PHF1 and DPF1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		PHF1	DPF1
Description		PHD finger protein 1	double PHD fingers 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Centrosome Cytosol Cytoskeleton ESC/E(Z) Complex Site Of Double-strand Break	Chromatin Nucleus Nucleoplasm Cytoplasm NBAF Complex
	Molecular Function	Transcription Corepressor Binding DNA Binding Chromatin Binding Protein Binding Zinc Ion Binding Identical Protein Binding Metal Ion Binding Histone H3K4me3 Reader Activity Histone H3K36me3 Reader Activity Histone Methyltransferase Binding	Protein Binding Zinc Ion Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Chromatin Organization DNA Damage Response Negative Regulation Of Gene Expression, Epigenetic DNA Repair-dependent Chromatin Remodeling	Chromatin Remodeling Regulation Of Transcription By RNA Polymerase II Apoptotic Process Nervous System Development Regulation Of Mitotic Metaphase/anaphase Transition Positive Regulation Of Cell Differentiation Regulation Of G0 To G1 Transition Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Double-strand Break Repair Regulation Of Nucleotide-excision Repair
Pathways		PRC2 methylates histones and DNA	Regulation of MITF-M-dependent genes involved in pigmentation Regulation of MITF-M-dependent genes involved in pigmentation Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) Formation of the canonical BAF (cBAF) complex Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)
Drugs
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Body mass index ( 26426971) Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143) Refractive error ( 32231278)	Amyotrophic lateral sclerosis (sporadic) ( 24529757)
Interacting Genes		77 interacting genes: ABI2 ARID5A ARRDC3 ATXN7L1 AVPI1 BHLHE40 BIRC7 BOLL CALCOCO2 CSTPP1 DISC1 DPF1 DYSF EFHC2 EZH2 FHL2 FOSB GOLGA6L9 GPKOW GPRASP3 H3C1 H3C10 H3C11 H3C12 H3C2 H3C3 H3C6 H3C7 H3C8 H4C1 HOMEZ HSD17B14 INCA1 IRAK1BP1 KIAA0408 KRT40 LBX1 LZTS2 MAGED1 MDFI MEOX2 MORN3 NAB2 NEK6 PATZ1 PDLIM7 PFDN5 PIBF1 PRR20A PRR20B PRR20C PRR20D PRR20E RBBP8NL RBPMS SMG9 SORBS3 SPAG8 TFCP2 TFIP11 THAP1 TLE5 TNS2 TOX2 TP53BP2 TRIM23 USP54 VAC14 ZBTB10 ZBTB16 ZIM2 ZNF500 ZNF526 ZNF688 ZNF71 ZRANB1 ZSCAN32	3 interacting genes: PHF1 PTGER4 RPN1
Entrez ID		5252	8193
HPRD ID		04195	03393
Ensembl ID		ENSG00000112511	ENSG00000011332
Uniprot IDs		A0A140VJR4 A0A1U9X8A3 O43189	A0A804CCM0 A0A804CYY4 A0A8I5QL29 C8C3P2 E9PDV3 J3KQY6 Q6PJ73 Q92782
PDB IDs		2E5P 2M0O 4HCZ 5XFN 5XFO 5XFP 6WAT 6WAV 7LKY 8H43
Enriched GO Terms of Interacting Partners?		Nucleosome Assembly Structural Constituent Of Chromatin Nucleosome Organization Telomere Organization Nucleosome Protein-DNA Complex Assembly Nucleus DNA Binding Protein Heterodimerization Activity Chromosome Organization Epigenetic Regulation Of Gene Expression Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Protein-containing Complex Protein Binding Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Gene Expression Chromatin Remodeling Cadherin Binding Identical Protein Binding Regulation Of Transcription By RNA Polymerase II Chromosome Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Chromatin Organization Transcription Factor Binding Nucleoplasm Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Transcription Corepressor Activity Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Primary Metabolic Process Transcription Corepressor Binding Protein-containing Complex Assembly Protein-containing Complex Organization	Negative Regulation Of Eosinophil Extravasation Prostaglandin E Receptor Activity Negative Regulation Of Integrin Activation Negative Regulation Of Eosinophil Migration Prostaglandin Receptor Activity Dolichyl-diphosphooligosaccharide-protein Glycotransferase Activity Histone H3K36me3 Reader Activity Oligosaccharyltransferase Complex B Negative Regulation Of Cellular Extravasation Oligosaccharyltransferase Complex A Oligosaccharyltransferase Complex ESC/E(Z) Complex Histone Methyltransferase Binding Regulation Of Integrin Activation Cellular Response To Prostaglandin E Stimulus Histone H3K4me3 Reader Activity Protein N-linked Glycosylation Via Asparagine DNA Repair-dependent Chromatin Remodeling Cellular Response To Prostaglandin Stimulus Response To Prostaglandin E
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