EIF2S3

Name	eukaryotic translation initiation factor 2 subunit gamma
Structure
Interactors	3 interactors: CEBPA METAP2 NDRG1
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Eukaryotic Translation Initiation Factor 2 Complex Extracellular Exosome
	Molecular Function	TRNA Binding Nucleotide Binding Translation Initiation Factor Activity GTPase Activity Protein Binding GTP Binding Translation Factor Activity, RNA Binding Hydrolase Activity Cadherin Binding Methionyl-initiator Methionine TRNA Binding
	Biological Process	Formation Of Translation Preinitiation Complex Cytoplasmic Translational Initiation Translation Translational Initiation
Pathways	L13a-mediated translational silencing of Ceruloplasmin expression PERK regulates gene expression PERK regulates gene expression ABC-family proteins mediated transport Translation initiation complex formation Formation of the ternary complex, and subsequently, the 43S complex Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit Recycling of eIF2:GDP Response of EIF2AK4 (GCN2) to amino acid deficiency Response of EIF2AK1 (HRI) to heme deficiency PKR-mediated signaling Cellular response to mitochondrial stress
Drugs	Guanosine-5'-Diphosphate
GWAS	Prostate-specific antigen levels ( 28139693 )
Entrez ID	1968
HPRD ID	02155
Ensembl ID	ENSG00000130741
Uniprot IDs	P41091
PDB IDs	6FEC 6K71 6K72 6O81 6O85 6YBV 6ZMW 6ZP4 7A09 7D43 7F66 7F67 7QP6 7QP7 8OZ0 8PHD 8PHV 8PJ1 8PJ2 8PJ3 8PJ4 8PPL 8QZZ
GO Terms Enriched among Interactors ?	CHOP-C/EBP Complex RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Response To Vitamin B2 White Fat Cell Proliferation C/EBP Complex Negative Regulation Of Hematopoietic Stem Cell Proliferation Rb-E2F Complex Nickel Cation Binding Initiator Methionyl Aminopeptidase Activity Response To Phenylpropanoid Response To Metal Ion Fat Cell Proliferation Mast Cell Activation Peripheral Nervous System Myelin Maintenance Response To Lithium Ion Transcription By RNA Polymerase I Urea Metabolic Process Regulation Of Hematopoietic Stem Cell Proliferation Cellular Response To Lithium Ion HMG Box Domain Binding Nitrogen Cycle Metabolic Process White Fat Cell Differentiation Urea Cycle Interleukin-6-mediated Signaling Pathway STAT Family Protein Binding Osteoblast Development Myelin Maintenance Metalloexopeptidase Activity Hematopoietic Stem Cell Proliferation Embryonic Placenta Development Epithelial Cell Maturation Metalloaminopeptidase Activity Brown Fat Cell Differentiation Granulocyte Differentiation Positive Regulation Of Macrophage Activation Negative Regulation Of Stem Cell Proliferation Negative Regulation Of Cell Population Proliferation Aminopeptidase Activity Gamma-tubulin Binding