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DYRK1A and PRKN
Number of citations of the paper that reports this interaction (PubMedID
25963095
)
0
Data Source:
BioGRID
(affinity chromatography technology, enzymatic study)
DYRK1A
PRKN
Description
dual specificity tyrosine phosphorylation regulated kinase 1A
parkin RBR E3 ubiquitin protein ligase
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Centrosome
Cytosol
Cytoskeleton
Microtubule
Neurofilament
Actin Filament
Nuclear Speck
Axon
Dendrite
Ribonucleoprotein Complex
Golgi Membrane
Ubiquitin Ligase Complex
Nucleus
Cytoplasm
Mitochondrion
Mitochondrial Outer Membrane
Endoplasmic Reticulum
Endoplasmic Reticulum Membrane
Golgi Apparatus
Cytosol
Synaptic Vesicle
Postsynaptic Density
Membrane
Aggresome
Nuclear Speck
SCF Ubiquitin Ligase Complex
Axon
Synaptic Vesicle Membrane
Protein-containing Complex
Cell Projection
Neuron Projection
Neuronal Cell Body
Terminal Bouton
Synapse
Perinuclear Region Of Cytoplasm
Lewy Body
Intracellular Vesicle
Dopaminergic Synapse
Presynapse
Postsynapse
Glutamatergic Synapse
Mitochondrion-derived Vesicle
Parkin-FBXW7-Cul1 Ubiquitin Ligase Complex
Molecular Function
Nucleotide Binding
Transcription Coactivator Activity
Actin Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Protein Serine/threonine/tyrosine Kinase Activity
Protein Tyrosine Kinase Activity
Non-membrane Spanning Protein Tyrosine Kinase Activity
Protein Binding
ATP Binding
Cytoskeletal Protein Binding
RNA Polymerase II CTD Heptapeptide Repeat Kinase Activity
Tubulin Binding
Kinase Activity
Transferase Activity
Identical Protein Binding
Tau Protein Binding
Tau-protein Kinase Activity
Protein Serine Kinase Activity
Histone H3T45 Kinase Activity
Splicing Factor Binding
G Protein-coupled Receptor Binding
Transcription Corepressor Activity
Actin Binding
Ubiquitin-protein Transferase Activity
Protein Binding
Beta-catenin Binding
Zinc Ion Binding
Tubulin Binding
Transferase Activity
SH3 Domain Binding
Enzyme Binding
Kinase Binding
Protein Kinase Binding
PDZ Domain Binding
Hsp70 Protein Binding
Heat Shock Protein Binding
Ubiquitin Conjugating Enzyme Binding
Ubiquitin Protein Ligase Binding
Identical Protein Binding
Histone Deacetylase Binding
Ubiquitin Binding
Phospholipase Binding
Protein-containing Complex Binding
Metal Ion Binding
Protein-folding Chaperone Binding
Ubiquitin Protein Ligase Activity
Cullin Family Protein Binding
Ubiquitin-specific Protease Binding
F-box Domain Binding
Biological Process
Regulation Of Alternative MRNA Splicing, Via Spliceosome
Double-strand Break Repair Via Homologous Recombination
Double-strand Break Repair Via Nonhomologous End Joining
Chromatin Remodeling
Regulation Of Transcription By RNA Polymerase II
Protein Phosphorylation
Nervous System Development
Circadian Rhythm
Peptidyl-tyrosine Phosphorylation
Negative Regulation Of Microtubule Polymerization
Negative Regulation Of Heterochromatin Formation
Positive Regulation Of RNA Splicing
Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator
Positive Regulation Of DNA-templated Transcription
Protein Autophosphorylation
Negative Regulation Of MRNA Splicing, Via Spliceosome
Regulation Of Amyloid-beta Formation
Regulation Of Neurofibrillary Tangle Assembly
Negative Regulation Of Transcription By RNA Polymerase II
Protein Polyubiquitination
Mitochondrial Fission
Autophagy Of Mitochondrion
Mitophagy
Synaptic Transmission, Dopaminergic
Startle Response
Ubiquitin-dependent Protein Catabolic Process
Protein Monoubiquitination
Autophagy
Response To Oxidative Stress
Response To Unfolded Protein
Mitochondrion Organization
Central Nervous System Development
Learning
Locomotory Behavior
Adult Locomotory Behavior
Response To Xenobiotic Stimulus
Positive Regulation Of Catabolic Process
Proteasomal Protein Catabolic Process
Regulation Of Autophagy
Positive Regulation Of Gene Expression
Negative Regulation Of Gene Expression
Positive Regulation Of Mitochondrial Fusion
Negative Regulation Of Mitochondrial Fusion
Regulation Of Mitochondrion Organization
Regulation Of Glucose Metabolic Process
Positive Regulation Of Mitochondrial Membrane Potential
Free Ubiquitin Chain Polymerization
Regulation Of Dopamine Secretion
Response To Muscle Activity
Macroautophagy
Protein Ubiquitination
Protein Deubiquitination
Regulation Of Anatomical Structure Morphogenesis
Protein Catabolic Process
Regulation Of Protein Ubiquitination
Regulation Of Protein Stability
Protein Destabilization
Negative Regulation Of Actin Filament Bundle Assembly
Regulation Of Lipid Transport
Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of Glucokinase Activity
Cellular Response To Oxidative Stress
Cellular Response To Unfolded Protein
Response To Endoplasmic Reticulum Stress
Synaptic Transmission, Glutamatergic
Protein K29-linked Ubiquitination
Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus
ERAD Pathway
Regulation Of Dopamine Metabolic Process
Norepinephrine Metabolic Process
Dopamine Metabolic Process
Regulation Of Apoptotic Process
Positive Regulation Of Apoptotic Process
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of Neuron Apoptotic Process
Mitochondrial Fragmentation Involved In Apoptotic Process
Protein K27-linked Ubiquitination
Host-mediated Suppression Of Viral Genome Replication
Positive Regulation Of Protein Catabolic Process
Positive Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of JNK Cascade
Negative Regulation Of Insulin Secretion
Regulation Of Neurotransmitter Secretion
Modulation Of Chemical Synaptic Transmission
Protein Stabilization
Response To Corticosterone
Positive Regulation Of Neurotransmitter Uptake
Dopamine Uptake Involved In Synaptic Transmission
Mitochondrion Localization
Protein Autoubiquitination
Regulation Of Mitochondrial Membrane Potential
Negative Regulation Of Synaptic Transmission, Glutamatergic
Regulation Of Necroptotic Process
Regulation Of Canonical Wnt Signaling Pathway
Type 2 Mitophagy
Regulation Of Biological Quality
Neuron Cellular Homeostasis
Protein K63-linked Ubiquitination
Protein Localization To Mitochondrion
Aggresome Assembly
Protein K48-linked Ubiquitination
Protein K11-linked Ubiquitination
Cellular Response To Manganese Ion
Regulation Of Primary Metabolic Process
Protein K6-linked Ubiquitination
Negative Regulation Of Canonical Wnt Signaling Pathway
Positive Regulation Of Mitochondrial Fission
Negative Regulation Of Release Of Cytochrome C From Mitochondria
Negative Regulation Of Mitochondrial Fission
Negative Regulation Of Excitatory Postsynaptic Potential
Cellular Response To Toxic Substance
Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels
Mitochondrion To Lysosome Vesicle-mediated Transport
Regulation Protein Catabolic Process At Presynapse
Regulation Of Synaptic Vesicle Endocytosis
Regulation Of Cellular Response To Oxidative Stress
Positive Regulation Of Mitophagy
Positive Regulation Of Proteasomal Protein Catabolic Process
Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway
Negative Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator
Positive Regulation Of Protein Linear Polyubiquitination
Regulation Of Synaptic Vesicle Transport
Regulation Of Protein Targeting To Mitochondrion
Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway
Cellular Response To Dopamine
Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway
Negative Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway
Negative Regulation Of Reactive Oxygen Species Biosynthetic Process
Regulation Of Secretion By Cell
Negative Regulation Of Exosomal Secretion
Positive Regulation Of Dendrite Extension
Negative Regulation Of Spontaneous Neurotransmitter Secretion
Response To Curcumin
Cellular Response To L-glutamine
Cellular Response To Hydrogen Sulfide
Positive Regulation Of Type 2 Mitophagy
Cellular Response To L-glutamate
Positive Regulation Of Retrograde Transport, Endosome To Golgi
Negative Regulation Of Intralumenal Vesicle Formation
Positive Regulation Of Protein Localization To Membrane
Amyloid Fibril Formation
Regulation Of Reactive Oxygen Species Metabolic Process
Negative Regulation Of Reactive Oxygen Species Metabolic Process
Positive Regulation Of ATP Biosynthetic Process
Pathways
G0 and Early G1
PINK1-PRKN Mediated Mitophagy
Regulation of necroptotic cell death
Josephin domain DUBs
Aggrephagy
Amyloid fiber formation
Antigen processing: Ubiquitination & Proteasome degradation
Drugs
N-(5-{[(2S)-4-amino-2-(3-chlorophenyl)butanoyl]amino}-1H-indazol-3-yl)benzamide
Fostamatinib
Diseases
Parkinson's disease (PD)
GWAS
Basophil count (
32888494
)
Basophil percentage of white cells (
32888494
)
Eosinophil count (
32888494
)
Eosinophil percentage of white cells (
32888494
)
HIV-1 replication (
21364930
)
Mean corpuscular hemoglobin (
32888494
)
Mean reticulocyte volume (
32888494
)
Mean spheric corpuscular volume (
32888494
)
Metabolic syndrome (
20694148
)
Neutrophil count (
32888494
)
Parkinson's disease (
32201043
)
Parkinson's disease or first degree relation to individual with Parkinson's disease (
31701892
)
Stroke (
30383316
)
Systolic blood pressure (
32902719
)
White blood cell count (
32888494
)
Triglyceride levels in HIV infection (
33109212
)
Interacting Genes
145 interacting genes:
-
ABCA2
ABHD12
ADAM19
ADAM22
ADAM23
ADAM9
ADAMTS1
ADAMTS9
AGAP1
AMPH
APP
ASTN2
ATRN
ATRNL1
CACHD1
CCN1
CCNL2
CEP70
CFH
CKAP5
CLASRP
CLU
CREB1
CRIM1
CTNNA1
CYLD
DCAF5
DCHS2
DCTD
DKK3
DNM1
DNM3
DROSHA
DSCAM
DSCAML1
DVL3
DYNLL1
EFEMP1
EFEMP2
EIF2B5
ENPP2
ERBB3
ERC1
FAM53C
FBN1
FEZ1
FOXO1
GEMIN8
GLI1
GPR37L1
H2BC3
H3C1
H4C1
HMG20A
ID2
ITGB8
JCAD
KIF1A
KPNA4
KPNA6
KPRP
LAMB1
LATS2
LEO1
LIN52
LMO3
LRP1B
LRP2
LRP4
LTBP3
MAGEH1
MAPT
MEGF9
MIGA1
MTA1
MTA3
MYCBP2
MYT1L
NAP1L1
NCAPH2
NECAB3
NELL1
NELL2
NPC1
NUCB1
OSBPL1A
PCSK6
PEA15
PHYHIP
PJA1
PLAUR
PLP1
PNISR
PRDM4
PRKN
PSAP
PTOV1
RAPGEF2
RB1
RBL1
RECK
RNF169
RNF216
RNF220
RSBN1L
SCRIB
SF3B1
SMAD2
SNCA
SNRNP70
SPRED1
SPRED2
SPRY2
SPTBN1
SRPK2
SRSF1
SRSF10
SRSF4
SRSF5
STAB1
STX1A
SULF1
THBS1
TMEFF1
TMEM59
TNFRSF25
TRAF2
TRIM66
TROAP
TSPYL2
USP13
USP32
USP34
USP54
USP7
VLDLR
VPS54
WIF1
XRCC6
YWHAB
YWHAE
YWHAG
ZBTB11
ZNF365
131 interacting genes:
ADRM1
AIMP2
ATXN3
BAG5
BCL2L1
CASK
CASP1
CASP8
CCND1
CDKN1A
CHPF
COMMD1
COXFA4L2
CRX
CUL1
DLG1
DLX2
DNM1L
DYRK1A
EIF4B
EPS15
FAF1
FAM120A
FBP1
FBXO7
FBXW7
GATA4
GCK
GPR37
GRIN2B
GTPBP4
HDAC6
HEXD
IKBKG
LSG1
MDM2
MEOX1
MEOX2
MFN1
MFN2
MRPL13
MRPL19
MRPL45
MTOR
NEDD8
NEK2
NKRF
NQO1
PA2G4
PAFAH1B2
PDCD2
PHB2
PICK1
PKM
PLK1
PRKAA2
PSMA1
PSMA7
PSMC1
PSMC2
PSMC5
PSMD4
PTPN5
PTTG1
RAB7A
RAC1
RAD1
RAD23A
RALY
RANBP2
RBCK1
REL
RFFL
RGS2
RGS3
RHOT2
SEPTIN4
SEPTIN5
SF3B2
SF3B3
SIM2
SNCA
SNCAIP
SRSF1
STUB1
SUMO1
SYT11
TCF4
TENT5C
TOMM40
TOMM70
TP53
TRIP13
TUBA4A
TUBB
UBASH3A
UBASH3B
UBB
UBC
UBE2A
UBE2B
UBE2C
UBE2D1
UBE2D2
UBE2D4
UBE2E1
UBE2E2
UBE2E3
UBE2G1
UBE2G2
UBE2H
UBE2J1
UBE2J2
UBE2K
UBE2L3
UBE2L6
UBE2M
UBE2N
UBE2O
UBE2R2
UBE2S
UBE2T
UBE2V1
UBE2Z
USP30
USP33
VDAC1
VDR
YWHAH
ZNF622
ZNF746
Entrez ID
1859
5071
HPRD ID
09018
03967
Ensembl ID
ENSG00000157540
ENSG00000185345
Uniprot IDs
A0A2R8Y6I6
Q13627
O60260
X5DR79
PDB IDs
2VX3
2WO6
3ANQ
3ANR
4AZE
4MQ1
4MQ2
4NCT
4YLJ
4YLK
4YLL
4YU2
5A3X
5A4E
5A4L
5A4Q
5A4T
5A54
5AIK
6A1F
6A1G
6EIF
6EIJ
6EIL
6EIP
6EIQ
6EIR
6EIS
6EIV
6EJ4
6LN1
6QU2
6S11
6S14
6S17
6S1B
6S1H
6S1I
6S1J
6T6A
6UIP
6UWY
6YF8
7A4O
7A4R
7A4S
7A4W
7A4Z
7A51
7A52
7A53
7A55
7A5B
7A5D
7A5L
7A5N
7AJ2
7AJ4
7AJ5
7AJ7
7AJ8
7AJA
7AJM
7AJS
7AJV
7AJW
7AJY
7AK2
7AKA
7AKB
7AKE
7AKL
7FHS
7FHT
7O7K
7OY6
7Z5N
7ZH8
8C3G
8C3Q
8C3R
8R8E
8T2H
8YEV
1IYF
2JMO
4BM9
4I1F
4I1H
5C1Z
5C23
5C9V
5N2W
5N38
5TR5
6GLC
6HUE
6N13
8IK6
8IKV
8JWV
8WZN
8WZO
Enriched GO Terms of Interacting Partners
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Regulation Of Developmental Process
Regulation Of Cell Differentiation
Regulation Of Multicellular Organismal Process
Positive Regulation Of Signaling
Regulation Of Multicellular Organismal Development
Calcium Ion Binding
Positive Regulation Of Developmental Process
Positive Regulation Of Cell Communication
Regulation Of Phosphorus Metabolic Process
Positive Regulation Of Signal Transduction
Negative Regulation Of Developmental Process
Regulation Of Metabolic Process
Regulation Of Phosphorylation
Negative Regulation Of Signal Transduction
Regulation Of Signal Transduction
Heparin Binding
Regulation Of Cellular Response To Growth Factor Stimulus
Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Anatomical Structure Morphogenesis
Regulation Of Macromolecule Metabolic Process
Regulation Of Signaling
Developmental Process
Negative Regulation Of Lens Fiber Cell Differentiation
Regulation Of Primary Metabolic Process
Negative Regulation Of Signaling
Negative Regulation Of Cell Communication
Regulation Of Protein Metabolic Process
Positive Regulation Of Apoptotic Process
Positive Regulation Of Metabolic Process
Regulation Of Cell Communication
Regulation Of Wnt Signaling Pathway
Positive Regulation Of Cell Differentiation
Integrin Binding
Positive Regulation Of Programmed Cell Death
Low-density Lipoprotein Particle Receptor Activity
Positive Regulation Of Macromolecule Metabolic Process
Cell Surface Receptor Signaling Pathway
Macromolecule Metabolic Process
Regulation Of Protein Localization
Positive Regulation Of Extrinsic Apoptotic Signaling Pathway
Regulation Of Canonical Wnt Signaling Pathway
Extracellular Region
Apolipoprotein Binding
Negative Regulation Of Wnt Signaling Pathway
Positive Regulation Of Protein Metabolic Process
Negative Regulation Of Metabolic Process
Regulation Of Protein Catabolic Process
Positive Regulation Of Phosphate Metabolic Process
Response To Growth Factor
Neuron Projection Morphogenesis
Ubiquitin Conjugating Enzyme Activity
Ubiquitin Protein Ligase Binding
Protein Polyubiquitination
Modification-dependent Protein Catabolic Process
Proteolysis Involved In Protein Catabolic Process
Post-translational Protein Modification
Ubiquitin-dependent Protein Catabolic Process
Protein Modification By Small Protein Conjugation
Protein Ubiquitination
Macromolecule Catabolic Process
Cytosol
Ubiquitin-protein Transferase Activity
Protein Metabolic Process
Proteolysis
Nucleus
Protein K48-linked Ubiquitination
Catabolic Process
Protein Modification Process
Proteasomal Protein Catabolic Process
Protein Catabolic Process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Macromolecule Metabolic Process
Nucleotide Binding
Regulation Of Protein Metabolic Process
Positive Regulation Of Metabolic Process
Ubiquitin-like Protein Transferase Activity
Regulation Of Metabolic Process
Protein K11-linked Ubiquitination
Positive Regulation Of Protein Metabolic Process
Positive Regulation Of Protein Ubiquitination
Nucleoplasm
Mitochondrial Outer Membrane
Regulation Of Protein Catabolic Process
Protein K63-linked Ubiquitination
Regulation Of Proteolysis
Cytoplasm
Ubiquitin Binding
Positive Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Post-translational Protein Modification
Regulation Of Protein Ubiquitination
Positive Regulation Of Catabolic Process
Regulation Of Proteasomal Protein Catabolic Process
ATP Binding
Regulation Of Post-translational Protein Modification
Regulation Of Mitophagy
Transferase Activity
Protein Binding
Regulation Of Autophagy Of Mitochondrion
Regulation Of Programmed Cell Death
Regulation Of Macromolecule Metabolic Process
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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