F2RL2 and F11R

Number of citations of the paper that reports this interaction (PubMedID 17057644)
19

Data Source:
HPRD (in vitro)

		F2RL2	F11R
Description		coagulation factor II thrombin receptor like 2	F11 receptor
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Plasma Membrane Membrane Apical Plasma Membrane Protein-containing Complex	Plasma Membrane Cell-cell Junction Bicellular Tight Junction Membrane Cell Junction Protein-containing Complex Extracellular Exosome Tight Junction Anchoring Junction
	Molecular Function	Proteinase-activated Receptor Activity Phosphatidylinositol-4,5-bisphosphate Phospholipase C Activity G Protein-coupled Receptor Activity Protein Binding Thrombin-activated Receptor Activity Receptor Ligand Activity	Virus Receptor Activity Integrin Binding Protein Binding PDZ Domain Binding Protein Homodimerization Activity Cadherin Binding
	Biological Process	Signal Transduction G Protein-coupled Receptor Signaling Pathway Blood Coagulation Hemostasis Response To Wounding Platelet Activation Positive Regulation Of Insulin Secretion Regulation Of Biological Quality Thrombin-activated Receptor Signaling Pathway Ligand-gated Ion Channel Signaling Pathway	Regulation Of Cytokine Production System Process Inflammatory Response Cell Adhesion Leukocyte Cell-cell Adhesion Regulation Of Cell Shape Cell Differentiation Epithelial Cell Differentiation Actomyosin Structure Organization Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Rho Protein Signal Transduction Maintenance Of Blood-brain Barrier Memory T Cell Extravasation Symbiont Entry Into Host Cell Intestinal Absorption Leukocyte Migration Regulation Of Cytoskeleton Organization Negative Regulation Of Stress Fiber Assembly Regulation Of Biological Quality Cellular Response To Mechanical Stimulus Protein Localization To Plasma Membrane Establishment Of Endothelial Intestinal Barrier Regulation Of Membrane Permeability Cell-cell Adhesion Positive Regulation Of Platelet Aggregation Protein Localization To Bicellular Tight Junction Positive Regulation Of Establishment Of Endothelial Barrier Regulation Of Bicellular Tight Junction Assembly
Pathways		Peptide ligand-binding receptors G alpha (q) signalling events Thrombin signalling through proteinase activated receptors (PARs) Thrombin signalling through proteinase activated receptors (PARs)	Cell surface interactions at the vascular wall Integrin cell surface interactions TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) Tight junction interactions
Drugs
Diseases
GWAS		Mean platelet volume ( 28031487) Phenylephrine infusion rate during anesthesia ( 31455332)	Inflammatory bowel disease ( 23128233) Night sleep phenotypes ( 27126917)
Interacting Genes		8 interacting genes: CDH5 CTSG ECT2 F11R F2 F2RL3 JAM2 JAM3	30 interacting genes: AFDN ASIP BDNF CAMLG CASK CGN CSNK2A1 F2RL2 ITGAL JAGN1 MARCHF2 MMP14 MPDZ MYADM PARD3 PEX19 PGAP2 PICK1 PRKCA PTPRB RABAC1 SGTA SLC30A2 SLC35A1 SNAP47 STRIT1 TJP1 TMEM100 TMEM147 TMEM86B
Entrez ID		2151	50848
HPRD ID		03561	12038
Ensembl ID		ENSG00000164220	ENSG00000158769
Uniprot IDs		O00254	Q6FIB4 Q9Y624
PDB IDs			1NBQ 3EOY 3TSZ 4ODB
Enriched GO Terms of Interacting Partners?		Maintenance Of Blood-brain Barrier Bicellular Tight Junction Cell-cell Junction Anchoring Junction Tight Junction Cell-cell Adhesion Anatomical Structure Homeostasis Tissue Homeostasis Regulation Of Platelet Activation Hematopoietic Stem Cell Migration To Bone Marrow Protein Complex Involved In Cell Adhesion Positive Regulation Of Establishment Of Endothelial Barrier Protein Localization To Bicellular Tight Junction Leukocyte Migration Platelet Activation Hematopoietic Stem Cell Migration Protein Localization To Cell Junction Neutrophil-mediated Killing Of Bacterium Thrombin-activated Receptor Signaling Pathway Positive Regulation Of Platelet Aggregation Cell-cell Junction Assembly Cell Adhesion Regulation Of Establishment Of Endothelial Barrier Cellular Extravasation Protein Localization To Cell-cell Junction Cell Migration Positive Regulation Of Homotypic Cell-cell Adhesion Integrin Binding Neutrophil Mediated Immunity Multicellular Organismal-level Homeostasis Cell-cell Contact Zone Cell-cell Junction Organization Cell Motility Regulation Of Cytoskeleton Organization Regulation Of Platelet Aggregation Killing By Host Of Symbiont Cells Cell-cell Adhesion Mediator Activity Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Biological Process Involved In Interaction With Symbiont Regulation Of Endothelial Cell Differentiation Homeostatic Process Bicellular Tight Junction Assembly Cell Junction Assembly Tight Junction Assembly Adherens Junction Organization Tight Junction Organization Leukocyte Cell-cell Adhesion Positive Regulation Of Calcium Ion Transmembrane Transport Biofilm Matrix Disassembly Regulation Of Cytokinesis, Actomyosin Contractile Ring Assembly	Localization Within Membrane Plasma Membrane Membrane Cell-cell Junction Organization Establishment Of Protein Localization To Membrane Cell-cell Junction Assembly Cell Junction Assembly Cell Junction Organization Protein Insertion Into ER Membrane Cell Junction Cellular Localization Tight Junction Establishment Of Endothelial Barrier Endothelial Cell Development Bicellular Tight Junction Tight Junction Assembly Tight Junction Organization Positive Regulation Of Cell-cell Adhesion Mediated By Cadherin Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process Protein Localization To Membrane Regulation Of Insulin Secretion Protein Insertion Into Membrane Cellular Component Maintenance Establishment Of Protein Localization Establishment Of Endothelial Intestinal Barrier Tail-anchored Membrane Protein Insertion Into ER Membrane Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Peptide Hormone Secretion Protein Targeting Cell-cell Junction Regulation Of Actin Filament-based Process Cell Adhesion Molecule Binding Cell-cell Junction Maintenance Signaling Receptor Binding Anchoring Junction Intracellular Protein Localization Regulation Of Protein Localization Positive Regulation Of Calcium Ion Import Regulation Of Cell Junction Assembly Regulation Of Hormone Secretion Regulation Of Protein Secretion Glial Cell Migration Apical Junction Complex Regulation Of Actin Filament Organization Negative Regulation Of Protein Catabolic Process Melanocortin Receptor Binding Epithelial Cell Development Cellular Response To Genistein Negative Regulation Of GDF15-GFRAL Signaling Pathway
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