PRDX2 and CA4

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		PRDX2	CA4
Gene Name		peroxiredoxin 2	carbonic anhydrase IV
Image
Gene Ontology Annotations	Cellular Component	Cytoplasm Cytosol Extracellular Vesicular Exosome	Rough Endoplasmic Reticulum Endoplasmic Reticulum-Golgi Intermediate Compartment Golgi Apparatus Trans-Golgi Network Plasma Membrane Cell Surface Membrane Basolateral Plasma Membrane Apical Plasma Membrane Sarcoplasmic Reticulum Transport Vesicle Membrane Secretory Granule Membrane Anchored Component Of External Side Of Plasma Membrane Brush Border Membrane Sarcolemma Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome
	Molecular Function	Thioredoxin Peroxidase Activity Antioxidant Activity	Carbonate Dehydratase Activity Protein Binding Zinc Ion Binding
	Biological Process	Response To Reactive Oxygen Species Response To Oxidative Stress Removal Of Superoxide Radicals Cellular Response To Oxidative Stress Hydrogen Peroxide Catabolic Process Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Neuron Apoptotic Process Oxidation-reduction Process	One-carbon Metabolic Process Bicarbonate Transport Response To Drug Small Molecule Metabolic Process Organ Development Response To Steroid Hormone
Pathways		Detoxification of Reactive Oxygen Species	O2/CO2 exchange in erythrocytes Erythrocytes take up carbon dioxide and release oxygen Erythrocytes take up oxygen and release carbon dioxide Reversible hydration of carbon dioxide
Drugs		3-Sulfinoalanine N-Carbamoyl-Alanine	Methyclothiazide Topiramate Ethoxzolamide Bendroflumethiazide Benzthiazide Cyclothiazide Methazolamide Hydroflumethiazide Acetazolamide Dorzolamide Chlorothiazide Zonisamide Hydrochlorothiazide Trichlormethiazide Dichlorphenamide Brinzolamide Ellagic Acid
Diseases
GWAS
Protein-Protein Interactions		23 interactors: A2M APOE APP BAD CA4 CD320 CDC37 COPS5 ECSIT EXOC6 IFIT5 MAST1 NLGN3 PDGFRB PPP2R1A PPP2R1B PRDX4 PSEN1 RNF32 SAT1 SUMO4 UTY YWHAZ	5 interactors: PIH1D1 PRDX2 SLC4A1 SLC4A3 SLC4A4
Entrez ID		7001	762
HPRD ID		02763	00261
Ensembl ID		ENSG00000167815	ENSG00000167434
Uniprot IDs		A6NIW5 B4DF70 P32119	P22748 Q6FHI7
PDB IDs		1QMV	1ZNC 3F7B 3F7U 3FW3
Enriched GO Terms of Interacting Partners?		Exocytosis Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Regulation Of Signal Transduction Regulation Of Signaling Establishment Of Localization In Cell Secretion By Cell Regulation Of Kinase Activity Regulation Of Phosphorylation Positive Regulation Of Cell Death Secretion Intracellular Signal Transduction Cellular Localization Cellular Component Assembly Vesicle-mediated Transport Regulation Of Cellular Component Organization Regulation Of Phosphorus Metabolic Process Positive Regulation Of Apoptotic Signaling Pathway Response To Oxidative Stress Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Protein Kinase Activity Synapse Assembly Protein Metabolic Process Positive Regulation Of Signal Transduction Membrane Organization Immune Response Regulation Of MAP Kinase Activity Positive Regulation Of Proteolysis Regulation Of Catalytic Activity Homeostatic Process Anatomical Structure Morphogenesis Positive Regulation Of Apoptotic Process Regulation Of Receptor Activity Positive Regulation Of Programmed Cell Death Apoptotic Process Regulation Of MAPK Cascade Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Regulation Of Cellular Protein Metabolic Process Regulation Of Apoptotic Process Programmed Cell Death Developmental Process Cell Death Anion Transport Regulation Of Proteolysis Death Regulation Of Epidermal Growth Factor-activated Receptor Activity Regulation Of Protein Phosphorylation Regulation Of Cell Death Mitochondrial Transport Postsynaptic Membrane Organization Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway	Bicarbonate Transport Regulation Of Intracellular PH Regulation Of Cellular PH Regulation Of PH Inorganic Anion Transport Anion Transmembrane Transport Organic Anion Transport Cellular Cation Homeostasis Cellular Ion Homeostasis Cellular Chemical Homeostasis Ion Homeostasis Anion Transport Chloride Transmembrane Transport Cellular Homeostasis Chloride Transport Chemical Homeostasis Box C/D SnoRNP Assembly Ion Transmembrane Transport Homeostatic Process Transmembrane Transport Ion Transport Hydrogen Peroxide Catabolic Process Removal Of Superoxide Radicals Cellular Response To Superoxide Response To Superoxide Response To Oxygen Radical Hydrogen Peroxide Metabolic Process Superoxide Metabolic Process Cellular Response To Reactive Oxygen Species
Tagcloud ?		2de angustifolia apoa1 atp5a1 atp5a1were bioinformatics caliber david diminishing dysregulated histopathology hspa5 kegg la lavandula lavender le likewise ontology operate pharmaceutically predictedinteractions scrutinized searching slowing snca string sum tof	adrenal adrenalectomy adx alteration animals autoradiography ca1 decreased dentate hippocampus histochemistry hormones hybridization igf influenced insulin level like long mrna noted receptor receptors regions situ studied suggesting term vitro
Tagcloud (Difference) ?		2de angustifolia apoa1 atp5a1 atp5a1were bioinformatics caliber david diminishing dysregulated histopathology hspa5 kegg la lavandula lavender le likewise ontology operate pharmaceutically predictedinteractions scrutinized searching slowing snca string sum tof	adrenal adrenalectomy adx alteration animals autoradiography ca1 decreased dentate hippocampus histochemistry hormones hybridization igf influenced insulin level like long mrna noted receptor receptors regions situ studied suggesting term vitro
Tagcloud (Intersection) ?