PRDX2 and SAT1

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		PRDX2	SAT1
Description		peroxiredoxin 2	spermidine/spermine N1-acetyltransferase 1
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GO Annotations	Cellular Component	Cytoplasm Cytosol Extracellular Exosome	Cytoplasm Cytosol
	Molecular Function	Peroxidase Activity Protein Binding Thioredoxin Peroxidase Activity Antioxidant Activity Oxidoreductase Activity Peroxiredoxin Activity Thioredoxin-dependent Peroxiredoxin Activity	Diamine N-acetyltransferase Activity Protein Binding N-acetyltransferase Activity Transferase Activity Acyltransferase Activity Acyltransferase Activity, Transferring Groups Other Than Amino-acyl Groups Spermidine Binding Identical Protein Binding
	Biological Process	Defense Response To Tumor Cell Respiratory Burst Involved In Inflammatory Response Response To Oxidative Stress Regulation Of Hydrogen Peroxide Metabolic Process Removal Of Superoxide Radicals Positive Regulation Of Blood Coagulation Negative Regulation Of Lipopolysaccharide-mediated Signaling Pathway Response To Lipopolysaccharide Cellular Response To Oxidative Stress T Cell Proliferation Hydrogen Peroxide Metabolic Process Hydrogen Peroxide Catabolic Process Regulation Of Apoptotic Process T Cell Homeostasis Negative Regulation Of Apoptotic Process Positive Regulation Of MAPK Cascade Leukocyte Activation Cell Redox Homeostasis Negative Regulation Of T Cell Differentiation Thymus Development Extrinsic Apoptotic Signaling Pathway Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Angiogenesis Polyamine Biosynthetic Process Putrescine Catabolic Process Spermidine Acetylation Regulation Of Cell Population Proliferation
Pathways		Detoxification of Reactive Oxygen Species TP53 Regulates Metabolic Genes Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models	Interconversion of polyamines
Drugs		3-sulfino-L-alanine N-Carbamoyl-Alanine Copper	N-ethyl-N-[3-(propylamino)propyl]propane-1,3-diamine
Diseases			Keratosis follicularis spinulosa decalvans
GWAS		Platelet distribution width ( 32888494)	Shoulder impingement or rotator cuff tear ( 33482370)
Interacting Genes		24 interacting genes: A2M APOE APP BAD CA4 CD320 CDC37 CDK1 COPS5 ECSIT EXOC6 IFIT5 MAST1 NLGN3 PDGFRB PPP2R1A PPP2R1B PSEN1 RNF32 RPL4 SAT1 SUMO4 TXNDC5 UTY	98 interacting genes: ABCB8 ABHD15 APLP1 B4GALT3 BHLHA9 C19orf25 CASP7 CCDC148 CCDC90B CCHCR1 CDC42EP1 CEP126 CHD3 COPS6 COX6C CRMP1 CSNK2A1 CSNK2A2 DDX39A DGKZ DIPK1B DMRT3 DNPEP EEF1G EIF3D EPHB6 ERG28 EVA1A FAM156A FAM228A FAM86C1P FH FTSJ3 FUNDC2 GAS2L2 GBP2 GDF9 HIF1A HOXB6 HOXB9 HSPB1 HSPE1 INO80C ITGA9 JUNB KAT5 KAT7 KCNA4 KHDC4 LHX3 LNX1 LRIF1 LUC7L2 LYRM7 MED31 MEOX2 MRPL12 MRPL9 MTA1 MYPOP NIF3L1 NMRK2 NTAQ1 PLGRKT PRDX2 PSMA1 PTN RACK1 RBM17 RBM48 REL RELA RPLP1 RPP25 SARAF SAT2 SEPHS1 SETDB1 SNAI2 SPMIP10 TACO1 TCF25 TEAD4 TLE1 TLE5 TNNI1 TP53 TP53TG1 TSC22D4 TUBB2A TXN2 UBE2D3 UNC119 USHBP1 UTP14A VASP VKORC1 ZHX1
Entrez ID		7001	6303
HPRD ID		02763	02431
Ensembl ID		ENSG00000167815	ENSG00000130066
Uniprot IDs		P32119 V9HW12	A0A384NQ10 P21673
PDB IDs		1QMV 5B8A 5B8B 5IJT 7KIZ 7KJ0 7KJ1	2B3U 2B3V 2B4B 2B4D 2B58 2B5G 2F5I 2FXF 2G3T 2JEV
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Amyloid Fibril Formation Regulation Of Amyloid Fibril Formation Lipoprotein Particle Regulation Of Protein Localization To Nucleus Astrocyte Activation Involved In Immune Response Meiotic Sister Chromatid Cohesion, Centromeric Intermediate-density Lipoprotein Particle Growth Factor Receptor Binding Rough Endoplasmic Reticulum Positive Regulation Of Protein Transport Positive Regulation Of Protein Localization Cellular Response To Amyloid-beta Positive Regulation Of Apoptotic Signaling Pathway Extracellular Exosome Positive Regulation Of Establishment Of Protein Localization Regulation Of Signal Transduction Positive Regulation Of Signaling Response To Amyloid-beta Regulation Of Apoptotic Process Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Meiotic Sister Chromatid Cohesion Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Negative Regulation Of Long-term Synaptic Potentiation Regulation Of Programmed Cell Death Regulation Of Dendritic Spine Maintenance Neuron Projection Maintenance Enzyme Binding Positive Regulation Of Proteolysis Low-density Lipoprotein Particle Regulation Of Protein Localization Positive Regulation Of Membrane Protein Ectodomain Proteolysis Regulation Of Apoptotic Signaling Pathway Protein Phosphatase Type 2A Complex Regulation Of Immune System Process Positive Regulation Of Signal Transduction Heparan Sulfate Proteoglycan Binding Astrocyte Activation Negative Regulation Of DNA Binding Regulation Of Immune Response Regulation Of Innate Immune Response Very-low-density Lipoprotein Particle Regulation Of Amyloid-beta Clearance Regulation Of Protein Transport Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Protein Localization To Nucleus High-density Lipoprotein Particle Dendrite Positive Regulation Of Glycolytic Process Amyloid Precursor Protein Metabolic Process	Protein Binding Chromatin
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