DYRK1A and CEP70

Number of citations of the paper that reports this interaction (PubMedID 35914814)
83

Data Source:
BioGRID (two hybrid)

		DYRK1A	CEP70
Description		dual specificity tyrosine phosphorylation regulated kinase 1A	centrosomal protein 70
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Centrosome Cytosol Cytoskeleton Microtubule Neurofilament Actin Filament Nuclear Speck Axon Dendrite Ribonucleoprotein Complex	Cytoplasm Centrosome Microtubule Organizing Center Cytosol Cytoskeleton
	Molecular Function	Nucleotide Binding Transcription Coactivator Activity Actin Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Binding ATP Binding Cytoskeletal Protein Binding RNA Polymerase II CTD Heptapeptide Repeat Kinase Activity Tubulin Binding Kinase Activity Transferase Activity Identical Protein Binding Tau Protein Binding Tau-protein Kinase Activity Protein Serine Kinase Activity Histone H3T45 Kinase Activity Splicing Factor Binding	Protein Binding Identical Protein Binding Gamma-tubulin Binding
	Biological Process	Regulation Of Alternative MRNA Splicing, Via Spliceosome Double-strand Break Repair Via Homologous Recombination Double-strand Break Repair Via Nonhomologous End Joining Chromatin Remodeling Regulation Of Transcription By RNA Polymerase II Protein Phosphorylation Nervous System Development Circadian Rhythm Peptidyl-tyrosine Phosphorylation Negative Regulation Of Microtubule Polymerization Negative Regulation Of Heterochromatin Formation Positive Regulation Of RNA Splicing Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Positive Regulation Of DNA-templated Transcription Protein Autophosphorylation Negative Regulation Of MRNA Splicing, Via Spliceosome Regulation Of Amyloid-beta Formation Regulation Of Neurofibrillary Tangle Assembly	Cilium Assembly Regulation Of Microtubule Cytoskeleton Organization
Pathways		G0 and Early G1	Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2
Drugs		N-(5-{[(2S)-4-amino-2-(3-chlorophenyl)butanoyl]amino}-1H-indazol-3-yl)benzamide Fostamatinib
Diseases
GWAS		Basophil count ( 32888494) Basophil percentage of white cells ( 32888494) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) HIV-1 replication ( 21364930) Mean corpuscular hemoglobin ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Metabolic syndrome ( 20694148) Neutrophil count ( 32888494) Parkinson's disease ( 32201043) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Stroke ( 30383316) Systolic blood pressure ( 32902719) White blood cell count ( 32888494)	Exhaled carbon monoxide levels in smokers with chronic obstructive pulmonary disease ( 29631575) Femur bone mineral density x serum urate levels interaction ( 34046847) Male-pattern baldness ( 28196072)
Interacting Genes		145 interacting genes: - ABCA2 ABHD12 ADAM19 ADAM22 ADAM23 ADAM9 ADAMTS1 ADAMTS9 AGAP1 AMPH APP ASTN2 ATRN ATRNL1 CACHD1 CCN1 CCNL2 CEP70 CFH CKAP5 CLASRP CLU CREB1 CRIM1 CTNNA1 CYLD DCAF5 DCHS2 DCTD DKK3 DNM1 DNM3 DROSHA DSCAM DSCAML1 DVL3 DYNLL1 EFEMP1 EFEMP2 EIF2B5 ENPP2 ERBB3 ERC1 FAM53C FBN1 FEZ1 FOXO1 GEMIN8 GLI1 GPR37L1 H2BC3 H3C1 H4C1 HMG20A ID2 ITGB8 JCAD KIF1A KPNA4 KPNA6 KPRP LAMB1 LATS2 LEO1 LIN52 LMO3 LRP1B LRP2 LRP4 LTBP3 MAGEH1 MAPT MEGF9 MIGA1 MTA1 MTA3 MYCBP2 MYT1L NAP1L1 NCAPH2 NECAB3 NELL1 NELL2 NPC1 NUCB1 OSBPL1A PCSK6 PEA15 PHYHIP PJA1 PLAUR PLP1 PNISR PRDM4 PRKN PSAP PTOV1 RAPGEF2 RB1 RBL1 RECK RNF169 RNF216 RNF220 RSBN1L SCRIB SF3B1 SMAD2 SNCA SNRNP70 SPRED1 SPRED2 SPRY2 SPTBN1 SRPK2 SRSF1 SRSF10 SRSF4 SRSF5 STAB1 STX1A SULF1 THBS1 TMEFF1 TMEM59 TNFRSF25 TRAF2 TRIM66 TROAP TSPYL2 USP13 USP32 USP34 USP54 USP7 VLDLR VPS54 WIF1 XRCC6 YWHAB YWHAE YWHAG ZBTB11 ZNF365	245 interacting genes: ABT1 AGBL2 AKAP17A ARHGEF3 ARMCX1 ATOSB ATP5PO ATXN7 BARD1 BAZ2B BEX2 BRD1 BRMS1 BRMS1L BRPF1 BYSL C1orf35 C7orf25 C8orf33 CARD9 CAVIN3 CBX8 CCDC187 CCDC85B CDC37 CDC73 CDCA7L CEP57L1 CFAP53 CLPB COIL CWF19L2 DAXX DAZAP2 DDX41 DDX6 DNAJB11 DNTTIP2 DRC4 DVL3 DYRK1A EAF1 EBNA1BP2 EIF3D ELOA ELOA2 EMD EMP1 ENKD1 ERCC3 FAM118B FAM124A FAM133A FAM13C FAM161A FAM161B FAM90A1 GADD45GIP1 GATAD2B GCC1 GEM GLYCTK GPATCH2L GPATCH4 GPX7 GSE1 HAUS1 HDAC4 HDAC6 HIC2 HMGB4 HOXB5 HOXC8 HSPD1 IK INO80B INPP5J IPCEF1 IQCE IQUB ITPKB KANK2 KANSL1 KAT14 KAT5 KAT7 KDM1A KRI1 KRT31 LAMTOR5 LCOR LENG1 LENG8 LIN37 LNX1 MAB21L2 MAGOH MBD3 MCM10 MCRS1 MEST METTL17 MFAP1 MKRN3 MRPL44 NEBL NIPSNAP3A NKAP NKAPD1 NOL12 NOP2 NOP53 NOXA1 NRIP1 NTAQ1 NUSAP1 ODAD4 PAM16 PIBF1 PIMREG PKN1 PLA2G2A PPFIA1 PPIG PPP1R16B PPP1R18 PRKRIP1 PRPF18 PRPF3 PRPF31 PSMA1 PSORS1C2 RASSF10 RBM10 RCOR3 RHPN1 RNF169 RNF6 RPL13 SCNM1 SEC14L1 SERPINH1 SETD5 SFR1 SH2D4A SLU7 SMARCE1 SNRPD2 SNW1 SOD2 SPANXN3 SRGN SSX3 STK25 STMN2 SUV39H1 SUV39H2 SYT17 SYTL4 SYTL5 TAF1D TBC1D22B TBC1D30 TCAF1 TCEA2 TCEANC TEAD4 TLK2 TRAF3IP3 TRIM29 TRIM3 TRIM42 TSFM TSGA10IP TSHZ3 TTLL10 TXLNB TXN2 USP2 UTP11 UTP14A UTP14C UTP25 UTP3 VXN WT1 YJU2 ZBTB16 ZBTB24 ZBTB4 ZBTB47 ZBTB48 ZBTB49 ZBTB8A ZCCHC10 ZFC3H1 ZFHX3 ZFP1 ZFP91 ZGPAT ZNF136 ZNF140 ZNF148 ZNF165 ZNF169 ZNF17 ZNF20 ZNF202 ZNF227 ZNF239 ZNF250 ZNF264 ZNF266 ZNF302 ZNF329 ZNF35 ZNF366 ZNF408 ZNF410 ZNF417 ZNF426 ZNF433 ZNF439 ZNF490 ZNF491 ZNF555 ZNF557 ZNF572 ZNF574 ZNF578 ZNF587 ZNF599 ZNF607 ZNF648 ZNF669 ZNF688 ZNF696 ZNF775 ZNF777 ZNF785 ZNF835 ZNF860 ZSCAN12 ZSCAN21 ZSCAN23
Entrez ID		1859	80321
HPRD ID		09018	16779
Ensembl ID		ENSG00000157540	ENSG00000114107
Uniprot IDs		A0A2R8Y6I6 Q13627	A0A140VJG2 B7Z2D2 Q8NHQ1
PDB IDs		2VX3 2WO6 3ANQ 3ANR 4AZE 4MQ1 4MQ2 4NCT 4YLJ 4YLK 4YLL 4YU2 5A3X 5A4E 5A4L 5A4Q 5A4T 5A54 5AIK 6A1F 6A1G 6EIF 6EIJ 6EIL 6EIP 6EIQ 6EIR 6EIS 6EIV 6EJ4 6LN1 6QU2 6S11 6S14 6S17 6S1B 6S1H 6S1I 6S1J 6T6A 6UIP 6UWY 6YF8 7A4O 7A4R 7A4S 7A4W 7A4Z 7A51 7A52 7A53 7A55 7A5B 7A5D 7A5L 7A5N 7AJ2 7AJ4 7AJ5 7AJ7 7AJ8 7AJA 7AJM 7AJS 7AJV 7AJW 7AJY 7AK2 7AKA 7AKB 7AKE 7AKL 7FHS 7FHT 7O7K 7OY6 7Z5N 7ZH8 8C3G 8C3Q 8C3R 8R8E 8T2H 8YEV
Enriched GO Terms of Interacting Partners?		Regulation Of Developmental Process Regulation Of Cell Differentiation Regulation Of Multicellular Organismal Process Positive Regulation Of Signaling Regulation Of Multicellular Organismal Development Calcium Ion Binding Positive Regulation Of Developmental Process Positive Regulation Of Cell Communication Regulation Of Phosphorus Metabolic Process Positive Regulation Of Signal Transduction Negative Regulation Of Developmental Process Regulation Of Metabolic Process Regulation Of Phosphorylation Negative Regulation Of Signal Transduction Regulation Of Signal Transduction Heparin Binding Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Anatomical Structure Morphogenesis Regulation Of Macromolecule Metabolic Process Regulation Of Signaling Developmental Process Negative Regulation Of Lens Fiber Cell Differentiation Regulation Of Primary Metabolic Process Negative Regulation Of Signaling Negative Regulation Of Cell Communication Regulation Of Protein Metabolic Process Positive Regulation Of Apoptotic Process Positive Regulation Of Metabolic Process Regulation Of Cell Communication Regulation Of Wnt Signaling Pathway Positive Regulation Of Cell Differentiation Integrin Binding Positive Regulation Of Programmed Cell Death Low-density Lipoprotein Particle Receptor Activity Positive Regulation Of Macromolecule Metabolic Process Cell Surface Receptor Signaling Pathway Macromolecule Metabolic Process Regulation Of Protein Localization Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Canonical Wnt Signaling Pathway Extracellular Region Apolipoprotein Binding Negative Regulation Of Wnt Signaling Pathway Positive Regulation Of Protein Metabolic Process Negative Regulation Of Metabolic Process Regulation Of Protein Catabolic Process Positive Regulation Of Phosphate Metabolic Process Response To Growth Factor Neuron Projection Morphogenesis	Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Zinc Ion Binding Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Metabolic Process Nucleus Protein Binding Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process DNA Binding Regulation Of Primary Metabolic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of Macromolecule Metabolic Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Metal Ion Binding Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Regulation Of Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Nucleolus RNA Processing Nuclear Speck Spliceosomal Complex Nucleoplasm RNA Splicing MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Histone Acetyltransferase Complex Chromatin Organization Nuclear Androgen Receptor Binding Protein-RNA Complex Assembly Negative Regulation Of Macromolecule Biosynthetic Process Chromosome Transcription Elongation By RNA Polymerase II RRNA Processing RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Chromatin Remodeling Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process RNA Binding DNA-templated Transcription Elongation RNA Metabolic Process Histone H3-K14 Acetyltransferase Complex MRNA Processing Ribonucleoprotein Complex Biogenesis RRNA Metabolic Process Nucleic Acid Metabolic Process
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