SHANK2 and LPHN1

Number of citations of the paper that reports this interaction (PMID 10964907)
14

Data Source:
HPRD (in vivo, two hybrid, in vitro)

		SHANK2	LPHN1
Gene Name		SH3 and multiple ankyrin repeat domains 2	latrophilin 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Photoreceptor Outer Segment Photoreceptor Inner Segment Cellular_component Neurofilament Plasma Membrane Ionotropic Glutamate Receptor Complex Postsynaptic Density Apical Plasma Membrane Cell Junction Growth Cone Brush Border Membrane Neuron Projection Neuronal Cell Body Dendritic Spine Postsynaptic Membrane Ciliary Membrane	Plasma Membrane Integral Component Of Membrane Cell Junction Axon Growth Cone Presynaptic Membrane Neuron Projection Synapse
	Molecular Function	Protein Binding SH3 Domain Binding GKAP/Homer Scaffold Activity Ionotropic Glutamate Receptor Binding	G-protein Coupled Receptor Activity Protein Binding Latrotoxin Receptor Activity Carbohydrate Binding Cell Adhesion Molecule Binding
	Biological Process	Synapse Assembly Learning Memory Adult Behavior Social Behavior Exploration Behavior Long-term Synaptic Potentiation Long Term Synaptic Depression Vocalization Behavior	Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules G-protein Coupled Receptor Signaling Pathway Calcium-mediated Signaling Using Intracellular Calcium Source Positive Regulation Of Synapse Maturation
Pathways
Drugs
Diseases
GWAS		Obesity-related traits ( 23251661) Response to fenofibrate (adiponectin levels) ( 23149075)	Mortality among heart failure patients ( 20400778)
Protein-Protein Interactions		15 interactors: ARHGEF7 BAI2 BAIAP2 CTTN DLG4 DLGAP1 DLGAP2 DLGAP3 DLGAP4 DNM2 LPHN1 LPHN2 SHARPIN SLC9A3 SSTR2	9 interactors: ANKS1A APC CACNA1A DLG3 DLG4 PSMA3 ROS1 SHANK1 SHANK2
Entrez ID		22941	22859
HPRD ID		04479	14305
Ensembl ID		ENSG00000162105
Uniprot IDs		C0SPH0 Q9UPX8	O94910
PDB IDs
Enriched GO Terms of Interacting Partners?		Cell-cell Signaling Signaling Cell Communication Synaptic Transmission Nervous System Development Neuron Projection Morphogenesis Dendritic Spine Organization Neuron Projection Development Cell Projection Morphogenesis Cell Part Morphogenesis Regulation Of Cell Morphogenesis Focal Adhesion Assembly Neuron Development Cell Morphogenesis Adherens Junction Assembly Lamellipodium Organization Neuron Differentiation Cell-substrate Junction Assembly Cell Projection Organization Endocytosis Regulation Of Cellular Component Organization Regulation Of Axon Extension Negative Regulation Of Membrane Tubulation Post-Golgi Vesicle-mediated Transport Adherens Junction Organization System Development Regulation Of CD40 Signaling Pathway Protein Linear Polyubiquitination Positive Regulation Of Lamellipodium Morphogenesis Generation Of Neurons Synaptic Vesicle Transport Neurogenesis Somatostatin Signaling Pathway Regulation Of Cell Size Regulation Of Cell Projection Organization Dendrite Development Alpha-amino-3-hydroxy-5-methyl-4-isoxazole Propionate Selective Glutamate Receptor Clustering Regulation Of Grooming Behavior Cell Development Multicellular Organismal Development Axonogenesis Maintenance Of Apical/basal Cell Polarity Regulation Of Lamellipodium Morphogenesis Regulation Of Axonogenesis Regulation Of Synaptic Plasticity Cellular Component Assembly G-protein Coupled Receptor Signaling Pathway Anatomical Structure Development Receptor Localization To Synapse Dendritic Spine Maintenance	Vocalization Behavior Protein Localization To Synapse Synapse Organization Neuron Development Social Behavior Cell Development Receptor Clustering Neuron Differentiation Cell Morphogenesis Involved In Neuron Differentiation Neuron Projection Morphogenesis Nervous System Development Neuromuscular Process Controlling Balance Synapse Assembly Cell Morphogenesis Involved In Differentiation Receptor Localization To Synapse Dendrite Morphogenesis Neuron Projection Development Generation Of Neurons Cell Projection Morphogenesis Dendritic Spine Morphogenesis Cell Part Morphogenesis Neurogenesis Membrane Depolarization Neuromuscular Process Single-organism Behavior Learning Dendritic Spine Development Dendrite Development Regulation Of Signaling Cell Morphogenesis Dendritic Spine Organization Anatomical Structure Development Adult Behavior Reflex Cell Projection Organization Cell Differentiation Exploration Behavior Synaptic Transmission Behavior Establishment Or Maintenance Of Apical/basal Cell Polarity Regulation Of Ion Transport Developmental Process Positive Regulation Of Excitatory Postsynaptic Membrane Potential Signaling Cell Communication Positive Regulation Of Membrane Potential Learning Or Memory Regulation Of Membrane Potential System Development Cognition
Tagcloud ?		acetylation address carbamylated cepo display e1a epigenetic epo erythropoietin gap43 implications interest issue markedly modifications neurites neuronal neurons neuropsychiatric p300 possibly potentiates psd95 regulate spine subsequent transactivation upregulation yet
Tagcloud (Difference) ?		acetylation address carbamylated cepo display e1a epigenetic epo erythropoietin gap43 implications interest issue markedly modifications neurites neuronal neurons neuropsychiatric p300 possibly potentiates psd95 regulate spine subsequent transactivation upregulation yet
Tagcloud (Intersection) ?