PHF1 and NAB2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		PHF1	NAB2
Description		PHD finger protein 1	NGFI-A binding protein 2
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Centrosome Cytosol Cytoskeleton ESC/E(Z) Complex Site Of Double-strand Break	Nucleus Nucleoplasm
	Molecular Function	Transcription Corepressor Binding DNA Binding Chromatin Binding Protein Binding Zinc Ion Binding Identical Protein Binding Metal Ion Binding Histone H3K4me3 Reader Activity Histone H3K36me3 Reader Activity Histone Methyltransferase Binding	Transcription Coregulator Activity Transcription Corepressor Activity Protein Binding Identical Protein Binding
	Biological Process	Chromatin Organization DNA Damage Response Negative Regulation Of Gene Expression, Epigenetic DNA Repair-dependent Chromatin Remodeling	Endochondral Ossification Regulation Of DNA-templated Transcription Schwann Cell Differentiation Negative Regulation Of Transcription By RNA Polymerase III Myelination Regulation Of Epidermis Development Negative Regulation Of DNA-templated Transcription
Pathways		PRC2 methylates histones and DNA	NGF-stimulated transcription NGF-stimulated transcription EGR2 and SOX10-mediated initiation of Schwann cell myelination
Drugs
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Body mass index ( 26426971) Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143) Refractive error ( 32231278)	Allergic disease (asthma, hay fever or eczema) ( 29785011) Asthma ( 29273806 31361310 31619474 31959851) Asthma (adult onset) ( 31036433) Asthma (childhood onset) ( 31036433) Asthma or allergic disease (pleiotropy) ( 29785011) Bipolar disorder ( 31043756) IgE levels ( 22075330) Schizophrenia ( 25056061 29483656)
Interacting Genes		77 interacting genes: ABI2 ARID5A ARRDC3 ATXN7L1 AVPI1 BHLHE40 BIRC7 BOLL CALCOCO2 CSTPP1 DISC1 DPF1 DYSF EFHC2 EZH2 FHL2 FOSB GOLGA6L9 GPKOW GPRASP3 H3C1 H3C10 H3C11 H3C12 H3C2 H3C3 H3C6 H3C7 H3C8 H4C1 HOMEZ HSD17B14 INCA1 IRAK1BP1 KIAA0408 KRT40 LBX1 LZTS2 MAGED1 MDFI MEOX2 MORN3 NAB2 NEK6 PATZ1 PDLIM7 PFDN5 PIBF1 PRR20A PRR20B PRR20C PRR20D PRR20E RBBP8NL RBPMS SMG9 SORBS3 SPAG8 TFCP2 TFIP11 THAP1 TLE5 TNS2 TOX2 TP53BP2 TRIM23 USP54 VAC14 ZBTB10 ZBTB16 ZIM2 ZNF500 ZNF526 ZNF688 ZNF71 ZRANB1 ZSCAN32	80 interacting genes: ANK3 ANKRD11 CBX8 CCDC187 CCDC33 CCDC57 CCHCR1 CDC23 CTAG1A CTAG1B CTNNA3 CWF19L2 DDX6 DGCR6 DGCR6L DRG2 EGR1 EGR2 ELOA ENKD1 EXOC8 FAM200C FAM9A GCC1 GOLGA6L9 HSF2BP JAKMIP2 KIF9 KIFC3 KRT34 KRT40 KRTAP10-3 KRTAP10-8 LENG1 LMNA LNX1 MAPK3 MCM7 MCRS1 MDFI MORF4L1 MORF4L2 NDOR1 NEDD9 NME7 NOTCH2NLA NTAQ1 PHF1 PHOSPHO2 PIK3R3 PIN1 PLOD3 PRKAA2 PRKAB2 PSMA1 QARS1 RBPMS RFC5 RINT1 SCNM1 SMARCD1 SORBS3 SPG21 SUMO1P1 TCEA2 TCEANC TCHP TGIF2LY TLE5 TRAF2 TRIM23 TSGA10 TSGA10IP TTC19 USP2 UTP14C ZMAT2 ZMYND12 ZMYND19 ZNF417
Entrez ID		5252	4665
HPRD ID		04195	03854
Ensembl ID		ENSG00000112511	ENSG00000166886
Uniprot IDs		A0A140VJR4 A0A1U9X8A3 O43189	Q15742
PDB IDs		2E5P 2M0O 4HCZ 5XFN 5XFO 5XFP 6WAT 6WAV 7LKY 8H43
Enriched GO Terms of Interacting Partners?		Nucleosome Assembly Structural Constituent Of Chromatin Nucleosome Organization Telomere Organization Nucleosome Protein-DNA Complex Assembly Nucleus DNA Binding Protein Heterodimerization Activity Chromosome Organization Epigenetic Regulation Of Gene Expression Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Protein-containing Complex Protein Binding Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Gene Expression Chromatin Remodeling Cadherin Binding Identical Protein Binding Regulation Of Transcription By RNA Polymerase II Chromosome Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Chromatin Organization Transcription Factor Binding Nucleoplasm Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Transcription Corepressor Activity Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Primary Metabolic Process Transcription Corepressor Binding Protein-containing Complex Assembly Protein-containing Complex Organization
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