POLR3A and POLR3E

Number of citations of the paper that reports this interaction (PubMedID 35271311)
106

Data Source:
BioGRID (affinity chromatography technology, biochemical)
HPRD (in vivo, in vitro)

		POLR3A	POLR3E
Description		RNA polymerase III subunit A	RNA polymerase III subunit E
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GO Annotations	Cellular Component	DNA-directed RNA Polymerase Complex Nucleus Nucleoplasm RNA Polymerase III Complex Cytoplasm Cytosol Membrane	DNA-directed RNA Polymerase Complex Nucleus Nucleoplasm RNA Polymerase III Complex Cytosol
	Molecular Function	Magnesium Ion Binding DNA Binding Chromatin Binding DNA-directed RNA Polymerase Activity Protein Binding Zinc Ion Binding Transferase Activity Nucleotidyltransferase Activity 5'-3' RNA Polymerase Activity Metal Ion Binding DNA/RNA Hybrid Binding
	Biological Process	Immune System Process DNA-templated Transcription Positive Regulation Of Gene Expression Positive Regulation Of Interferon-beta Production TRNA Transcription By RNA Polymerase III Innate Immune Response Defense Response To Virus	Immune System Process DNA-templated Transcription Innate Immune Response Defense Response To Virus
Pathways		Cytosolic sensors of pathogen-associated DNA RNA Polymerase III Chain Elongation RNA Polymerase III Transcription Termination RNA Polymerase III Abortive And Retractive Initiation RNA Polymerase III Transcription Initiation From Type 1 Promoter RNA Polymerase III Transcription Initiation From Type 1 Promoter RNA Polymerase III Transcription Initiation From Type 2 Promoter RNA Polymerase III Transcription Initiation From Type 2 Promoter RNA Polymerase III Transcription Initiation From Type 3 Promoter RNA Polymerase III Transcription Initiation From Type 3 Promoter	Cytosolic sensors of pathogen-associated DNA RNA Polymerase III Chain Elongation RNA Polymerase III Transcription Termination RNA Polymerase III Abortive And Retractive Initiation RNA Polymerase III Transcription Initiation From Type 1 Promoter RNA Polymerase III Transcription Initiation From Type 1 Promoter RNA Polymerase III Transcription Initiation From Type 2 Promoter RNA Polymerase III Transcription Initiation From Type 2 Promoter RNA Polymerase III Transcription Initiation From Type 3 Promoter RNA Polymerase III Transcription Initiation From Type 3 Promoter
Drugs
Diseases
GWAS		Colorectal cancer or advanced adenoma ( 30510241) Executive function (trail making test B) ( 24629169)	Femur bone mineral density x serum urate levels interaction ( 34046847) Height ( 31562340) L-selectin levels ( 25576479)
Interacting Genes		6 interacting genes: EWSR1 IKBKG NEDD4 PCBD1 PKP2 POLR3E	2 interacting genes: POLR3A POLR3D
Entrez ID		11128	55718
HPRD ID		17879	15155
Ensembl ID		ENSG00000148606	ENSG00000058600
Uniprot IDs		O14802	A0A0C4DH01 Q9NVU0
PDB IDs		7A6H 7AE1 7AE3 7AEA 7AST 7D58 7D59 7DN3 7DU2 7FJI 7FJJ 8ITY 8IUE 8IUH 9FSO 9FSP 9FSQ 9FSR 9FSS	7A6H 7AE1 7AE3 7AEA 7AST 7ASU 7ASV 7D58 7D59 7DN3 7DU2 7FJI 7FJJ 8ITY 8IUE 8IUH 9FSO 9FSP 9FSQ 9FSR 9FSS
Enriched GO Terms of Interacting Partners?		Nucleoplasm Ubiquitin Ligase Complex Channel Inhibitor Activity Regulation Of Sodium Ion Transport Formation Of Structure Involved In A Symbiotic Process 4-alpha-hydroxytetrahydrobiopterin Dehydratase Activity Tyrosine Biosynthetic Process Phenylalanine 4-monooxygenase Activity Tyrosine Biosynthetic Process, By Oxidation Of Phenylalanine Maintenance Of Protein Localization At Cell Tip Transmembrane Transporter Binding Innate Immune Response Phosphothreonine Residue Binding Linear Polyubiquitin Binding Nuclear Receptor-mediated Glucocorticoid Signaling Pathway Phosphoserine Residue Binding Defense Response To Other Organism Nuclear Receptor-mediated Corticosteroid Signaling Pathway Beta-2 Adrenergic Receptor Binding Regulation Of Macroautophagy Negative Regulation Of Potassium Ion Export Across Plasma Membrane Defense Response To Symbiont Maintenance Of Animal Organ Identity Bundle Of His Cell-Purkinje Myocyte Adhesion Involved In Cell Communication Intermediate Filament Binding Cell Adhesive Protein Binding Involved In Bundle Of His Cell-Purkinje Myocyte Communication Nucleus Sodium Channel Inhibitor Activity Protein Domain Specific Binding Tetrahydrobiopterin Biosynthetic Process Cell Tip Cardiac Muscle Cell-cardiac Muscle Cell Adhesion Intermediate Filament Bundle Assembly Desmosome Assembly IkappaB Kinase Complex Tetrahydrobiopterin Metabolic Process Potassium Channel Inhibitor Activity Alpha-catenin Binding Negative Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Potassium Ion Export Across Plasma Membrane Progesterone Receptor Signaling Pathway Regulation Of Ventricular Cardiac Muscle Cell Action Potential Transferrin Receptor Binding Anoikis Endocardial Cushion Development Response To Other Organism Negative Regulation Of Sodium Ion Transport Pteridine-containing Compound Biosynthetic Process Desmosome Organization	TRNA Transcription By RNA Polymerase III TRNA Transcription RNA Polymerase III Complex Transcription By RNA Polymerase III DNA-directed RNA Polymerase Complex Positive Regulation Of Interferon-beta Production Regulation Of Interferon-beta Production Positive Regulation Of Type I Interferon Production Regulation Of Type I Interferon Production TRNA Metabolic Process Defense Response To Virus Response To Virus DNA-templated Transcription DNA/RNA Hybrid Binding Positive Regulation Of Cytokine Production Chromatin Binding 5'-3' RNA Polymerase Activity Innate Immune Response Defense Response To Other Organism Defense Response To Symbiont Regulation Of Cytokine Production Nucleobase-containing Compound Biosynthetic Process DNA-directed RNA Polymerase Activity Response To Other Organism Immune Response Positive Regulation Of Gene Expression Response To External Biotic Stimulus Defense Response RNA Metabolic Process Macromolecule Biosynthetic Process Positive Regulation Of Multicellular Organismal Process Nucleotidyltransferase Activity Immune System Process Nucleic Acid Metabolic Process DNA Binding Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Magnesium Ion Binding
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