MBD1 and NELL2

Number of citations of the paper that reports this interaction (PubMedID 21653829)
54

Data Source:
BioGRID (affinity chromatography technology, two hybrid)

		MBD1	NELL2
Description		methyl-CpG binding domain protein 1	neural EGFL like 2
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome Nuclear Matrix Nuclear Speck	Extracellular Region Extracellular Space Cytoplasm
	Molecular Function	DNA Binding Protein Binding Zinc Ion Binding Methyl-CpG Binding Double-stranded Methylated DNA Binding Unmethylated CpG Binding Metal Ion Binding	Protein Kinase C Binding Calcium Ion Binding Protein Binding Heparin Binding Identical Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II DNA Methylation-dependent Constitutive Heterochromatin Formation Transcription By RNA Polymerase II Negative Regulation Of DNA-templated Transcription	Nervous System Development Fertilization Neuron Cellular Homeostasis Commissural Neuron Axon Guidance
Pathways		SUMOylation of transcription cofactors	Regulation of commissural axon pathfinding by SLIT and ROBO
Drugs
Diseases
GWAS		Chronic lymphocytic leukemia ( 28165464)	Inflammatory bowel disease ( 27569725) Waist circumference ( 28552196)
Interacting Genes		47 interacting genes: APP ATF7IP ATF7IP2 ATXN1L C1QBP CBX4 CBX5 CCDC136 CHAF1A COPE DVL3 ECT2 EEF1G GRN HDAC3 HIPK3 HTT HUNK JAG2 LTBP3 LTBP4 MDFI MEGF6 NELL1 NELL2 NOTCH1 NOTCH3 OASL PIAS1 PIAS2 POMGNT1 RNF2 SETDB1 SLC25A3 SMAD1 SMAD3 SMAD5 SMAD7 SMAD9 SNAPC2 SP1 SUV39H1 TENM1 TIAM1 TNC ZNF384 ZNF512B	9 interacting genes: ARX ATN1 ATXN7 CACNA1A DYRK1A GFI1B HOXA1 MBD1 PRKAR1A
Entrez ID		4152	4753
HPRD ID		01133	11891
Ensembl ID		ENSG00000141644	ENSG00000184613
Uniprot IDs		A0A994J7H0 A8K654 B4DI41 B4DUR3 Q9UIS9	B7Z625 Q99435
PDB IDs		1D9N 1IG4 4D4W 5W9Q 6D1T	6POG
Enriched GO Terms of Interacting Partners?		Heteromeric SMAD Protein Complex SMAD Protein Signal Transduction Negative Regulation Of Transcription By RNA Polymerase II Transforming Growth Factor Beta Receptor Signaling Pathway I-SMAD Binding SMAD Protein Complex Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Metabolic Process Regulation Of Transcription By RNA Polymerase II Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Negative Regulation Of Nucleobase-containing Compound Metabolic Process Chromatin Binding Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Negative Regulation Of Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of Ossification DEAD/H-box RNA Helicase Binding Positive Regulation Of Developmental Process Transcription Corepressor Activity Kidney Epithelium Development Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of MiRNA Transcription Response To Growth Factor Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Regulation Of Metabolic Process Regulation Of Gene Expression Transcription Regulator Complex Nucleus Regulation Of Cell Population Proliferation Regulation Of MiRNA Metabolic Process Ureteric Bud Development SUMO Ligase Activity Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Ossification Nucleoplasm Mesonephric Tubule Development Mesonephric Epithelium Development Epigenetic Regulation Of Gene Expression Cellular Response To Growth Factor Stimulus Positive Regulation Of Cell Differentiation Auditory Receptor Cell Fate Commitment Osteoblast Fate Commitment SUMO Transferase Activity	Regulation Of Transcription By RNA Polymerase II Nuclear Matrix Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process RNA Polymerase II CTD Heptapeptide Repeat Kinase Activity Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Microtubule Polymerization Or Depolymerization Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Transcription Coactivator Activity Regulation Of Metabolic Process Histone H3T45 Kinase Activity Semicircular Canal Formation Histone H4K8ac Reader Activity Negative Regulation Of RNA Metabolic Process Negative Regulation Of Biosynthetic Process Nucleus Positive Regulation Of Metabolic Process Chromatin Organization Negative Regulation Of Nucleobase-containing Compound Metabolic Process Abducens Nerve Formation Optokinetic Behavior Histone H3K9ac Reader Activity Histone H4K5ac Reader Activity Histone H4K12ac Reader Activity Embryonic Olfactory Bulb Interneuron Precursor Migration Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Microtubule Polymerization Or Depolymerization DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Negative Regulation Of DNA Damage Checkpoint Histone H3K27ac Reader Activity Globus Pallidus Development Negative Regulation Of Metabolic Process P-TEFb Complex Binding Histone H4 Reader Activity Lipid Digestion Cerebral Cortex Tangential Migration Negative Regulation Of Heterochromatin Formation
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