DYRK1A and SPRED2

Number of citations of the paper that reports this interaction (PubMedID 35914814)
83

Data Source:
BioGRID (two hybrid)

		DYRK1A	SPRED2
Description		dual specificity tyrosine phosphorylation regulated kinase 1A	sprouty related EVH1 domain containing 2
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Centrosome Cytosol Cytoskeleton Microtubule Neurofilament Actin Filament Nuclear Speck Axon Dendrite Ribonucleoprotein Complex	Cytoplasm Cytosol Plasma Membrane Membrane Transport Vesicle Membrane Cytoplasmic Vesicle
	Molecular Function	Nucleotide Binding Transcription Coactivator Activity Actin Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Binding ATP Binding Cytoskeletal Protein Binding RNA Polymerase II CTD Heptapeptide Repeat Kinase Activity Tubulin Binding Kinase Activity Transferase Activity Identical Protein Binding Tau Protein Binding Tau-protein Kinase Activity Protein Serine Kinase Activity Histone H3T45 Kinase Activity Splicing Factor Binding	Stem Cell Factor Receptor Binding Protein Binding Protein Kinase Binding Protein Serine/threonine Kinase Inhibitor Activity
	Biological Process	Regulation Of Alternative MRNA Splicing, Via Spliceosome Double-strand Break Repair Via Homologous Recombination Double-strand Break Repair Via Nonhomologous End Joining Chromatin Remodeling Regulation Of Transcription By RNA Polymerase II Protein Phosphorylation Nervous System Development Circadian Rhythm Peptidyl-tyrosine Phosphorylation Negative Regulation Of Microtubule Polymerization Negative Regulation Of Heterochromatin Formation Positive Regulation Of RNA Splicing Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Positive Regulation Of DNA-templated Transcription Protein Autophosphorylation Negative Regulation Of MRNA Splicing, Via Spliceosome Regulation Of Amyloid-beta Formation Regulation Of Neurofibrillary Tangle Assembly	Regulation Of Signal Transduction Negative Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of MAPK Cascade Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Negative Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Intracellular Signal Transduction Negative Regulation Of Lens Fiber Cell Differentiation
Pathways		G0 and Early G1	Regulation of RAS by GAPs FGFRL1 modulation of FGFR1 signaling RAS signaling downstream of NF1 loss-of-function variants
Drugs		N-(5-{[(2S)-4-amino-2-(3-chlorophenyl)butanoyl]amino}-1H-indazol-3-yl)benzamide Fostamatinib
Diseases
GWAS		Basophil count ( 32888494) Basophil percentage of white cells ( 32888494) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) HIV-1 replication ( 21364930) Mean corpuscular hemoglobin ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Metabolic syndrome ( 20694148) Neutrophil count ( 32888494) Parkinson's disease ( 32201043) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Stroke ( 30383316) Systolic blood pressure ( 32902719) White blood cell count ( 32888494)	Appendicular lean mass ( 33097823) Basophil count ( 32888494) Basophil percentage of white cells ( 32888494) Body size at age 10 ( 32376654) Celiac disease or Rheumatoid arthritis ( 21383967) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Cognitive decline rate in late mild cognitive impairment ( 26252872) Coronary artery disease ( 33020668) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Gamma glutamyl transferase levels ( 33339817 29403010) Glaucoma (primary open-angle) ( 33627673) Granulocyte percentage of myeloid white cells ( 27863252) Inflammatory bowel disease ( 23128233 27569725) Intraocular pressure ( 29617998) Lung adenocarcinoma ( 28604730) Lung cancer ( 28604730) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Multiple sclerosis ( 31604244) Neutrophil count ( 32888494) Neutrophil percentage of white cells ( 32888494) Psoriasis or type 2 diabetes (trans-disease meta-analysis) ( 33385400) Red blood cell count ( 32888494) Rheumatoid arthritis ( 23143596 24390342 24782177 30423114) Rheumatoid arthritis (ACPA-positive) ( 24532676 23143596) Severe influenza A (H1N1) infection ( 26379185) Sum eosinophil basophil counts ( 27863252) Systemic lupus erythematosus ( 26502338 27399966) Systolic blood pressure ( 31647587) Tonsillectomy ( 27182965 28928442) Total cholesterol levels ( 30275531) White blood cell count ( 32888494 27863252)
Interacting Genes		145 interacting genes: - ABCA2 ABHD12 ADAM19 ADAM22 ADAM23 ADAM9 ADAMTS1 ADAMTS9 AGAP1 AMPH APP ASTN2 ATRN ATRNL1 CACHD1 CCN1 CCNL2 CEP70 CFH CKAP5 CLASRP CLU CREB1 CRIM1 CTNNA1 CYLD DCAF5 DCHS2 DCTD DKK3 DNM1 DNM3 DROSHA DSCAM DSCAML1 DVL3 DYNLL1 EFEMP1 EFEMP2 EIF2B5 ENPP2 ERBB3 ERC1 FAM53C FBN1 FEZ1 FOXO1 GEMIN8 GLI1 GPR37L1 H2BC3 H3C1 H4C1 HMG20A ID2 ITGB8 JCAD KIF1A KPNA4 KPNA6 KPRP LAMB1 LATS2 LEO1 LIN52 LMO3 LRP1B LRP2 LRP4 LTBP3 MAGEH1 MAPT MEGF9 MIGA1 MTA1 MTA3 MYCBP2 MYT1L NAP1L1 NCAPH2 NECAB3 NELL1 NELL2 NPC1 NUCB1 OSBPL1A PCSK6 PEA15 PHYHIP PJA1 PLAUR PLP1 PNISR PRDM4 PRKN PSAP PTOV1 RAPGEF2 RB1 RBL1 RECK RNF169 RNF216 RNF220 RSBN1L SCRIB SF3B1 SMAD2 SNCA SNRNP70 SPRED1 SPRED2 SPRY2 SPTBN1 SRPK2 SRSF1 SRSF10 SRSF4 SRSF5 STAB1 STX1A SULF1 THBS1 TMEFF1 TMEM59 TNFRSF25 TRAF2 TRIM66 TROAP TSPYL2 USP13 USP32 USP34 USP54 USP7 VLDLR VPS54 WIF1 XRCC6 YWHAB YWHAE YWHAG ZBTB11 ZNF365	30 interacting genes: AQP1 CTSD DYRK1A KCNIP1 KIT KPRP KRTAP12-2 KRTAP2-3 KRTAP2-4 LCE1C LCE2B LCE5A MDFI MTDH MYO15B NCS1 NDUFB7 QARS1 RBM48 RHOA RPS6KA6 SPG21 TOP3B TSNAX VSNL1 ZNF250 ZNF414 ZNF417 ZNF575 ZNF837
Entrez ID		1859	200734
HPRD ID		09018	18100
Ensembl ID		ENSG00000157540	ENSG00000198369
Uniprot IDs		A0A2R8Y6I6 Q13627	B3KPL5 Q7Z698
PDB IDs		2VX3 2WO6 3ANQ 3ANR 4AZE 4MQ1 4MQ2 4NCT 4YLJ 4YLK 4YLL 4YU2 5A3X 5A4E 5A4L 5A4Q 5A4T 5A54 5AIK 6A1F 6A1G 6EIF 6EIJ 6EIL 6EIP 6EIQ 6EIR 6EIS 6EIV 6EJ4 6LN1 6QU2 6S11 6S14 6S17 6S1B 6S1H 6S1I 6S1J 6T6A 6UIP 6UWY 6YF8 7A4O 7A4R 7A4S 7A4W 7A4Z 7A51 7A52 7A53 7A55 7A5B 7A5D 7A5L 7A5N 7AJ2 7AJ4 7AJ5 7AJ7 7AJ8 7AJA 7AJM 7AJS 7AJV 7AJW 7AJY 7AK2 7AKA 7AKB 7AKE 7AKL 7FHS 7FHT 7O7K 7OY6 7Z5N 7ZH8 8C3G 8C3Q 8C3R 8R8E 8T2H 8YEV	2JP2 8EQ5
Enriched GO Terms of Interacting Partners?		Regulation Of Developmental Process Regulation Of Cell Differentiation Regulation Of Multicellular Organismal Process Positive Regulation Of Signaling Regulation Of Multicellular Organismal Development Calcium Ion Binding Positive Regulation Of Developmental Process Positive Regulation Of Cell Communication Regulation Of Phosphorus Metabolic Process Positive Regulation Of Signal Transduction Negative Regulation Of Developmental Process Regulation Of Metabolic Process Regulation Of Phosphorylation Negative Regulation Of Signal Transduction Regulation Of Signal Transduction Heparin Binding Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Anatomical Structure Morphogenesis Regulation Of Macromolecule Metabolic Process Regulation Of Signaling Developmental Process Negative Regulation Of Lens Fiber Cell Differentiation Regulation Of Primary Metabolic Process Negative Regulation Of Signaling Negative Regulation Of Cell Communication Regulation Of Protein Metabolic Process Positive Regulation Of Apoptotic Process Positive Regulation Of Metabolic Process Regulation Of Cell Communication Regulation Of Wnt Signaling Pathway Positive Regulation Of Cell Differentiation Integrin Binding Positive Regulation Of Programmed Cell Death Low-density Lipoprotein Particle Receptor Activity Positive Regulation Of Macromolecule Metabolic Process Cell Surface Receptor Signaling Pathway Macromolecule Metabolic Process Regulation Of Protein Localization Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Canonical Wnt Signaling Pathway Extracellular Region Apolipoprotein Binding Negative Regulation Of Wnt Signaling Pathway Positive Regulation Of Protein Metabolic Process Negative Regulation Of Metabolic Process Regulation Of Protein Catabolic Process Positive Regulation Of Phosphate Metabolic Process Response To Growth Factor Neuron Projection Morphogenesis
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