction Assembly Establishment Of Protein Localization To Plasma Membrane Establishment Of Endothelial Intestinal Barrier Regulation Of Membrane Permeability Regulation Of Actin Cytoskeleton Reorganization
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) G alpha (q) signalling events Signaling by GPCR Class A/1 (Rhodopsin-like receptors) Metabolic disorders of biological oxidation enzymes GPCR ligand binding G alpha (q) signalling events Thrombin signalling through proteinase activated receptors (PARs) GPCR downstream signaling Peptide ligand-binding receptors Gastrin-CREB signalling pathway via PKC and MAPK Platelet activation, signaling and aggregation	Loss of Function of TGFBR2 in Cancer Cell junction organization TGFBR2 MSI Frameshift Mutants in Cancer TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) SMAD2/3 Phosphorylation Motif Mutants in Cancer Tight junction interactions Loss of Function of SMAD2/3 in Cancer TGFBR2 Kinase Domain Mutants in Cancer SMAD2/3 MH2 Domain Mutants in Cancer Loss of Function of SMAD4 in Cancer TGFBR1 KD Mutants in Cancer TGFBR1 LBD Mutants in Cancer Loss of Function of TGFBR1 in Cancer Cell surface interactions at the vascular wall Cell-cell junction organization Signaling by TGF-beta Receptor Complex Signaling by TGF-beta Receptor Complex in Cancer Integrin cell surface interactions SMAD4 MH2 Domain Mutants in Cancer
Drugs
Diseases
GWAS			Inflammatory bowel disease ( 23128233)
Protein-Protein Interactions		8 interactors: CDH5 CTSG ECT2 F11R F2 F2RL3 JAM2 JAM3	16 interactors: ASIP BDNF CASK CGN CSNK2A1 F2RL2 ITGAL MLLT4 MPDZ PARD3 PEX19 PICK1 PRKCA PTPRB SGTA TJP1
Entrez ID		2151	50848
HPRD ID		03561	12038
Ensembl ID		ENSG00000164220	ENSG00000158769
Uniprot IDs		O00254	B7Z941 Q6FIB4 Q9Y624
PDB IDs			1NBQ 3EOY 3TSZ
Enriched GO Terms of Interacting Partners?		Blood Coagulation Hemostasis Regulation Of Body Fluid Levels Wound Healing Leukocyte Migration Response To Wounding Extracellular Matrix Organization Extracellular Structure Organization Response To Stress Cell Junction Assembly Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Cell-cell Junction Organization Positive Regulation Of Intracellular Transport Positive Regulation Of Calcium Ion Transport Into Cytosol Cell Migration Tight Junction Assembly Cell Motility Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Response To Stimulus Apical Junction Assembly Immune System Process Inflammatory Response Regulation Of Calcium Ion Transport Into Cytosol Regulation Of Intracellular Transport Regulation Of Actin Cytoskeleton Organization By Cell-cell Adhesion Positive Regulation Of Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Cell Adhesion Positive Regulation Of Calcium Ion Transport Locomotion Regulation Of Cytoskeleton Organization Defense Response Neutrophil Mediated Killing Of Gram-positive Bacterium Cell-cell Junction Assembly Movement Of Cell Or Subcellular Component Regulation Of Ion Homeostasis Positive Regulation Of Transport Regulation Of Blood Pressure Cell Surface Receptor Signaling Pathway Regulation Of Calcium Ion Transport Platelet Activation Positive Regulation Of Ion Transport Establishment Of Endothelial Intestinal Barrier Regulation Of Cellular Component Organization Killing By Host Of Symbiont Cells Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Organelle Organization Myeloid Progenitor Cell Differentiation Signaling Platelet Dense Granule Organization Blood Vessel Maturation	Cell Junction Assembly Cell-cell Junction Organization Cell-cell Junction Assembly Establishment Of Endothelial Intestinal Barrier Signal Transduction Epithelial Cell Development Membrane Organization Cell-cell Signaling Signaling Cell Communication Anatomical Structure Development Protein Localization To Membrane Cell Development Cellular Response To Stimulus Developmental Process Establishment Of Endothelial Barrier Epithelial Cell Differentiation Cell Surface Receptor Signaling Pathway Endothelial Cell Development Tight Junction Assembly Regulation Of Body Fluid Levels Cellular Response To Growth Factor Stimulus Epithelial Cell Morphogenesis Epithelium Development Anatomical Structure Morphogenesis Protein Kinase C-activating G-protein Coupled Receptor Signaling Pathway Wound Healing Response To Growth Factor Receptor Clustering Tissue Development G-protein Coupled Receptor Signaling Pathway Cell-cell Signaling Involved In Cell-cell Junction Organization Response To Anesthetic Negative Regulation Of Lipid Binding Positive Regulation Of Dense Core Granule Biogenesis Response To Fluoxetine Response To L-glutamate Cell Differentiation Cell Adhesion Chaperone-mediated Protein Folding Negative Regulation Of Synaptic Transmission Cellular Response To Organic Substance Response To Wounding Response To Stimulus Locomotion Apical Junction Assembly Cell Morphogenesis Involved In Differentiation Endothelial Cell Differentiation Cellular Response To Carbohydrate Stimulus Multicellular Organismal Development
Tagcloud ?		al7a1 arhgap1 c25h16orf71 conceptus ddx58 degs endometria ensbtat00000050193 estrus fbxl7 herc6 ifi16 ifnt insemination lims2 loc507810 mgc127874 mgc128929 parp12 rnaseq rnf213 samd9 serbp1 srgap2 tbc1d1 wbscr17 znfx1 zswim4 zxfx1
Tagcloud (Difference) ?		al7a1 arhgap1 c25h16orf71 conceptus ddx58 degs endometria ensbtat00000050193 estrus fbxl7 herc6 ifi16 ifnt insemination lims2 loc507810 mgc127874 mgc128929 parp12 rnaseq rnf213 samd9 serbp1 srgap2 tbc1d1 wbscr17 znfx1 zswim4 zxfx1
Tagcloud (Intersection) ?