SHANK2 and ARHGAP12

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SHANK2	ARHGAP12
Description		SH3 and multiple ankyrin repeat domains 2	Rho GTPase activating protein 12
Image			No pdb structure
GO Annotations	Cellular Component	Photoreceptor Outer Segment Photoreceptor Inner Segment Cytoplasm Cytosol Neurofilament Plasma Membrane Postsynaptic Density Membrane Apical Plasma Membrane Growth Cone Brush Border Membrane Cell Projection Neuron Projection Neuronal Cell Body Dendritic Spine Synapse Postsynaptic Membrane Ciliary Membrane	Phagocytic Cup Cytoplasm Plasma Membrane Postsynapse Glutamatergic Synapse
	Molecular Function	Protein Binding SH3 Domain Binding Synaptic Receptor Adaptor Activity Ionotropic Glutamate Receptor Binding	GTPase Activator Activity Protein Binding
	Biological Process	Synapse Assembly Learning Positive Regulation Of Cell Population Proliferation Associative Learning Adult Behavior Social Behavior Negative Regulation Of Hippo Signaling Synapse Organization Cognition Long-term Synaptic Potentiation Long-term Synaptic Depression Vocalization Behavior	Morphogenesis Of An Epithelial Sheet Phagocytosis, Engulfment Actin Filament Organization Signal Transduction Small GTPase-mediated Signal Transduction Negative Regulation Of Small GTPase Mediated Signal Transduction Regulation Of Postsynapse Assembly
Pathways		Neurexins and neuroligins Neurexins and neuroligins	RAC1 GTPase cycle RHOD GTPase cycle RHOV GTPase cycle RHOF GTPase cycle
Drugs
Diseases
GWAS		Bipolar disorder ( 31043756 34002096) Eosinophilic esophagitis ( 34506852) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Hip circumference ( 28552196) Hodgkin's lymphoma ( 34216518) Kawasaki disease ( 33692975) Late-onset Alzheimer's disease ( 27770636) Obesity-related traits ( 23251661) Response to fenofibrate (adiponectin levels) ( 23149075) Urate levels in obese individuals ( 25811787)	C-reactive protein levels ( 24763700) Glycine levels ( 30837465) Intraocular pressure ( 31959993) Pulse pressure ( 27841878 28135244) Systolic blood pressure ( 27841878) Uterine fibroids ( 31649266)
Interacting Genes		21 interacting genes: ACE2 ADGRB2 ADGRL1 ADGRL2 AKT1 ARHGAP12 ARHGEF7 BAIAP2 CTTN DLG4 DLGAP1 DLGAP2 DLGAP3 DLGAP4 DNM2 HOMER1 PPP3CA RIPOR3 SHARPIN SLC9A3 SSTR2	5 interacting genes: RAC1 SHANK2 SRPK1 SRPK2 TRIP10
Entrez ID		22941	94134
HPRD ID		04479	06446
Ensembl ID		ENSG00000162105	ENSG00000165322
Uniprot IDs		A0A590UJ45 A6NHU9 Q9UPX8	Q1RLN5 Q8IWW6
PDB IDs		8ATJ 8B10
Enriched GO Terms of Interacting Partners?		Synapse Glutamatergic Synapse Postsynaptic Specialization Postsynapse Postsynaptic Density Neuron Projection Modulation Of Chemical Synaptic Transmission Vesicle Scission Latrotoxin Receptor Activity Modification Of Postsynaptic Structure Dendritic Spine Modification Of Synaptic Structure Plasma Membrane Cell Projection Morphogenesis Cell Projection PDZ Domain Binding Regulation Of Synapse Organization Regulation Of Cellular Component Organization Membrane Organization Synaptic Vesicle Budding From Presynaptic Endocytic Zone Membrane Regulation Of Cell Projection Organization Membrane Presynapse Cellular Response To Peptide Neuron Spine Synapse Organization Neuron Projection Morphogenesis Regulation Of Postsynapse Organization Regulation Of Nervous System Development Cell Projection Organization Cholinergic Synapse Cell Junction Organization Protein Localization To Membrane Receptor-mediated Endocytosis Clathrin-coated Pit Negative Regulation Of Cellular Component Organization Cell Cortex Signal Transduction Endocytic Vesicle Membrane Negative Regulation Of CGAS/STING Signaling Pathway Positive Regulation Of Fibroblast Migration Molecular Adaptor Activity Lamellipodium Neuromuscular Junction Proline-rich Region Binding Intracellular Protein Transport Neuron Projection Terminus Calcineurin-NFAT Signaling Cascade G Protein-coupled Receptor Signaling Pathway Schaffer Collateral - CA1 Synapse	Phagocytic Cup Positive Regulation Of Viral Genome Replication Spliceosomal Complex Assembly Negative Regulation Of Viral Genome Replication Positive Regulation Of Viral Process Interleukin-2 Receptor Complex Defense Response Positive Regulation Of Ovarian Follicle Development Negative Regulation Of Interleukin-23 Production Regulation Of ERK5 Cascade Angiotensin-activated Signaling Pathway Involved In Heart Process Embryonic Olfactory Bulb Interneuron Precursor Migration Cerebral Cortex GABAergic Interneuron Development Regulation Of Viral Genome Replication Regulation Of Viral Life Cycle Negative Regulation Of Viral Process Regulation Of MRNA Splicing, Via Spliceosome Regulation Of T Cell Homeostatic Proliferation Interleukin-2 Binding Interleukin-2 Receptor Activity Rho GDP-dissociation Inhibitor Binding Regulation Of Cell Adhesion Involved In Heart Morphogenesis Regulation Of MRNA Processing Regulation Of Viral Process Nuclear Speck Organization Synaptic Receptor Adaptor Activity Homeostasis Of Number Of Cells Regulation Of Ovarian Follicle Development Cell Cortex Erythrocyte Enucleation Regulation Of RNA Splicing Regulation Of Synaptic Plasticity Auditory Receptor Cell Morphogenesis Engulfment Of Apoptotic Cell Tangential Migration From The Subventricular Zone To The Olfactory Bulb Protein-RNA Complex Assembly Magnesium Ion Binding Positive Regulation Of Cell Population Proliferation Activation-induced Cell Death Of T Cells Kinocilium G Protein-coupled Receptor Signaling Pathway Involved In Heart Process Positive Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering Postsynaptic Membrane Hepatocyte Growth Factor Receptor Signaling Pathway Activated T Cell Proliferation Regulation Of Neuron Maturation Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering R-loop Processing Positive Regulation Of Bicellular Tight Junction Assembly Regulation Of Interleukin-23 Production
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