PHF1 and FOSB

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		PHF1	FOSB
Description		PHD finger protein 1	FosB proto-oncogene, AP-1 transcription factor subunit
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Centrosome Cytosol Cytoskeleton ESC/E(Z) Complex Site Of Double-strand Break	Chromatin Nucleus Nucleoplasm Cytosol
	Molecular Function	Transcription Corepressor Binding DNA Binding Chromatin Binding Protein Binding Zinc Ion Binding Identical Protein Binding Metal Ion Binding Histone H3K4me3 Reader Activity Histone H3K36me3 Reader Activity Histone Methyltransferase Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Double-stranded DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Chromatin Organization DNA Damage Response Negative Regulation Of Gene Expression, Epigenetic DNA Repair-dependent Chromatin Remodeling	Negative Regulation Of Transcription By RNA Polymerase II Response To Amphetamine Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Female Pregnancy Response To Xenobiotic Stimulus Response To Mechanical Stimulus Response To Progesterone Cellular Response To Hormone Stimulus Response To Nicotine Response To Cocaine Response To Morphine Response To Ethanol Positive Regulation Of Transcription By RNA Polymerase II Behavioral Response To Cocaine Response To Corticosterone Response To CAMP Cellular Response To Calcium Ion
Pathways		PRC2 methylates histones and DNA	Estrogen-dependent gene expression NGF-stimulated transcription NGF-stimulated transcription Regulation of PD-L1(CD274) transcription
Drugs
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Body mass index ( 26426971) Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143) Refractive error ( 32231278)	Alzheimer's disease or HDL levels (pleiotropy) ( 30805717) Heel bone mineral density ( 28869591 30598549)
Interacting Genes		77 interacting genes: ABI2 ARID5A ARRDC3 ATXN7L1 AVPI1 BHLHE40 BIRC7 BOLL CALCOCO2 CSTPP1 DISC1 DPF1 DYSF EFHC2 EZH2 FHL2 FOSB GOLGA6L9 GPKOW GPRASP3 H3C1 H3C10 H3C11 H3C12 H3C2 H3C3 H3C6 H3C7 H3C8 H4C1 HOMEZ HSD17B14 INCA1 IRAK1BP1 KIAA0408 KRT40 LBX1 LZTS2 MAGED1 MDFI MEOX2 MORN3 NAB2 NEK6 PATZ1 PDLIM7 PFDN5 PIBF1 PRR20A PRR20B PRR20C PRR20D PRR20E RBBP8NL RBPMS SMG9 SORBS3 SPAG8 TFCP2 TFIP11 THAP1 TLE5 TNS2 TOX2 TP53BP2 TRIM23 USP54 VAC14 ZBTB10 ZBTB16 ZIM2 ZNF500 ZNF526 ZNF688 ZNF71 ZRANB1 ZSCAN32	28 interacting genes: AGXT CENPO CREB5 CYTH4 DNMT3L ENKD1 EP300 FAM222B FAM90A1 FOXP3 GLIS2 JUNB JUND LINC00963 NCK2 NEDD9 NFE2L2 PHC2 PHF1 POGZ POU6F2 ROR2 SRA1 TENT5B TLE5 TLX3 VEZF1 ZC3H10
Entrez ID		5252	2354
HPRD ID		04195	01270
Ensembl ID		ENSG00000112511	ENSG00000125740
Uniprot IDs		A0A140VJR4 A0A1U9X8A3 O43189	P53539
PDB IDs		2E5P 2M0O 4HCZ 5XFN 5XFO 5XFP 6WAT 6WAV 7LKY 8H43	5VPA 5VPB 5VPC 5VPD 5VPE 5VPF 6UCI 6UCL 6UCM 7UCC 7UCD
Enriched GO Terms of Interacting Partners?		Nucleosome Assembly Structural Constituent Of Chromatin Nucleosome Organization Telomere Organization Nucleosome Protein-DNA Complex Assembly Nucleus DNA Binding Protein Heterodimerization Activity Chromosome Organization Epigenetic Regulation Of Gene Expression Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Protein-containing Complex Protein Binding Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Gene Expression Chromatin Remodeling Cadherin Binding Identical Protein Binding Regulation Of Transcription By RNA Polymerase II Chromosome Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Chromatin Organization Transcription Factor Binding Nucleoplasm Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Transcription Corepressor Activity Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Primary Metabolic Process Transcription Corepressor Binding Protein-containing Complex Assembly Protein-containing Complex Organization	Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Metabolic Process Regulation Of RNA Biosynthetic Process Regulation Of Gene Expression Regulation Of Transcription By RNA Polymerase II DNA Binding Regulation Of Macromolecule Biosynthetic Process Regulation Of T-helper 17 Cell Differentiation Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of RNA Biosynthetic Process Chromatin Regulation Of T-helper 17 Type Immune Response Positive Regulation Of DNA-templated Transcription DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription Factor AP-1 Complex Transcription Coregulator Binding Protein-DNA Complex DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Positive Regulation Of RNA Metabolic Process Regulation Of T-helper Cell Differentiation DNA-binding Transcription Factor Activity Regulation Of Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Positive Regulation Of Nucleobase-containing Compound Metabolic Process Nucleus Negative Regulation Of RNA Metabolic Process ESC/E(Z) Complex Sequence-specific Double-stranded DNA Binding Regulation Of CD4-positive, Alpha-beta T Cell Activation Nucleoplasm Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Cell Activation CD4-positive, Alpha-beta T Cell Lineage Commitment Regulation Of Cell Differentiation Zinc Ion Binding Alpha-beta T Cell Lineage Commitment CD4-positive Or CD8-positive, Alpha-beta T Cell Lineage Commitment Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Alpha-beta T Cell Activation Negative Regulation Of Macromolecule Metabolic Process L-serine-pyruvate Transaminase Activity T Cell Lineage Commitment
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