SHANK2 and SSTR2

Number of citations of the paper that reports this interaction (PMID 10373412)
6

Data Source:
HPRD (two hybrid, in vivo, in vitro)

		SHANK2	SSTR2
Gene Name		SH3 and multiple ankyrin repeat domains 2	somatostatin receptor 2
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Photoreceptor Outer Segment Photoreceptor Inner Segment Cellular_component Neurofilament Plasma Membrane Ionotropic Glutamate Receptor Complex Postsynaptic Density Apical Plasma Membrane Cell Junction Growth Cone Brush Border Membrane Neuron Projection Neuronal Cell Body Dendritic Spine Postsynaptic Membrane Ciliary Membrane	Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Neuron Projection
	Molecular Function	Protein Binding SH3 Domain Binding GKAP/Homer Scaffold Activity Ionotropic Glutamate Receptor Binding	Somatostatin Receptor Activity Protein Binding PDZ Domain Binding Neuropeptide Binding
	Biological Process	Synapse Assembly Learning Memory Adult Behavior Social Behavior Exploration Behavior Long-term Synaptic Potentiation Long Term Synaptic Depression Vocalization Behavior	Regulation Of Muscle Contraction G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Neuropeptide Signaling Pathway Cell-cell Signaling Synaptic Transmission Spermatogenesis Response To Nutrient Digestion Negative Regulation Of Cell Proliferation Cerebellum Development Peristalsis Forebrain Development Somatostatin Signaling Pathway Response To Starvation Cellular Response To Glucocorticoid Stimulus Cellular Response To Estradiol Stimulus
Pathways			Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs
Diseases
GWAS		Obesity-related traits ( 23251661) Response to fenofibrate (adiponectin levels) ( 23149075)
Protein-Protein Interactions		15 interactors: ARHGEF7 BAI2 BAIAP2 CTTN DLG4 DLGAP1 DLGAP2 DLGAP3 DLGAP4 DNM2 LPHN1 LPHN2 SHARPIN SLC9A3 SSTR2	9 interactors: APP CORT GNA14 GNAI1 PIK3R1 PTPN6 SHANK1 SHANK2 SST
Entrez ID		22941	6752
HPRD ID		04479	01674
Ensembl ID		ENSG00000162105
Uniprot IDs		C0SPH0 Q9UPX8	P30874
PDB IDs
Enriched GO Terms of Interacting Partners?		Cell-cell Signaling Signaling Cell Communication Synaptic Transmission Nervous System Development Neuron Projection Morphogenesis Dendritic Spine Organization Neuron Projection Development Cell Projection Morphogenesis Cell Part Morphogenesis Regulation Of Cell Morphogenesis Focal Adhesion Assembly Neuron Development Cell Morphogenesis Adherens Junction Assembly Lamellipodium Organization Neuron Differentiation Cell-substrate Junction Assembly Cell Projection Organization Endocytosis Regulation Of Cellular Component Organization Regulation Of Axon Extension Negative Regulation Of Membrane Tubulation Post-Golgi Vesicle-mediated Transport Adherens Junction Organization System Development Regulation Of CD40 Signaling Pathway Protein Linear Polyubiquitination Positive Regulation Of Lamellipodium Morphogenesis Generation Of Neurons Synaptic Vesicle Transport Neurogenesis Somatostatin Signaling Pathway Regulation Of Cell Size Regulation Of Cell Projection Organization Dendrite Development Alpha-amino-3-hydroxy-5-methyl-4-isoxazole Propionate Selective Glutamate Receptor Clustering Regulation Of Grooming Behavior Cell Development Multicellular Organismal Development Axonogenesis Maintenance Of Apical/basal Cell Polarity Regulation Of Lamellipodium Morphogenesis Regulation Of Axonogenesis Regulation Of Synaptic Plasticity Cellular Component Assembly G-protein Coupled Receptor Signaling Pathway Anatomical Structure Development Receptor Localization To Synapse Dendritic Spine Maintenance	Platelet Activation Blood Coagulation Hemostasis Regulation Of Body Fluid Levels Wound Healing Cell Activation Response To Wounding Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Vocalization Behavior Learning G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Cell Surface Receptor Signaling Pathway Adult Behavior G-protein Coupled Receptor Signaling Pathway Synapse Organization Growth Hormone Receptor Signaling Pathway Synaptic Transmission Cellular Response To Growth Hormone Stimulus Signaling Cell Communication Social Behavior Response To Growth Hormone Learning Or Memory Cognition Response To Organonitrogen Compound Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Cell-cell Signaling Response To Hormone Apoptotic Process Programmed Cell Death T Cell Costimulation Neuromuscular Process Controlling Balance Synapse Assembly Determination Of Affect NFAT Protein Import Into Nucleus Cell Death Death Associative Learning Response To Stress Single-organism Behavior Response To Peptide Hormone Signal Transduction Response To Peptide Abortive Mitotic Cell Cycle Synaptic Growth At Neuromuscular Junction Transcription Factor Import Into Nucleus Regulation Of Receptor Activity Memory Neuromuscular Process Cellular Response To Hormone Stimulus
Tagcloud ?		acetylation address carbamylated cepo display e1a epigenetic epo erythropoietin gap43 implications interest issue markedly modifications neurites neuronal neurons neuropsychiatric p300 possibly potentiates psd95 regulate spine subsequent transactivation upregulation yet	analogue appropriate braf cancers detecting dish entero extensive gastro give gives highlighted humanized immunohistochemistry kras list mutational nets neuroendocrine next ngs octreotide others particular pathologists perform rapidy somatostatin suitable
Tagcloud (Difference) ?		acetylation address carbamylated cepo display e1a epigenetic epo erythropoietin gap43 implications interest issue markedly modifications neurites neuronal neurons neuropsychiatric p300 possibly potentiates psd95 regulate spine subsequent transactivation upregulation yet	analogue appropriate braf cancers detecting dish entero extensive gastro give gives highlighted humanized immunohistochemistry kras list mutational nets neuroendocrine next ngs octreotide others particular pathologists perform rapidy somatostatin suitable
Tagcloud (Intersection) ?