POLR3A and POLR3E

Number of citations of the paper that reports this interaction (PMID 12391170)
22

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, biochemical)
HPRD (in vitro, in vivo)

		POLR3A	POLR3E
Gene Name		polymerase (RNA) III (DNA directed) polypeptide A, 155kDa	polymerase (RNA) III (DNA directed) polypeptide E (80kD)
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm DNA-directed RNA Polymerase III Complex Cytosol Membrane	Nucleus Nucleoplasm DNA-directed RNA Polymerase III Complex Centrosome Cytosol
	Molecular Function	RNA Polymerase III Activity DNA Binding Chromatin Binding DNA-directed RNA Polymerase Activity Zinc Ion Binding Ribonucleoside Binding	RNA Polymerase III Activity
	Biological Process	Transcription, DNA-templated Transcription From RNA Polymerase III Promoter Transcription Elongation From RNA Polymerase III Promoter Termination Of RNA Polymerase III Transcription Gene Expression Positive Regulation Of Type I Interferon Production Positive Regulation Of Interferon-beta Production Innate Immune Response Defense Response To Virus	Transcription From RNA Polymerase III Promoter Transcription Elongation From RNA Polymerase III Promoter Termination Of RNA Polymerase III Transcription Gene Expression Positive Regulation Of Type I Interferon Production Innate Immune Response Defense Response To Virus
Pathways		RNA Polymerase III Transcription Termination RNA Polymerase III Transcription RNA Polymerase III Transcription Initiation RNA Polymerase III Transcription Initiation From Type 3 Promoter RNA Polymerase III Transcription Initiation From Type 1 Promoter RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription RNA Polymerase III Abortive And Retractive Initiation Cytosolic sensors of pathogen-associated DNA RNA Polymerase III Chain Elongation RNA Polymerase III Transcription Initiation From Type 2 Promoter Innate Immune System	RNA Polymerase III Transcription Termination RNA Polymerase III Transcription RNA Polymerase III Transcription Initiation RNA Polymerase III Transcription Initiation From Type 3 Promoter RNA Polymerase III Transcription Initiation From Type 1 Promoter RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription RNA Polymerase III Abortive And Retractive Initiation Cytosolic sensors of pathogen-associated DNA RNA Polymerase III Chain Elongation RNA Polymerase III Transcription Initiation From Type 2 Promoter Innate Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		6 interactors: EWSR1 IKBKG NEDD4 PCBD1 PKP2 POLR3E	2 interactors: POLR3A POLR3D
Entrez ID		11128	55718
HPRD ID		17879	15155
Ensembl ID		ENSG00000148606	ENSG00000058600
Uniprot IDs		O14802	Q9NVU0
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Sodium Ion Transport Positive Regulation Of Type I Interferon Production Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To UV-induced DNA Damage Transmission Of Virus Development Involved In Symbiotic Interaction Regulation Of Type I Interferon Production Adherens Junction Maintenance Intracellular Receptor Signaling Pathway Transcription, DNA-templated Maintenance Of Organ Identity Heart Morphogenesis RNA Biosynthetic Process Intermediate Filament Bundle Assembly Progesterone Receptor Signaling Pathway Regulation Of Transcription From RNA Polymerase II Promoter In Response To UV-induced DNA Damage Response To Virus Bundle Of His Cell To Purkinje Myocyte Communication Regulation Of Membrane Potential Glucocorticoid Receptor Signaling Pathway Desmosome Assembly Tetrahydrobiopterin Biosynthetic Process Regulation Of Tight Junction Assembly Immune Response Protein Targeting To Lysosome Cell Communication By Electrical Coupling Involved In Cardiac Conduction L-phenylalanine Catabolic Process Negative Regulation Of Sodium Ion Transport Negative Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Desmosome Organization Positive Regulation Of Cytokine Production L-phenylalanine Metabolic Process Protein Localization To Lysosome Cell Communication By Electrical Coupling RNA Metabolic Process Termination Of RNA Polymerase III Transcription Transcription Elongation From RNA Polymerase III Promoter Cell-cell Signaling Involved In Cardiac Conduction Intermediate Filament Organization Regulation Of Protein Homodimerization Activity Receptor Catabolic Process Ventricular Cardiac Muscle Cell Action Potential Gene Expression Protein Targeting To Vacuole Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Heart Rate By Cardiac Conduction Cellular Macromolecule Biosynthetic Process Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Gap Junction Assembly Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Establishment Of Protein Localization To Vacuole	Termination Of RNA Polymerase III Transcription Transcription Elongation From RNA Polymerase III Promoter Positive Regulation Of Interferon-beta Production Regulation Of Interferon-beta Production Transcription From RNA Polymerase III Promoter DNA-templated Transcription, Termination Positive Regulation Of Type I Interferon Production DNA-templated Transcription, Elongation Regulation Of Type I Interferon Production Defense Response To Virus Response To Virus Positive Regulation Of Cytokine Production Regulation Of Cytokine Production Response To Other Organism Response To Biotic Stimulus Innate Immune Response Immune Response Defense Response Response To External Stimulus Immune System Process Transcription, DNA-templated RNA Biosynthetic Process Positive Regulation Of Innate Immune Response RNA Metabolic Process Regulation Of Innate Immune Response Response To Stress Gene Expression Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process
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