PHF1

Gene Name		PHD finger protein 1
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Microtubule Organizing Center ESC/E(Z) Complex Site Of Double-strand Break
	Molecular Function	Sequence-specific DNA Binding Transcription Factor Activity Zinc Ion Binding Methylated Histone Binding
	Biological Process	Transcription, DNA-templated Regulation Of Transcription, DNA-templated Cellular Response To DNA Damage Stimulus Gene Expression Chromatin Modification Regulation Of Gene Expression, Epigenetic Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of Histone H3-K27 Methylation Positive Regulation Of Histone H3-K27 Methylation
Pathways		Epigenetic regulation of gene expression PRC2 methylates histones and DNA
Drugs
Diseases
GWAS
Protein-protein Interactions		22 interactors: ATXN7L1 BIRC7 CALCOCO2 EZH2 HIST1H3A HIST1H3B HIST1H3C HIST1H3E HIST1H3F HIST1H3G HIST1H3H HIST1H3I HIST1H3J HSD17B14 NAB2 NEK6 PDLIM7 RBPMS TFCP2 THAP1 TRIM23 VAC14
Entrez ID		5252
HPRD ID		04195
Ensembl ID		ENSG00000112511
Uniprot IDs		O43189
PDB IDs		2E5P 2M0O 4HCZ
Enriched GO Terms of Interacting Partners?		DNA Replication-dependent Nucleosome Assembly DNA Methylation On Cytosine Chromatin Silencing At RDNA Regulation Of Gene Silencing DNA Methylation Chromatin Silencing Negative Regulation Of Gene Expression, Epigenetic DNA Modification Gene Silencing Nucleosome Assembly Regulation Of Gene Expression, Epigenetic Chromatin Assembly Nucleosome Organization Chromatin Assembly Or Disassembly Protein-DNA Complex Assembly DNA Packaging Methylation DNA Conformation Change Wound Healing Blood Coagulation Hemostasis Response To Wounding Chromatin Organization Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Body Fluid Levels Cellular Macromolecular Complex Assembly Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Chromosome Organization Protein Complex Assembly DNA Metabolic Process Negative Regulation Of Cellular Metabolic Process Gene Expression Regulation Of Metabolic Process Response To Stress Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Cellular Component Assembly Regulation Of RNA Metabolic Process Organelle Organization Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process
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