DYRK1A and LIN52

Number of citations of the paper that reports this interaction (PMID 21498571)
27

Data Source:
BioGRID (enzymatic study)

		DYRK1A	LIN52
Gene Name		dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A	lin-52 DREAM MuvB core complex component
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Nuclear Speck Ribonucleoprotein Complex	Nucleoplasm DRM Complex
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Binding ATP Binding Identical Protein Binding Protein Self-association Tau Protein Binding
	Biological Process	Mitotic Cell Cycle Regulation Of Alternative MRNA Splicing, Via Spliceosome Protein Phosphorylation Nervous System Development Circadian Rhythm Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Peptidyl-tyrosine Phosphorylation Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Protein Autophosphorylation Positive Regulation Of Protein Deacetylation	G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Transcription, DNA-templated Regulation Of Cell Cycle
Pathways		G0 and Early G1 Mitotic G1-G1/S phases Cell Cycle, Mitotic	G2/M Transition G0 and Early G1 Mitotic G2-G2/M phases Mitotic G1-G1/S phases Polo-like kinase mediated events Cell Cycle, Mitotic
Drugs
Diseases
GWAS		HIV-1 replication ( 21364930) Metabolic syndrome ( 20694148)
Protein-Protein Interactions		26 interactors: AMPH APP CCNL2 CLASRP CREB1 FOXO1 GLI1 HIST1H2BB HIST1H3A HIST1H4A LATS2 LIN52 LZTS2 PHYHIP PRD RB1 RBL1 SF3B1 SNCA SRSF1 SRSF4 SRSF5 TROAP YWHAB YWHAE YWHAG	1 interactors: DYRK1A
Entrez ID		1859	91750
HPRD ID		09018	18708
Ensembl ID		ENSG00000157540
Uniprot IDs		F8WAP0 Q13627	B3KN83 Q52LA3
PDB IDs		2VX3 2WO6 3ANQ 3ANR 4AZE
Enriched GO Terms of Interacting Partners?		Gene Expression Negative Regulation Of Cellular Metabolic Process Mitotic Cell Cycle Regulation Of Kinase Activity Regulation Of Phosphorus Metabolic Process Nucleobase-containing Compound Metabolic Process RNA Processing MRNA 3'-end Processing Cellular Localization Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Establishment Of Localization In Cell Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Nitrogen Compound Metabolic Process Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Hippo Signaling Regulation Of Phosphorylation Cellular Nitrogen Compound Metabolic Process MRNA Processing Negative Regulation Of Gene Expression RNA 3'-end Processing RNA Metabolic Process Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Nuclear Export Regulation Of Protein Kinase Activity Negative Regulation Of Transcription, DNA-templated Termination Of RNA Polymerase II Transcription Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Protein Dephosphorylation MRNA Metabolic Process Negative Regulation Of Canonical Wnt Signaling Pathway Transcription From RNA Polymerase II Promoter Cellular Response To Growth Factor Stimulus Negative Regulation Of Protein Metabolic Process RNA Splicing Response To Growth Factor Positive Regulation Of Mitochondrion Organization Regulation Of Cell Cycle Regulation Of Protein Metabolic Process Cellular Macromolecular Complex Assembly DNA Replication-dependent Nucleosome Assembly Cellular Response To Fibroblast Growth Factor Stimulus Negative Regulation Of Biosynthetic Process Apoptotic Process Cell Cycle Negative Regulation Of Wnt Signaling Pathway	Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Negative Regulation Of Signal Transduction By P53 Class Mediator Positive Regulation Of Protein Deacetylation Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Regulation Of Alternative MRNA Splicing, Via Spliceosome Regulation Of Signal Transduction By P53 Class Mediator Peptidyl-threonine Phosphorylation Regulation Of Protein Deacetylation Regulation Of MRNA Splicing, Via Spliceosome Regulation Of MRNA Processing Regulation Of RNA Splicing Peptidyl-serine Phosphorylation Regulation Of Response To DNA Damage Stimulus Circadian Rhythm Protein Autophosphorylation Peptidyl-tyrosine Phosphorylation Rhythmic Process
Tagcloud ?		abolished aimed alteration caused colony direct explore finding fluorescent hcc hepatocellular hepg2 mir modulated nfat nfib oncogene overexpression p53 propose regulated reporter suggests suppresses syndrome target targeting tumorigenesis wild
Tagcloud (Difference) ?		abolished aimed alteration caused colony direct explore finding fluorescent hcc hepatocellular hepg2 mir modulated nfat nfib oncogene overexpression p53 propose regulated reporter suggests suppresses syndrome target targeting tumorigenesis wild
Tagcloud (Intersection) ?