PHF1 and IRAK1BP1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		PHF1	IRAK1BP1
Description		PHD finger protein 1	interleukin 1 receptor associated kinase 1 binding protein 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Centrosome Cytosol Cytoskeleton ESC/E(Z) Complex Site Of Double-strand Break	Nucleus Cytoplasm
	Molecular Function	Transcription Corepressor Binding DNA Binding Chromatin Binding Protein Binding Zinc Ion Binding Identical Protein Binding Metal Ion Binding Histone H3K4me3 Reader Activity Histone H3K36me3 Reader Activity Histone Methyltransferase Binding	Protein Binding Signaling Adaptor Activity
	Biological Process	Chromatin Organization DNA Damage Response Negative Regulation Of Gene Expression, Epigenetic DNA Repair-dependent Chromatin Remodeling	Immune Response Positive Regulation Of Canonical NF-kappaB Signal Transduction
Pathways		PRC2 methylates histones and DNA
Drugs
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Body mass index ( 26426971) Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143) Refractive error ( 32231278)	Blood pressure measurement (high sodium and potassium intervention) ( 24165912) Blood pressure measurement (high sodium intervention) ( 24165912) Blood pressure measurement (low sodium intervention) ( 24165912) Cadmium levels ( 26025379) Daytime nap ( 33568662) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Late-onset Alzheimer's disease ( 27770636) LDL cholesterol levels x loop diuretics use interaction ( 31806883) Macular thickness ( 30535121) Sjögren's syndrome ( 24097067)
Interacting Genes		77 interacting genes: ABI2 ARID5A ARRDC3 ATXN7L1 AVPI1 BHLHE40 BIRC7 BOLL CALCOCO2 CSTPP1 DISC1 DPF1 DYSF EFHC2 EZH2 FHL2 FOSB GOLGA6L9 GPKOW GPRASP3 H3C1 H3C10 H3C11 H3C12 H3C2 H3C3 H3C6 H3C7 H3C8 H4C1 HOMEZ HSD17B14 INCA1 IRAK1BP1 KIAA0408 KRT40 LBX1 LZTS2 MAGED1 MDFI MEOX2 MORN3 NAB2 NEK6 PATZ1 PDLIM7 PFDN5 PIBF1 PRR20A PRR20B PRR20C PRR20D PRR20E RBBP8NL RBPMS SMG9 SORBS3 SPAG8 TFCP2 TFIP11 THAP1 TLE5 TNS2 TOX2 TP53BP2 TRIM23 USP54 VAC14 ZBTB10 ZBTB16 ZIM2 ZNF500 ZNF526 ZNF688 ZNF71 ZRANB1 ZSCAN32	11 interacting genes: IRAK1 MISP PHF1 PRKAB2 RELA RIPPLY1 SCNM1 TFCP2 UFL1 USP20 ZNF410
Entrez ID		5252	134728
HPRD ID		04195	17157
Ensembl ID		ENSG00000112511	ENSG00000146243
Uniprot IDs		A0A140VJR4 A0A1U9X8A3 O43189	Q5VVH5
PDB IDs		2E5P 2M0O 4HCZ 5XFN 5XFO 5XFP 6WAT 6WAV 7LKY 8H43
Enriched GO Terms of Interacting Partners?		Nucleosome Assembly Structural Constituent Of Chromatin Nucleosome Organization Telomere Organization Nucleosome Protein-DNA Complex Assembly Nucleus DNA Binding Protein Heterodimerization Activity Chromosome Organization Epigenetic Regulation Of Gene Expression Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Protein-containing Complex Protein Binding Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Gene Expression Chromatin Remodeling Cadherin Binding Identical Protein Binding Regulation Of Transcription By RNA Polymerase II Chromosome Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Chromatin Organization Transcription Factor Binding Nucleoplasm Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Transcription Corepressor Activity Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Primary Metabolic Process Transcription Corepressor Binding Protein-containing Complex Assembly Protein-containing Complex Organization	Canonical NF-kappaB Signal Transduction Antiviral Innate Immune Response Regulation Of Canonical NF-kappaB Signal Transduction Interleukin-1-mediated Signaling Pathway Protein Kinase Binding Positive Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell Regulation Of DNA-binding Transcription Factor Activity Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell Toll-like Receptor 4 Signaling Pathway Cell Surface Toll-like Receptor Signaling Pathway Toll-like Receptor Signaling Pathway Innate Immune Response Cell Surface Pattern Recognition Receptor Signaling Pathway Positive Regulation Of Leukocyte Cell-cell Adhesion Defense Response To Virus UFM1 Ligase Activity Positive Regulation Of Gliogenesis Positive Regulation Of Cell-cell Adhesion Response To Interleukin-1 Defense Response To Other Organism Positive Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Intracellular Signal Transduction Protein-containing Complex Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Defense Response To Symbiont NF-kappaB P50/p65 Complex UFM1 Transferase Activity Negative Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Leukocyte Cell-cell Adhesion Cytoplasmic Pattern Recognition Receptor Signaling Pathway Regulation Of Metabolic Process Site Of Double-strand Break Regulation Of Gliogenesis Positive Regulation Of Schwann Cell Differentiation Response To Virus Negative Regulation Of Post-translational Protein Modification Response To Cobalamin Positive Regulation Of Reticulophagy Mitotic Spindle Astral Microtubule End Positive Regulation Of Metabolic Process Positive Regulation Of DNA-binding Transcription Factor Activity Response To Amino Acid Toll-like Receptor TLR6:TLR2 Signaling Pathway Regulation Of Schwann Cell Differentiation NF-kappaB Complex Prolactin Signaling Pathway Regulation Of Reticulophagy Postsynapse To Nucleus Signaling Pathway Protein K69-linked Ufmylation Somite Specification
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