PRDX2 and TXNDC5

Number of citations of the paper that reports this interaction (PubMedID 23713588)
0

Data Source:
BioGRID (affinity chromatography technology, enzymatic study)

		PRDX2	TXNDC5
Description		peroxiredoxin 2	thioredoxin domain containing 5
Image
GO Annotations	Cellular Component	Cytoplasm Cytosol Extracellular Exosome	Extracellular Region Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endomembrane System Azurophil Granule Lumen Lysosomal Lumen Intracellular Organelle Lumen Extracellular Exosome
	Molecular Function	Peroxidase Activity Protein Binding Thioredoxin Peroxidase Activity Antioxidant Activity Oxidoreductase Activity Peroxiredoxin Activity Thioredoxin-dependent Peroxiredoxin Activity	Protein Disulfide Isomerase Activity Protein Binding Protein-disulfide Reductase Activity Oxidoreductase Activity Isomerase Activity
	Biological Process	Defense Response To Tumor Cell Respiratory Burst Involved In Inflammatory Response Response To Oxidative Stress Regulation Of Hydrogen Peroxide Metabolic Process Removal Of Superoxide Radicals Positive Regulation Of Blood Coagulation Negative Regulation Of Lipopolysaccharide-mediated Signaling Pathway Response To Lipopolysaccharide Cellular Response To Oxidative Stress T Cell Proliferation Hydrogen Peroxide Metabolic Process Hydrogen Peroxide Catabolic Process Regulation Of Apoptotic Process T Cell Homeostasis Negative Regulation Of Apoptotic Process Positive Regulation Of MAPK Cascade Leukocyte Activation Cell Redox Homeostasis Negative Regulation Of T Cell Differentiation Thymus Development Extrinsic Apoptotic Signaling Pathway Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Protein Folding Negative Regulation Of Apoptotic Process
Pathways		Detoxification of Reactive Oxygen Species TP53 Regulates Metabolic Genes Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models	Lysosome Vesicle Biogenesis Golgi Associated Vesicle Biogenesis Neutrophil degranulation
Drugs		3-sulfino-L-alanine N-Carbamoyl-Alanine Copper
Diseases
GWAS		Platelet distribution width ( 32888494)	Blood protein levels ( 30072576) High chromosomal aberration frequency (chromatid type) ( 31586183) Mean corpuscular hemoglobin ( 32888494) Pelvic organ prolapse ( 32184442)
Interacting Genes		24 interacting genes: A2M APOE APP BAD CA4 CD320 CDC37 CDK1 COPS5 ECSIT EXOC6 IFIT5 MAST1 NLGN3 PDGFRB PPP2R1A PPP2R1B PSEN1 RNF32 RPL4 SAT1 SUMO4 TXNDC5 UTY	29 interacting genes: APP AR BLZF1 CEBPA EDEM3 EFEMP1 FLACC1 GMPPB KRT38 KRT40 KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP4-12 KRTAP4-2 LHX4 MGAT5B NOTCH2NLA OGT PJA1 PRDX2 RAB3IP SPRY2 TRIM23 TRIM42 TRIP6 UBQLN2
Entrez ID		7001	81567
HPRD ID		02763	18249
Ensembl ID		ENSG00000167815	ENSG00000239264
Uniprot IDs		P32119 V9HW12	A0A024QZV0 Q8NBS9
PDB IDs		1QMV 5B8A 5B8B 5IJT 7KIZ 7KJ0 7KJ1	2DIZ 3UJ1 3UVT 3WGD 3WGE 3WGX 8EKY
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Amyloid Fibril Formation Regulation Of Amyloid Fibril Formation Lipoprotein Particle Regulation Of Protein Localization To Nucleus Astrocyte Activation Involved In Immune Response Meiotic Sister Chromatid Cohesion, Centromeric Intermediate-density Lipoprotein Particle Growth Factor Receptor Binding Rough Endoplasmic Reticulum Positive Regulation Of Protein Transport Positive Regulation Of Protein Localization Cellular Response To Amyloid-beta Positive Regulation Of Apoptotic Signaling Pathway Extracellular Exosome Positive Regulation Of Establishment Of Protein Localization Regulation Of Signal Transduction Positive Regulation Of Signaling Response To Amyloid-beta Regulation Of Apoptotic Process Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Meiotic Sister Chromatid Cohesion Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Negative Regulation Of Long-term Synaptic Potentiation Regulation Of Programmed Cell Death Regulation Of Dendritic Spine Maintenance Neuron Projection Maintenance Enzyme Binding Positive Regulation Of Proteolysis Low-density Lipoprotein Particle Regulation Of Protein Localization Positive Regulation Of Membrane Protein Ectodomain Proteolysis Regulation Of Apoptotic Signaling Pathway Protein Phosphatase Type 2A Complex Regulation Of Immune System Process Positive Regulation Of Signal Transduction Heparan Sulfate Proteoglycan Binding Astrocyte Activation Negative Regulation Of DNA Binding Regulation Of Immune Response Regulation Of Innate Immune Response Very-low-density Lipoprotein Particle Regulation Of Amyloid-beta Clearance Regulation Of Protein Transport Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Protein Localization To Nucleus High-density Lipoprotein Particle Dendrite Positive Regulation Of Glycolytic Process Amyloid Precursor Protein Metabolic Process	Keratin Filament Intermediate Filament Protein Glycosylation Macromolecule Glycosylation Glycosylation Hair Cycle
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