POLR3A and EWSR1

Number of citations of the paper that reports this interaction (PMID 20211142)
148

Data Source:
BioGRID (two hybrid)

		POLR3A	EWSR1
Gene Name		polymerase (RNA) III (DNA directed) polypeptide A, 155kDa	EWS RNA-binding protein 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm DNA-directed RNA Polymerase III Complex Cytosol Membrane	Nucleus Nucleoplasm Nucleolus Cytoplasm Plasma Membrane
	Molecular Function	RNA Polymerase III Activity DNA Binding Chromatin Binding DNA-directed RNA Polymerase Activity Zinc Ion Binding Ribonucleoside Binding	Nucleotide Binding RNA Binding Protein Binding Calmodulin Binding Zinc Ion Binding Identical Protein Binding Poly(A) RNA Binding
	Biological Process	Transcription, DNA-templated Transcription From RNA Polymerase III Promoter Transcription Elongation From RNA Polymerase III Promoter Termination Of RNA Polymerase III Transcription Gene Expression Positive Regulation Of Type I Interferon Production Positive Regulation Of Interferon-beta Production Innate Immune Response Defense Response To Virus	Transcription, DNA-templated Regulation Of Transcription, DNA-templated
Pathways		RNA Polymerase III Transcription Termination RNA Polymerase III Transcription RNA Polymerase III Transcription Initiation RNA Polymerase III Transcription Initiation From Type 3 Promoter RNA Polymerase III Transcription Initiation From Type 1 Promoter RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription RNA Polymerase III Abortive And Retractive Initiation Cytosolic sensors of pathogen-associated DNA RNA Polymerase III Chain Elongation RNA Polymerase III Transcription Initiation From Type 2 Promoter Innate Immune System
Drugs
Diseases
GWAS			Breast cancer ( 23535729)
Protein-Protein Interactions		6 interactors: EWSR1 IKBKG NEDD4 PCBD1 PKP2 POLR3E	159 interactors: ACTL6A AGT ATN1 ATPAF2 ATXN3 BAD BARD1 BLZF1 BNIP3L BTK C10orf12 C11orf16 C19orf57 CALM1 CCDC91 CD177 CDK12 CEACAM5 CETP CFDP1 CHERP CNST CPSF6 CPSF7 CREBBP CUEDC2 CXADR DFFA DHX9 DMRTB1 DNAJB3 DYNLL2 E2F8 ECD ELAVL3 ELAVL4 ELK1 EP300 EPAS1 EPT1 ERCC5 FAM131C FASN FLI1 FUS FXR2 GNPDA1 GPBP1L1 HBP1 HDAC3 HERPUD1 HIST1H2BN HLTF HMGA1 HMGN4 HNRNPUL1 HSPA2 IRF3 ITCH ITGB5 JUN KCNMB1 KEL KHDRBS2 KRR1 KXD1 LILRA3 MAGEA11 MAPK1IP1L MATK MDFI MNS1 MRPS18B MSC MTCP1 MTMR9 MVK MYL6 MYO1F MYOZ2 NBPF3 NDRG1 NDUFB1 NDUFV1 NINL NLE1 NONO NPPB NSUN4 NTNG2 PCBP1 PDHX PEF1 PGLS PLSCR1 POLR2G POLR3A POU4F1 POU5F1 PRKCA PRMT1 PRR13 PRRC2A PRTFDC1 PRUNE2 PTK2B RAB37 RAD23A RALYL RASL11B RBPMS RFX3 RHOXF2 RMND5B RNF183 RPL31 RPS15A SALL2 SCMH1 SEC24A SEC24D SERP2 SF1 SF3B4 SLC1A1 SLC22A24 SMAD1 SMAD4 SNRPC SSBP2 SSBP3 SUPT4H1 SUV39H2 TAF1 TFG TMSB4Y TONSL TPGS2 TRAF1 TRAF2 TRAF3 TRIM37 TRIM5 TRPV5 TSPAN3 TULP2 USP7 VPS72 WBP4 WDR37 WWP1 WWP2 YWHAG YY1AP1 ZBTB1 ZDHHC3 ZNF165 ZNF184 ZNF383
Entrez ID		11128	2130
HPRD ID		17879	00592
Ensembl ID		ENSG00000148606	ENSG00000182944
Uniprot IDs		O14802	Q01844
PDB IDs			2CPE
Enriched GO Terms of Interacting Partners?		Regulation Of Sodium Ion Transport Positive Regulation Of Type I Interferon Production Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To UV-induced DNA Damage Transmission Of Virus Development Involved In Symbiotic Interaction Regulation Of Type I Interferon Production Adherens Junction Maintenance Intracellular Receptor Signaling Pathway Transcription, DNA-templated Maintenance Of Organ Identity Heart Morphogenesis RNA Biosynthetic Process Intermediate Filament Bundle Assembly Progesterone Receptor Signaling Pathway Regulation Of Transcription From RNA Polymerase II Promoter In Response To UV-induced DNA Damage Response To Virus Bundle Of His Cell To Purkinje Myocyte Communication Regulation Of Membrane Potential Glucocorticoid Receptor Signaling Pathway Desmosome Assembly Tetrahydrobiopterin Biosynthetic Process Regulation Of Tight Junction Assembly Immune Response Protein Targeting To Lysosome Cell Communication By Electrical Coupling Involved In Cardiac Conduction L-phenylalanine Catabolic Process Negative Regulation Of Sodium Ion Transport Negative Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Desmosome Organization Positive Regulation Of Cytokine Production L-phenylalanine Metabolic Process Protein Localization To Lysosome Cell Communication By Electrical Coupling RNA Metabolic Process Termination Of RNA Polymerase III Transcription Transcription Elongation From RNA Polymerase III Promoter Cell-cell Signaling Involved In Cardiac Conduction Intermediate Filament Organization Regulation Of Protein Homodimerization Activity Receptor Catabolic Process Ventricular Cardiac Muscle Cell Action Potential Gene Expression Protein Targeting To Vacuole Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Heart Rate By Cardiac Conduction Cellular Macromolecule Biosynthetic Process Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Gap Junction Assembly Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Establishment Of Protein Localization To Vacuole	RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Gene Expression Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process RNA Biosynthetic Process Nitrogen Compound Metabolic Process Transcription, DNA-templated Regulation Of Nitrogen Compound Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Gene Expression Regulation Of RNA Biosynthetic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of Transcription, DNA-templated Cellular Macromolecule Biosynthetic Process Cellular Metabolic Process Macromolecule Biosynthetic Process Regulation Of Metabolic Process Negative Regulation Of Cellular Metabolic Process Response To Stress Viral Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Biosynthetic Process Negative Regulation Of Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter RNA Processing Negative Regulation Of Gene Expression Cellular Response To Stress Regulation Of Establishment Of Protein Localization Negative Regulation Of Transcription, DNA-templated MRNA Metabolic Process MRNA Processing Apoptotic Process Regulation Of Intracellular Transport Response To Virus Programmed Cell Death Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Cellular Localization Regulation Of Cellular Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Protein Transport Immune System Process Regulation Of Protein Localization Cell Death Defense Response Death Regulation Of Cell Death
Tagcloud ?			arranged blue cauda cd99 cords equina focal fusion glomus hybridization immunophenotypic indolent infrequent involving ki labeling longstanding mitoses nerve nests neu reverse roots rosette round smooth spinal transcriptase wt1
Tagcloud (Difference) ?			arranged blue cauda cd99 cords equina focal fusion glomus hybridization immunophenotypic indolent infrequent involving ki labeling longstanding mitoses nerve nests neu reverse roots rosette round smooth spinal transcriptase wt1
Tagcloud (Intersection) ?