PRDX2 and CD320

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		PRDX2	CD320
Description		peroxiredoxin 2	CD320 molecule
Image
GO Annotations	Cellular Component	Cytoplasm Cytosol Extracellular Exosome	Endoplasmic Reticulum Plasma Membrane Membrane
	Molecular Function	Peroxidase Activity Protein Binding Thioredoxin Peroxidase Activity Antioxidant Activity Oxidoreductase Activity Peroxiredoxin Activity Thioredoxin-dependent Peroxiredoxin Activity	Calcium Ion Binding Protein Binding Growth Factor Activity Cobalamin Binding Cargo Receptor Activity Metal Ion Binding
	Biological Process	Defense Response To Tumor Cell Respiratory Burst Involved In Inflammatory Response Response To Oxidative Stress Regulation Of Hydrogen Peroxide Metabolic Process Removal Of Superoxide Radicals Positive Regulation Of Blood Coagulation Negative Regulation Of Lipopolysaccharide-mediated Signaling Pathway Response To Lipopolysaccharide Cellular Response To Oxidative Stress T Cell Proliferation Hydrogen Peroxide Metabolic Process Hydrogen Peroxide Catabolic Process Regulation Of Apoptotic Process T Cell Homeostasis Negative Regulation Of Apoptotic Process Positive Regulation Of MAPK Cascade Leukocyte Activation Cell Redox Homeostasis Negative Regulation Of T Cell Differentiation Thymus Development Extrinsic Apoptotic Signaling Pathway Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Signal Transduction Cobalamin Transport Vesicle-mediated Transport Regulation Of Vitamin Metabolic Process Positive Regulation Of B Cell Proliferation B Cell Costimulation
Pathways		Detoxification of Reactive Oxygen Species TP53 Regulates Metabolic Genes Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models	Defective CD320 causes MMATC Transport of RCbl within the body
Drugs		3-sulfino-L-alanine N-Carbamoyl-Alanine Copper
Diseases
GWAS		Platelet distribution width ( 32888494)	Obsessive-compulsive disorder ( 30456828)
Interacting Genes		24 interacting genes: A2M APOE APP BAD CA4 CD320 CDC37 CDK1 COPS5 ECSIT EXOC6 IFIT5 MAST1 NLGN3 PDGFRB PPP2R1A PPP2R1B PSEN1 RNF32 RPL4 SAT1 SUMO4 TXNDC5 UTY	1 interacting genes: PRDX2
Entrez ID		7001	51293
HPRD ID		02763	05929
Ensembl ID		ENSG00000167815	ENSG00000167775
Uniprot IDs		P32119 V9HW12	Q9NPF0
PDB IDs		1QMV 5B8A 5B8B 5IJT 7KIZ 7KJ0 7KJ1	4ZRP 4ZRQ 7QBD 7QBE 7QBF 7QBG
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Amyloid Fibril Formation Regulation Of Amyloid Fibril Formation Lipoprotein Particle Regulation Of Protein Localization To Nucleus Astrocyte Activation Involved In Immune Response Meiotic Sister Chromatid Cohesion, Centromeric Intermediate-density Lipoprotein Particle Growth Factor Receptor Binding Rough Endoplasmic Reticulum Positive Regulation Of Protein Transport Positive Regulation Of Protein Localization Cellular Response To Amyloid-beta Positive Regulation Of Apoptotic Signaling Pathway Extracellular Exosome Positive Regulation Of Establishment Of Protein Localization Regulation Of Signal Transduction Positive Regulation Of Signaling Response To Amyloid-beta Regulation Of Apoptotic Process Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Meiotic Sister Chromatid Cohesion Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Negative Regulation Of Long-term Synaptic Potentiation Regulation Of Programmed Cell Death Regulation Of Dendritic Spine Maintenance Neuron Projection Maintenance Enzyme Binding Positive Regulation Of Proteolysis Low-density Lipoprotein Particle Regulation Of Protein Localization Positive Regulation Of Membrane Protein Ectodomain Proteolysis Regulation Of Apoptotic Signaling Pathway Protein Phosphatase Type 2A Complex Regulation Of Immune System Process Positive Regulation Of Signal Transduction Heparan Sulfate Proteoglycan Binding Astrocyte Activation Negative Regulation Of DNA Binding Regulation Of Immune Response Regulation Of Innate Immune Response Very-low-density Lipoprotein Particle Regulation Of Amyloid-beta Clearance Regulation Of Protein Transport Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Protein Localization To Nucleus High-density Lipoprotein Particle Dendrite Positive Regulation Of Glycolytic Process Amyloid Precursor Protein Metabolic Process	Respiratory Burst Involved In Inflammatory Response Thioredoxin-dependent Peroxiredoxin Activity Peroxiredoxin Activity Thioredoxin Peroxidase Activity Positive Regulation Of Coagulation Regulation Of Hydrogen Peroxide Metabolic Process T Cell Homeostasis Hydrogen Peroxide Catabolic Process Peroxidase Activity Respiratory Burst Involved In Defense Response Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Antioxidant Activity Hydrogen Peroxide Metabolic Process Defense Response To Tumor Cell Removal Of Superoxide Radicals Negative Regulation Of Lipopolysaccharide-mediated Signaling Pathway Regulation Of Lipopolysaccharide-mediated Signaling Pathway Respiratory Burst Positive Regulation Of Blood Coagulation Production Of Molecular Mediator Involved In Inflammatory Response Cell Redox Homeostasis Superoxide Metabolic Process Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Thymus Development Negative Regulation Of T Cell Differentiation Positive Regulation Of Wound Healing Negative Regulation Of Lymphocyte Differentiation T Cell Proliferation Lymphocyte Homeostasis Cellular Oxidant Detoxification Regulation Of Hemostasis Leukocyte Homeostasis Regulation Of Blood Coagulation Hematopoietic Or Lymphoid Organ Development Reactive Oxygen Species Metabolic Process Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Cellular Detoxification Extrinsic Apoptotic Signaling Pathway Lymphocyte Proliferation Negative Regulation Of Hemopoiesis Mononuclear Cell Proliferation Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of Wound Healing Leukocyte Proliferation Negative Regulation Of T Cell Activation Negative Regulation Of Leukocyte Cell-cell Adhesion Regulation Of Extrinsic Apoptotic Signaling Pathway Negative Regulation Of Lymphocyte Activation Regulation Of Response To Wounding Regulation Of T Cell Differentiation
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