SHANK2 and ADGRB2

Number of citations of the paper that reports this interaction (PubMedID 10964907)
0

Data Source:
HPRD (two hybrid)

		SHANK2	ADGRB2
Description		SH3 and multiple ankyrin repeat domains 2	adhesion G protein-coupled receptor B2
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GO Annotations	Cellular Component	Photoreceptor Outer Segment Photoreceptor Inner Segment Cytoplasm Cytosol Neurofilament Plasma Membrane Postsynaptic Density Membrane Apical Plasma Membrane Growth Cone Brush Border Membrane Cell Projection Neuron Projection Neuronal Cell Body Dendritic Spine Synapse Postsynaptic Membrane Ciliary Membrane	Extracellular Region Plasma Membrane Membrane Synapse Glutamatergic Synapse
	Molecular Function	Protein Binding SH3 Domain Binding Synaptic Receptor Adaptor Activity Ionotropic Glutamate Receptor Binding	Transmembrane Signaling Receptor Activity G Protein-coupled Receptor Activity Protein Binding
	Biological Process	Synapse Assembly Learning Positive Regulation Of Cell Population Proliferation Associative Learning Adult Behavior Social Behavior Negative Regulation Of Hippo Signaling Synapse Organization Cognition Long-term Synaptic Potentiation Long-term Synaptic Depression Vocalization Behavior	Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Peripheral Nervous System Development Negative Regulation Of Angiogenesis Calcineurin-NFAT Signaling Cascade Positive Regulation Of Synapse Assembly
Pathways		Neurexins and neuroligins Neurexins and neuroligins
Drugs
Diseases
GWAS		Bipolar disorder ( 31043756 34002096) Eosinophilic esophagitis ( 34506852) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Hip circumference ( 28552196) Hodgkin's lymphoma ( 34216518) Kawasaki disease ( 33692975) Late-onset Alzheimer's disease ( 27770636) Obesity-related traits ( 23251661) Response to fenofibrate (adiponectin levels) ( 23149075) Urate levels in obese individuals ( 25811787)	Asthma ( 31959851) Intraocular pressure ( 29617998 29785010) Smoking status (ever vs never smokers) ( 30643258) Walking pace ( 33128006)
Interacting Genes		21 interacting genes: ACE2 ADGRB2 ADGRL1 ADGRL2 AKT1 ARHGAP12 ARHGEF7 BAIAP2 CTTN DLG4 DLGAP1 DLGAP2 DLGAP3 DLGAP4 DNM2 HOMER1 PPP3CA RIPOR3 SHARPIN SLC9A3 SSTR2	9 interacting genes: ARHGAP1 DLG4 GABPB1 HDHD2 LRP2BP SHANK1 SHANK2 SNTA1 STARD13
Entrez ID		22941	576
HPRD ID		04479	04063
Ensembl ID		ENSG00000162105	ENSG00000121753
Uniprot IDs		A0A590UJ45 A6NHU9 Q9UPX8	A2A3C1 O60241
PDB IDs		8ATJ 8B10	8OEK
Enriched GO Terms of Interacting Partners?		Synapse Glutamatergic Synapse Postsynaptic Specialization Postsynapse Postsynaptic Density Neuron Projection Modulation Of Chemical Synaptic Transmission Vesicle Scission Latrotoxin Receptor Activity Modification Of Postsynaptic Structure Dendritic Spine Modification Of Synaptic Structure Plasma Membrane Cell Projection Morphogenesis Cell Projection PDZ Domain Binding Regulation Of Synapse Organization Regulation Of Cellular Component Organization Membrane Organization Synaptic Vesicle Budding From Presynaptic Endocytic Zone Membrane Regulation Of Cell Projection Organization Membrane Presynapse Cellular Response To Peptide Neuron Spine Synapse Organization Neuron Projection Morphogenesis Regulation Of Postsynapse Organization Regulation Of Nervous System Development Cell Projection Organization Cholinergic Synapse Cell Junction Organization Protein Localization To Membrane Receptor-mediated Endocytosis Clathrin-coated Pit Negative Regulation Of Cellular Component Organization Cell Cortex Signal Transduction Endocytic Vesicle Membrane Negative Regulation Of CGAS/STING Signaling Pathway Positive Regulation Of Fibroblast Migration Molecular Adaptor Activity Lamellipodium Neuromuscular Junction Proline-rich Region Binding Intracellular Protein Transport Neuron Projection Terminus Calcineurin-NFAT Signaling Cascade G Protein-coupled Receptor Signaling Pathway Schaffer Collateral - CA1 Synapse	Vocalization Behavior Ionotropic Glutamate Receptor Binding Learning Synaptic Receptor Adaptor Activity Social Behavior Learning Or Memory Associative Learning Cognition SH3 Domain Binding Dendritic Spine Morphogenesis Dendritic Spine Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis Ionotropic Glutamate Receptor Signaling Pathway Excitatory Synapse Positive Regulation Of Excitatory Postsynaptic Potential Dendritic Spine Organization Ligand-gated Ion Channel Signaling Pathway Neuron Projection Organization Postsynapse Organization Postsynaptic Membrane Neuromuscular Process Controlling Balance Modulation Of Excitatory Postsynaptic Potential Glutamate Receptor Signaling Pathway Postsynaptic Density Negative Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Cell Migration Involved In Sprouting Angiogenesis P2Y1 Nucleotide Receptor Binding Protein Localization To Synapse Determination Of Affect Somatostatin Receptor Binding Scaffold Protein Binding Negative Regulation Of Endothelial Cell Migration Neuron Projection Neuromuscular Junction Protein Localization To Cell Junction PDZ Domain Binding Endothelial Tube Lumen Extension System Process Negative Regulation Of Endocytic Recycling Beta-1 Adrenergic Receptor Binding Regulation Of Grooming Behavior Nervous System Process Lactose Synthase Activity Structural Constituent Of Postsynaptic Density Regulation Of Nervous System Process Regulation Of Membrane Potential Neuromuscular Process Syntrophin Complex N-acetyllactosamine Synthase Activity Beta-N-acetylglucosaminylglycopeptide Beta-1,4-galactosyltransferase Activity
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