SHANK2 and PPP3CA

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SHANK2	PPP3CA
Description		SH3 and multiple ankyrin repeat domains 2	protein phosphatase 3 catalytic subunit alpha
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GO Annotations	Cellular Component	Photoreceptor Outer Segment Photoreceptor Inner Segment Cytoplasm Cytosol Neurofilament Plasma Membrane Postsynaptic Density Membrane Apical Plasma Membrane Growth Cone Brush Border Membrane Cell Projection Neuron Projection Neuronal Cell Body Dendritic Spine Synapse Postsynaptic Membrane Ciliary Membrane	Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol Plasma Membrane Calcineurin Complex Protein Serine/threonine Phosphatase Complex Cytoplasmic Side Of Plasma Membrane Membrane Extrinsic Component Of Plasma Membrane Z Disc Sarcolemma Cell Projection Dendritic Spine Synapse Schaffer Collateral - CA1 Synapse Glutamatergic Synapse
	Molecular Function	Protein Binding SH3 Domain Binding Synaptic Receptor Adaptor Activity Ionotropic Glutamate Receptor Binding	Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity Calcium Ion Binding Protein Binding Calmodulin Binding Hydrolase Activity Enzyme Binding Calmodulin-dependent Protein Phosphatase Activity Metal Ion Binding Protein Dimerization Activity ATPase Binding
	Biological Process	Synapse Assembly Learning Positive Regulation Of Cell Population Proliferation Associative Learning Adult Behavior Social Behavior Negative Regulation Of Hippo Signaling Synapse Organization Cognition Long-term Synaptic Potentiation Long-term Synaptic Depression Vocalization Behavior	G1/S Transition Of Mitotic Cell Cycle Protein Dephosphorylation Protein Import Into Nucleus Calcium Ion Transport Epidermis Development Positive Regulation Of Cardiac Muscle Hypertrophy Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Transition Between Fast And Slow Fiber Cardiac Muscle Hypertrophy In Response To Stress Dephosphorylation Calcium-mediated Signaling Negative Regulation Of Signaling Keratinocyte Differentiation Positive Regulation Of Cell Migration Calcineurin-NFAT Signaling Cascade Multicellular Organismal Response To Stress Wound Healing Positive Regulation Of Activated T Cell Proliferation T Cell Activation Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Skeletal Muscle Tissue Regeneration Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Osteoclast Differentiation Positive Regulation Of Cell Adhesion Positive Regulation Of Endocytosis Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Saliva Secretion Skeletal Muscle Fiber Development Dendrite Morphogenesis Negative Regulation Of Dendrite Morphogenesis Modulation Of Chemical Synaptic Transmission Response To Calcium Ion Excitatory Postsynaptic Potential Regulation Of Cell Proliferation Involved In Kidney Morphogenesis Peptidyl-serine Dephosphorylation Renal Sodium Ion Absorption Positive Regulation Of Calcineurin-NFAT Signaling Cascade Positive Regulation Of Glomerulus Development Renal Filtration Calcineurin-mediated Signaling Postsynaptic Modulation Of Chemical Synaptic Transmission Negative Regulation Of Angiotensin-activated Signaling Pathway Positive Regulation Of Angiotensin-activated Signaling Pathway Positive Regulation Of Calcium Ion-dependent Exocytosis Of Neurotransmitter Positive Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Positive Regulation Of Connective Tissue Replacement Positive Regulation Of Calcium Ion Import Across Plasma Membrane Negative Regulation Of Calcium Ion Import Across Plasma Membrane
Pathways		Neurexins and neuroligins Neurexins and neuroligins	DARPP-32 events Calcineurin activates NFAT Calcineurin activates NFAT FCERI mediated Ca+2 mobilization Ca2+ pathway CLEC7A (Dectin-1) induces NFAT activation
Drugs			Myristic acid
Diseases
GWAS		Bipolar disorder ( 31043756 34002096) Eosinophilic esophagitis ( 34506852) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Hip circumference ( 28552196) Hodgkin's lymphoma ( 34216518) Kawasaki disease ( 33692975) Late-onset Alzheimer's disease ( 27770636) Obesity-related traits ( 23251661) Response to fenofibrate (adiponectin levels) ( 23149075) Urate levels in obese individuals ( 25811787)	Adult body size ( 32376654) Anorexia nervosa ( 24514567) Bitter non-alcoholic beverage consumption ( 31046077) Blood pressure ( 22763476) Chronotype ( 30696823) Corneal structure ( 21979947) Trunk fat mass ( 28552196) Vitiligo ( 27723757)
Interacting Genes		21 interacting genes: ACE2 ADGRB2 ADGRL1 ADGRL2 AKT1 ARHGAP12 ARHGEF7 BAIAP2 CTTN DLG4 DLGAP1 DLGAP2 DLGAP3 DLGAP4 DNM2 HOMER1 PPP3CA RIPOR3 SHARPIN SLC9A3 SSTR2	44 interacting genes: AATK ABI2 AKAP5 AMPH ATP2B4 BAD BCL2 BTG3 C16orf74 CABIN1 CASP3 CEBPA CRTC2 DCPH1 FAM167A FGFR4 FKBP1A FKBP8 GABRA1 GABRB2 GABRG2 GRB2 ITPKB KCNIP3 KLHL3 MARCHF7 MYOZ2 MYOZ3 OGT PLAC8 PPP3R1 PRKCZ PTK7 RCAN1 RCAN2 RYK SHANK2 SNCA SOD1 STUB1 SYNJ1 UBC UBE4B UNC119
Entrez ID		22941	5530
HPRD ID		04479	00234
Ensembl ID		ENSG00000162105	ENSG00000138814
Uniprot IDs		A0A590UJ45 A6NHU9 Q9UPX8	A0A0S2Z4B5 A0A0S2Z4C6 Q08209
PDB IDs		8ATJ 8B10	1AUI 1M63 1MF8 2JOG 2JZI 2P6B 2R28 2W73 3LL8 4F0Z 4Q5U 5C1V 5SVE 6NUC 6NUF 6NUU 6UUQ 9B9G
Enriched GO Terms of Interacting Partners?		Synapse Glutamatergic Synapse Postsynaptic Specialization Postsynapse Postsynaptic Density Neuron Projection Modulation Of Chemical Synaptic Transmission Vesicle Scission Latrotoxin Receptor Activity Modification Of Postsynaptic Structure Dendritic Spine Modification Of Synaptic Structure Plasma Membrane Cell Projection Morphogenesis Cell Projection PDZ Domain Binding Regulation Of Synapse Organization Regulation Of Cellular Component Organization Membrane Organization Synaptic Vesicle Budding From Presynaptic Endocytic Zone Membrane Regulation Of Cell Projection Organization Membrane Presynapse Cellular Response To Peptide Neuron Spine Synapse Organization Neuron Projection Morphogenesis Regulation Of Postsynapse Organization Regulation Of Nervous System Development Cell Projection Organization Cholinergic Synapse Cell Junction Organization Protein Localization To Membrane Receptor-mediated Endocytosis Clathrin-coated Pit Negative Regulation Of Cellular Component Organization Cell Cortex Signal Transduction Endocytic Vesicle Membrane Negative Regulation Of CGAS/STING Signaling Pathway Positive Regulation Of Fibroblast Migration Molecular Adaptor Activity Lamellipodium Neuromuscular Junction Proline-rich Region Binding Intracellular Protein Transport Neuron Projection Terminus Calcineurin-NFAT Signaling Cascade G Protein-coupled Receptor Signaling Pathway Schaffer Collateral - CA1 Synapse	Protein Phosphatase 2B Binding Regulation Of Calcineurin-mediated Signaling Regulation Of Calcineurin-NFAT Signaling Cascade Intracellular Signal Transduction Calcium-dependent Protein Serine/threonine Phosphatase Regulator Activity Calcineurin-NFAT Signaling Cascade Regulation Of Signal Transduction Calcineurin-mediated Signaling Regulation Of Intracellular Signal Transduction Intracellular Signaling Cassette Regulation Of Metal Ion Transport Cell Junction Organization Dendritic Spine Regulation Of Cell Communication Regulation Of Signaling Synapse Organization Regulation Of Calcium-mediated Signaling Regulation Of Monoatomic Cation Transmembrane Transport Regulation Of Cell Activation Cell Junction Assembly Calcium-mediated Signaling BAD-BCL-2 Complex Synapse Assembly Negative Regulation Of Calcineurin-NFAT Signaling Cascade GABA-gated Chloride Ion Channel Activity Regulation Of Monoatomic Ion Transmembrane Transport Signal Transduction Chemical Homeostasis Regulation Of Monoatomic Ion Transport Tissue Morphogenesis GABA-A Receptor Activity GABA-A Receptor Complex Chemical Synaptic Transmission Regulation Of Membrane Potential Homeostatic Process Negative Regulation Of Calcium-mediated Signaling Response To Metal Ion Trans-synaptic Signaling Z Disc Regulation Of Calcium Ion Transport Positive Regulation Of Cell Communication Positive Regulation Of Signaling Inhibitory Synapse Assembly Synaptic Signaling Regulation Of Calcium Ion Transmembrane Transport Response To Oxidative Stress Gamma-aminobutyric Acid Signaling Pathway Regulation Of Lymphocyte Activation Postsynaptic Specialization Membrane Negative Regulation Of Apoptotic Process
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