MBD1 and SMAD7

Number of citations of the paper that reports this interaction (PubMedID 15231748)
54

Data Source:
HPRD (two hybrid)

		MBD1	SMAD7
Description		methyl-CpG binding domain protein 1	SMAD family member 7
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome Nuclear Matrix Nuclear Speck	Chromatin Fibrillar Center Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Centrosome Cytosol Plasma Membrane Adherens Junction Protein-containing Complex Ciliary Basal Body Heteromeric SMAD Protein Complex
	Molecular Function	DNA Binding Protein Binding Zinc Ion Binding Methyl-CpG Binding Double-stranded Methylated DNA Binding Unmethylated CpG Binding Metal Ion Binding	Transcription Corepressor Activity Protein Binding Collagen Binding Beta-catenin Binding Ubiquitin Protein Ligase Binding Type I Transforming Growth Factor Beta Receptor Binding Metal Ion Binding I-SMAD Binding Activin Receptor Binding Transcription Regulator Inhibitor Activity Ubiquitin-like Ligase-substrate Adaptor Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II DNA Methylation-dependent Constitutive Heterochromatin Formation Transcription By RNA Polymerase II Negative Regulation Of DNA-templated Transcription	Negative Regulation Of Transcription By RNA Polymerase II Ureteric Bud Development Negative Regulation Of T Cell Cytokine Production Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transforming Growth Factor Beta Receptor Signaling Pathway Anatomical Structure Morphogenesis Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Transcription By Competitive Promoter Binding Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Cell Differentiation Negative Regulation Of Ossification Negative Regulation Of Cell Migration Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of BMP Signaling Pathway Protein-containing Complex Localization Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Activin Receptor Signaling Pathway Protein-containing Complex Disassembly Adherens Junction Assembly Response To Laminar Fluid Shear Stress Negative Regulation Of Cell Differentiation Artery Morphogenesis Protein Stabilization Ventricular Cardiac Muscle Tissue Morphogenesis Regulation Of Cardiac Muscle Contraction Regulation Of Ventricular Cardiac Muscle Cell Membrane Depolarization Negative Regulation Of SMAD Protein Signal Transduction SMAD Protein Signal Transduction Ventricular Septum Morphogenesis Cellular Response To Growth Factor Stimulus Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Negative Regulation Of Chondrocyte Proliferation Positive Regulation Of Chondrocyte Hypertrophy Beta-catenin Destruction Complex Disassembly Cellular Response To Leukemia Inhibitory Factor Positive Regulation Of Cell-cell Adhesion Mediated By Cadherin Negative Regulation Of T-helper 17 Type Immune Response Negative Regulation Of T-helper 17 Cell Differentiation
Pathways		SUMOylation of transcription cofactors	Signaling by BMP Downregulation of TGF-beta receptor signaling Downregulation of TGF-beta receptor signaling Downregulation of SMAD2/3:SMAD4 transcriptional activity SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription UCH proteinases Ub-specific processing proteases Interferon gamma signaling
Drugs
Diseases
GWAS		Chronic lymphocytic leukemia ( 28165464)	Asthma ( 32296059) Atrial fibrillation ( 29892015 30061737) Colorectal cancer ( 24836286 29471430 29228715 17934461 30529582 26151821 25990418 24448986 23266556 31826910 21761138 18372905 18372901) Colorectal cancer or advanced adenoma ( 30510241) Coronary artery disease ( 33020668) Creatinine levels ( 29403010) Dental caries ( 23064961) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Estimated glomerular filtration rate ( 30604766 31015462 31152163) Glomerular filtration rate ( 29403010) Heel bone mineral density ( 30598549) Hematocrit ( 27863252 32888494) Hemoglobin ( 32888494) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 32327693) Inflammatory bowel disease ( 23128233) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Myocardial infarction ( 33532862) Parental longevity (at least one long-lived parent) ( 27816938) Red blood cell count ( 32888494 27863252) Serum alkaline phosphatase levels ( 33547301)
Interacting Genes		47 interacting genes: APP ATF7IP ATF7IP2 ATXN1L C1QBP CBX4 CBX5 CCDC136 CHAF1A COPE DVL3 ECT2 EEF1G GRN HDAC3 HIPK3 HTT HUNK JAG2 LTBP3 LTBP4 MDFI MEGF6 NELL1 NELL2 NOTCH1 NOTCH3 OASL PIAS1 PIAS2 POMGNT1 RNF2 SETDB1 SLC25A3 SMAD1 SMAD3 SMAD5 SMAD7 SMAD9 SNAPC2 SP1 SUV39H1 TENM1 TIAM1 TNC ZNF384 ZNF512B	58 interacting genes: ACVR1B AKT1 ASH1L AXIN1 AXIN2 BMPR1B CBL CTNNB1 CXXC5 DVL1 EP300 ERBIN HAT1 HEYL KDM2A MAP2K3 MAP2K6 MAP3K7 MAPK14 MBD1 MRTFB MYOD1 NEDD4L PARD3 PIAS1 PIAS4 RNF111 SASH3 SETD7 SIRT1 SMAD2 SMAD3 SMAD4 SMAD6 SMURF1 SMURF2 SOX13 SOX5 SOX7 STAMBP STAMBPL1 STRAP TAB1 TGFB1I1 TGFBR1 TGFBR2 TTF1 TTF2 UBE2L3 UCHL5 USP2 WWP2 XRCC6 YAP1 ZBTB11 ZBTB44 ZEB1 ZNF107
Entrez ID		4152	4092
HPRD ID		01133	04241
Ensembl ID		ENSG00000141644	ENSG00000101665
Uniprot IDs		A0A994J7H0 A8K654 B4DI41 B4DUR3 Q9UIS9	B3KYA8 O15105
PDB IDs		1D9N 1IG4 4D4W 5W9Q 6D1T	2DJY 2KXQ 2LTV 2LTW 2LTX 2LTY 2LTZ
Enriched GO Terms of Interacting Partners?		Heteromeric SMAD Protein Complex SMAD Protein Signal Transduction Negative Regulation Of Transcription By RNA Polymerase II Transforming Growth Factor Beta Receptor Signaling Pathway I-SMAD Binding SMAD Protein Complex Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Metabolic Process Regulation Of Transcription By RNA Polymerase II Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Negative Regulation Of Nucleobase-containing Compound Metabolic Process Chromatin Binding Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Negative Regulation Of Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of Ossification DEAD/H-box RNA Helicase Binding Positive Regulation Of Developmental Process Transcription Corepressor Activity Kidney Epithelium Development Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of MiRNA Transcription Response To Growth Factor Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Regulation Of Metabolic Process Regulation Of Gene Expression Transcription Regulator Complex Nucleus Regulation Of Cell Population Proliferation Regulation Of MiRNA Metabolic Process Ureteric Bud Development SUMO Ligase Activity Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Ossification Nucleoplasm Mesonephric Tubule Development Mesonephric Epithelium Development Epigenetic Regulation Of Gene Expression Cellular Response To Growth Factor Stimulus Positive Regulation Of Cell Differentiation Auditory Receptor Cell Fate Commitment Osteoblast Fate Commitment SUMO Transferase Activity	I-SMAD Binding Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process SMAD Binding Regulation Of Signal Transduction Regulation Of RNA Metabolic Process Regulation Of Primary Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cell Differentiation Positive Regulation Of Developmental Process Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Cell Communication Regulation Of Signaling Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Response To Growth Factor Cellular Response To Growth Factor Stimulus Positive Regulation Of Macromolecule Metabolic Process Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process Positive Regulation Of Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Regulation Of Developmental Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Metabolic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Regulation Of Cell Differentiation Ubiquitin Protein Ligase Binding Tissue Development Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Signal Transduction Regulation Of Multicellular Organismal Process Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Nucleus Regulation Of Cellular Response To Growth Factor Stimulus Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Biosynthetic Process Cell Surface Receptor Signaling Pathway Positive Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Signal Transduction Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Cell Communication
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