SHANK2 and RHOT1

		SHANK2	RHOT1
Description		SH3 and multiple ankyrin repeat domains 2	ras homolog family member T1
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GO Annotations	Cellular Component	Photoreceptor Outer Segment Photoreceptor Inner Segment Cytoplasm Cytosol Neurofilament Plasma Membrane Postsynaptic Density Membrane Apical Plasma Membrane Growth Cone Brush Border Membrane Cell Projection Neuron Projection Neuronal Cell Body Dendritic Spine Synapse Postsynaptic Membrane Ciliary Membrane	Mitochondrion Mitochondrial Outer Membrane Membrane
	Molecular Function	Protein Binding SH3 Domain Binding Synaptic Receptor Adaptor Activity Ionotropic Glutamate Receptor Binding	Nucleotide Binding Magnesium Ion Binding GTPase Activity Calcium Ion Binding Protein Binding GTP Binding Hydrolase Activity ATP Hydrolysis Activity GDP Binding Metal Ion Binding
	Biological Process	Synapse Assembly Learning Positive Regulation Of Cell Population Proliferation Associative Learning Adult Behavior Social Behavior Negative Regulation Of Hippo Signaling Synapse Organization Cognition Long-term Synaptic Potentiation Long-term Synaptic Depression Vocalization Behavior	Mitochondrion Organization Regulation Of Mitochondrion Organization Cellular Homeostasis Mitochondrion Transport Along Microtubule Mitochondrial Outer Membrane Permeabilization
Pathways		Neurexins and neuroligins Neurexins and neuroligins	Ub-specific processing proteases RHOT1 GTPase cycle RHOT1 GTPase cycle
Drugs
Diseases
GWAS		Bipolar disorder ( 31043756 34002096) Eosinophilic esophagitis ( 34506852) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Hip circumference ( 28552196) Hodgkin's lymphoma ( 34216518) Kawasaki disease ( 33692975) Late-onset Alzheimer's disease ( 27770636) Obesity-related traits ( 23251661) Response to fenofibrate (adiponectin levels) ( 23149075) Urate levels in obese individuals ( 25811787)	Cataracts ( 34127677) High chromosomal aberration frequency (chromosome type) ( 31586183) High chromosomal aberration frequency (chromosome type) in genotoxic compound exposure ( 31586183) Obesity-related traits ( 23251661)
Interacting Genes		21 interacting genes: ACE2 ADGRB2 ADGRL1 ADGRL2 AKT1 ARHGAP12 ARHGEF7 BAIAP2 CTTN DLG4 DLGAP1 DLGAP2 DLGAP3 DLGAP4 DNM2 HOMER1 PPP3CA RIPOR3 SHARPIN SLC9A3 SSTR2
Entrez ID		22941	55288
HPRD ID		04479	15247
Ensembl ID		ENSG00000162105	ENSG00000126858
Uniprot IDs		A0A590UJ45 A6NHU9 Q9UPX8	H7BXZ6 Q8IXI2
PDB IDs		8ATJ 8B10	5KSO 5KSP 5KSY 5KSZ 5KTY 5KU1 6D71
Enriched GO Terms of Interacting Partners?		Synapse Glutamatergic Synapse Postsynaptic Specialization Postsynapse Postsynaptic Density Neuron Projection Modulation Of Chemical Synaptic Transmission Vesicle Scission Latrotoxin Receptor Activity Modification Of Postsynaptic Structure Dendritic Spine Modification Of Synaptic Structure Plasma Membrane Cell Projection Morphogenesis Cell Projection PDZ Domain Binding Regulation Of Synapse Organization Regulation Of Cellular Component Organization Membrane Organization Synaptic Vesicle Budding From Presynaptic Endocytic Zone Membrane Regulation Of Cell Projection Organization Membrane Presynapse Cellular Response To Peptide Neuron Spine Synapse Organization Neuron Projection Morphogenesis Regulation Of Postsynapse Organization Regulation Of Nervous System Development Cell Projection Organization Cholinergic Synapse Cell Junction Organization Protein Localization To Membrane Receptor-mediated Endocytosis Clathrin-coated Pit Negative Regulation Of Cellular Component Organization Cell Cortex Signal Transduction Endocytic Vesicle Membrane Negative Regulation Of CGAS/STING Signaling Pathway Positive Regulation Of Fibroblast Migration Molecular Adaptor Activity Lamellipodium Neuromuscular Junction Proline-rich Region Binding Intracellular Protein Transport Neuron Projection Terminus Calcineurin-NFAT Signaling Cascade G Protein-coupled Receptor Signaling Pathway Schaffer Collateral - CA1 Synapse	Synaptic Receptor Adaptor Activity Long-term Synaptic Depression Social Behavior Regulation Of Hippo Signaling Photoreceptor Inner Segment Ciliary Membrane Negative Regulation Of Hippo Signaling Long-term Synaptic Potentiation Negative Regulation Of Synaptic Transmission Vocalization Behavior Ionotropic Glutamate Receptor Binding Neurofilament Brush Border Membrane Photoreceptor Outer Segment Associative Learning Synapse Assembly SH3 Domain Binding Dendritic Spine Positive Regulation Of Synaptic Transmission Adult Behavior Growth Cone Learning Regulation Of Synaptic Plasticity Postsynaptic Membrane Cell Junction Assembly Postsynaptic Density Learning Or Memory Synapse Organization Cognition Neuron Projection Apical Plasma Membrane Neuronal Cell Body
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