EIF2S3 and NDRG1

Number of citations of the paper that reports this interaction (PMID 17220478)
17

Data Source:
HPRD (in vivo)

		EIF2S3	NDRG1
Gene Name		eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa	N-myc downstream regulated 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Extracellular Vesicular Exosome	Nucleus Cytoplasm Centrosome Cytosol Microtubule Plasma Membrane Cell-cell Adherens Junction Microtubule Cytoskeleton Perinuclear Region Of Cytoplasm Recycling Endosome Membrane Extracellular Vesicular Exosome
	Molecular Function	Translation Initiation Factor Activity GTPase Activity Protein Binding GTP Binding Translation Factor Activity, Nucleic Acid Binding	Protein Binding Microtubule Binding Rab GTPase Binding Gamma-tubulin Binding Cadherin Binding
	Biological Process	Translation Translational Initiation Gene Expression Cellular Protein Metabolic Process	Response To Metal Ion DNA Damage Response, Signal Transduction By P53 Class Mediator Peripheral Nervous System Myelin Maintenance Mast Cell Activation Cellular Response To Hypoxia Positive Regulation Of Spindle Checkpoint
Pathways		Ribosomal scanning and start codon recognition Recycling of eIF2:GDP Translation initiation complex formation Formation of the ternary complex, and subsequently, the 43S complex GTP hydrolysis and joining of the 60S ribosomal subunit Translation Eukaryotic Translation Initiation Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S Cap-dependent Translation Initiation L13a-mediated translational silencing of Ceruloplasmin expression
Drugs
Diseases
GWAS			Post-traumatic stress disorder (asjusted for relatedness) ( 23726511)
Protein-Protein Interactions		2 interactors: METAP2 NDRG1	64 interactors: ACSL3 ACTG1 AP1M2 AP2M1 ARL4D ATP1A1 CANX CDH1 CLTC CNDP2 COPB2 CTNNB1 DDX1 DDX5 DLST EEF1G EEF2 EIF2S3 EIF3E EWSR1 FASN HNRNPF HNRNPH1 HNRNPU HSD17B4 HSP90AA1 HSPA5 ILF3 KIF5B LDHA MAOA MLH1 MME NCL PABPC1 PHYHIP PKM PPP2R2A PRKACA PSMC2 PSMC3 PSMD2 RPL24 RPL3 RPL4 RPN2 RPS16 RPS20 RPS26 RPS3 RPS6 RPS8 RUVBL2 S100B SEC23A SGK1 SHMT2 TAF9 TARS TLE3 UPF1 VCP XRCC5 ZNF155
Entrez ID		1968	10397
HPRD ID		02155	05586
Ensembl ID			ENSG00000104419
Uniprot IDs		P41091	Q8N959 Q92597
PDB IDs
Enriched GO Terms of Interacting Partners?		Protein Initiator Methionine Removal Positive Regulation Of Spindle Checkpoint Peptidyl-methionine Modification Positive Regulation Of Cell Cycle Checkpoint Peripheral Nervous System Myelin Maintenance Regulation Of Spindle Checkpoint Regulation Of Rhodopsin Mediated Signaling Pathway Response To Abiotic Stimulus N-terminal Protein Amino Acid Modification Myelin Maintenance Rhodopsin Mediated Signaling Pathway Mast Cell Activation Regulation Of Cell Cycle Checkpoint Myelination In Peripheral Nervous System Schwann Cell Development Schwann Cell Differentiation Phototransduction, Visible Light DNA Damage Response, Signal Transduction By P53 Class Mediator Detection Of Visible Light Signal Transduction In Response To DNA Damage Cellular Response To Light Stimulus Phototransduction Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Glial Cell Development Peripheral Nervous System Development Detection Of Light Stimulus Cellular Response To Oxygen Levels Signal Transduction By P53 Class Mediator Cellular Response To Radiation Myelination Axon Ensheathment Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Detection Of Abiotic Stimulus Glial Cell Differentiation Plasma Membrane Organization Positive Regulation Of Cell Cycle Process Gliogenesis Protein Processing	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Nuclear-transcribed MRNA Catabolic Process MRNA Catabolic Process RNA Catabolic Process MRNA Metabolic Process Gene Expression Cellular Metabolic Process Cellular Macromolecule Catabolic Process Membrane Organization Protein Localization To Endoplasmic Reticulum SRP-dependent Cotranslational Protein Targeting To Membrane Catabolic Process Cotranslational Protein Targeting To Membrane Protein Targeting To ER Establishment Of Protein Localization To Endoplasmic Reticulum Aromatic Compound Catabolic Process Viral Process Translational Initiation Establishment Of Protein Localization To Membrane Translational Elongation Cellular Nitrogen Compound Metabolic Process Viral Transcription Translation Nitrogen Compound Metabolic Process Establishment Of Localization In Cell Cellular Localization Cellular Protein Localization Protein Targeting To Membrane Biosynthetic Process Establishment Of Protein Localization Intracellular Protein Transport Establishment Of Protein Localization To Organelle Translational Termination Protein Localization Protein Localization To Membrane Protein Localization To Organelle Cellular Protein Metabolic Process Cellular Macromolecule Biosynthetic Process Protein Targeting Macromolecule Biosynthetic Process Protein Transport Cellular Protein Complex Disassembly RNA Metabolic Process Viral Life Cycle Cytoplasmic Transport Protein Complex Disassembly Intracellular Transport Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process
Tagcloud ?			4ebp1 allosteric bid dosing dysregulated es ewing integrates liposarcoma master mln0128 mtorc1 mtorc2 osteosarcoma pakt pan promise rapalogues rapamycin reactivation rhabdomyosarcoma rms sarcoma schedule schedules sheath striking synovial tiw
Tagcloud (Difference) ?			4ebp1 allosteric bid dosing dysregulated es ewing integrates liposarcoma master mln0128 mtorc1 mtorc2 osteosarcoma pakt pan promise rapalogues rapamycin reactivation rhabdomyosarcoma rms sarcoma schedule schedules sheath striking synovial tiw
Tagcloud (Intersection) ?