MBD1 and ECT2

Number of citations of the paper that reports this interaction (PMID 22990118)
7

Data Source:
BioGRID (two hybrid)

		MBD1	ECT2
Gene Name		methyl-CpG binding domain protein 1	epithelial cell transforming 2
Image
Gene Ontology Annotations	Cellular Component	Heterochromatin Nucleus Cytoplasm Nuclear Matrix Nuclear Speck	Nucleus Cytoplasm Cytosol Cell-cell Junction Tight Junction Midbody Nuclear Membrane Cleavage Furrow Intracellular Membrane-bounded Organelle Mitotic Spindle Centralspindlin Complex
	Molecular Function	DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Transcription Corepressor Activity Protein Binding Zinc Ion Binding Methyl-CpG Binding	Signal Transducer Activity Rho Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding Rho GTPase Binding Protein Homodimerization Activity
	Biological Process	Transcription From RNA Polymerase II Promoter Negative Regulation Of Transcription, DNA-templated	Cell Morphogenesis Cytokinesis Small GTPase Mediated Signal Transduction Protein Transport Activation Of Protein Kinase Activity Positive Regulation Of Rho GTPase Activity Positive Regulation Of Cytokinesis Activation Of Rho GTPase Activity Activation Of Rac GTPase Activity Positive Regulation Of Protein Import Into Nucleus Positive Regulation Of Apoptotic Process Positive Regulation Of Cdc42 GTPase Activity Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Neuron Differentiation Regulation Of Protein Kinase Activity Neurotrophin TRK Receptor Signaling Pathway Regulation Of Small GTPase Mediated Signal Transduction Protein Homooligomerization Regulation Of Attachment Of Spindle Microtubules To Kinetochore Cellular Response To Hydrogen Peroxide Tight Junction Assembly Cellular Response To Calcium Ion Cellular Response To Ionizing Radiation Apoptotic Signaling Pathway
Pathways			Rho GTPase cycle Signaling by GPCR GPCR downstream signaling Signalling by NGF Cell death signalling via NRAGE, NRIF and NADE Signaling by Rho GTPases NRAGE signals death through JNK G alpha (12/13) signalling events p75 NTR receptor-mediated signalling
Drugs
Diseases
GWAS		Chronic lymphocytic leukemia ( 20062064)	Obesity-related traits ( 23251661)
Protein-Protein Interactions		24 interactors: APP ATF7IP ATF7IP2 ATXN1L CBX4 CBX5 CHAF1A ECT2 HDAC3 HIPK3 HTT OASL PIAS1 PIAS2 RNF2 SETDB1 SMAD1 SMAD3 SMAD5 SMAD7 SMAD9 SUV39H1 TENM1 ZNF512B	37 interactors: ABR C2orf42 CCDC91 CD19 CDK1 CHST10 COX2 CRIPAK CSTB EIF4A2 EIF5B ERAL1 F2RL2 FANCM GGN ILVBL KLHL20 MBD1 MT2A NOMO1 NPC2 OOSP2 OTUB1 PARD6A PCOLCE PLK1 POMP PSMA6 RACGAP1 RHOG RPS20 SNRNP200 SPATA22 TCEB1 THAP11 UBB VDAC2
Entrez ID		4152	1894
HPRD ID		01133	11860
Ensembl ID		ENSG00000141644	ENSG00000114346
Uniprot IDs		A8K654 B4DI41 B4DUR3 K7ELI2 K7EQZ4 K7ESN0 Q9UIS9	G5E9L8 Q9H8V3
PDB IDs		1D9N 1IG4	3L46
Enriched GO Terms of Interacting Partners?		Transcription, DNA-templated RNA Biosynthetic Process RNA Metabolic Process Gene Expression Regulation Of Gene Expression Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Heterocycle Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Macromolecule Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Nucleobase-containing Compound Metabolic Process Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Biosynthetic Process Regulation Of Cellular Process Ureteric Bud Development Mesonephric Tubule Development Mesonephric Epithelium Development Positive Regulation Of Gene Expression Mesonephros Development Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Transcription, DNA-templated Kidney Epithelium Development Cellular Response To Transforming Growth Factor Beta Stimulus Positive Regulation Of Macromolecule Biosynthetic Process Response To Transforming Growth Factor Beta Cellular Response To Growth Factor Stimulus BMP Signaling Pathway Regulation Of Cell Differentiation Response To Growth Factor Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Protein Sumoylation Cellular Protein Modification Process Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Chromatin Organization Peptidyl-lysine Modification	Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Ligase Activity Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Ubiquitination Cellular Macromolecule Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Positive Regulation Of Protein Ubiquitination Positive Regulation Of Cell Cycle Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of Proteolysis Negative Regulation Of Transferase Activity Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Cellular Protein Catabolic Process DNA Damage Checkpoint Modification-dependent Protein Catabolic Process Mitotic Cell Cycle Checkpoint Proteolysis Involved In Cellular Protein Catabolic Process Viral Process Cellular Protein Catabolic Process Response To Stress Cellular Response To DNA Damage Stimulus Regulation Of Apoptotic Process Protein Catabolic Process Cellular Response To Stress Neurotrophin TRK Receptor Signaling Pathway Regulation Of Cell Death Positive Regulation Of Protein Catabolic Process Negative Regulation Of Mitotic Cell Cycle Positive Regulation Of Cell Cycle Process Neurotrophin Signaling Pathway Regulation Of Cell Cycle Regulation Of Cellular Protein Metabolic Process Cell Cycle Checkpoint Regulation Of Proteolysis Regulation Of Catalytic Activity Mitotic DNA Damage Checkpoint Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Mitotic DNA Integrity Checkpoint Negative Regulation Of Cell Cycle Negative Regulation Of Protein Ubiquitination Mitotic Cell Cycle Phase Transition Cell Cycle Cell Cycle Phase Transition
Tagcloud ?		adipose arousal brown entered euthermic expensive ground hdac4 hdacs hibernating hibernation hp1 ictidomys imparted interbout lined lys23 packing repressors reversal rewarms rose shivering squirrels thermogenesis thirteen torpor tridecemlineatus winter	broader correlate correlates cytoskeleton dbl dbs deregulated encodes exchange family gtpases guanine jun lfc lsc mpk2 nh2 oncogenes panel possess rho sets specificities structurally transformed transforming utilization versions weakly
Tagcloud (Difference) ?		adipose arousal brown entered euthermic expensive ground hdac4 hdacs hibernating hibernation hp1 ictidomys imparted interbout lined lys23 packing repressors reversal rewarms rose shivering squirrels thermogenesis thirteen torpor tridecemlineatus winter	broader correlate correlates cytoskeleton dbl dbs deregulated encodes exchange family gtpases guanine jun lfc lsc mpk2 nh2 oncogenes panel possess rho sets specificities structurally transformed transforming utilization versions weakly
Tagcloud (Intersection) ?