DYRK1A and HIST1H2BB

Number of citations of the paper that reports this interaction (PMID 10644696)
49

Data Source:
BioGRID (enzymatic study)

		DYRK1A	HIST1H2BB
Gene Name		dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A	histone cluster 1, H2bb
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Nuclear Speck Ribonucleoprotein Complex	Nucleosome Nucleus Nucleoplasm
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Binding ATP Binding Identical Protein Binding Protein Self-association Tau Protein Binding	DNA Binding Protein Binding Protein Heterodimerization Activity
	Biological Process	Mitotic Cell Cycle Regulation Of Alternative MRNA Splicing, Via Spliceosome Protein Phosphorylation Nervous System Development Circadian Rhythm Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Peptidyl-tyrosine Phosphorylation Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Protein Autophosphorylation Positive Regulation Of Protein Deacetylation	Chromatin Organization Nucleosome Assembly
Pathways		G0 and Early G1 Mitotic G1-G1/S phases Cell Cycle, Mitotic	RNA Polymerase I Chain Elongation RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription Mitotic Prophase Regulatory RNA pathways RNA Polymerase I Promoter Clearance Deposition of new CENPA-containing nucleosomes at the centromere Cellular Senescence Signaling by Wnt HATs acetylate histones M Phase Amyloids NoRC negatively regulates rRNA expression Packaging Of Telomere Ends Telomere Maintenance Nucleosome assembly RNF mutants show enhanced WNT signaling and proliferation XAV939 inhibits tankyrase, stabilizing AXIN DNA methylation Transcriptional regulation by small RNAs Meiotic recombination DNA Damage/Telomere Stress Induced Senescence Chromosome Maintenance Chromatin organization HDACs deacetylate histones misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling RNA Polymerase I Transcription formation of the beta-catenin:TCF transactivating complex Meiotic synapsis Epigenetic regulation of gene expression Senescence-Associated Secretory Phenotype (SASP) Negative epigenetic regulation of rRNA expression PRC2 methylates histones and DNA Cell Cycle, Mitotic Chromatin modifying enzymes Oxidative Stress Induced Senescence TCF dependent signaling in response to WNT RNA Polymerase I Promoter Opening SIRT1 negatively regulates rRNA Expression Signaling by WNT in cancer Condensation of Prophase Chromosomes
Drugs
Diseases
GWAS		HIV-1 replication ( 21364930) Metabolic syndrome ( 20694148)
Protein-Protein Interactions		26 interactors: AMPH APP CCNL2 CLASRP CREB1 FOXO1 GLI1 HIST1H2BB HIST1H3A HIST1H4A LATS2 LIN52 LZTS2 PHYHIP PRD RB1 RBL1 SF3B1 SNCA SRSF1 SRSF4 SRSF5 TROAP YWHAB YWHAE YWHAG	12 interactors: APP CDK1 CDK2 CREBBP DYRK1A EID1 EP300 ERCC6 KAT2B RNF20 UHRF1 USP16
Entrez ID		1859	3018
HPRD ID		09018	07536
Ensembl ID		ENSG00000157540	ENSG00000196226
Uniprot IDs		F8WAP0 Q13627	P33778
PDB IDs		2VX3 2WO6 3ANQ 3ANR 4AZE
Enriched GO Terms of Interacting Partners?		Gene Expression Negative Regulation Of Cellular Metabolic Process Mitotic Cell Cycle Regulation Of Kinase Activity Regulation Of Phosphorus Metabolic Process Nucleobase-containing Compound Metabolic Process RNA Processing MRNA 3'-end Processing Cellular Localization Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Establishment Of Localization In Cell Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Nitrogen Compound Metabolic Process Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Hippo Signaling Regulation Of Phosphorylation Cellular Nitrogen Compound Metabolic Process MRNA Processing Negative Regulation Of Gene Expression RNA 3'-end Processing RNA Metabolic Process Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Nuclear Export Regulation Of Protein Kinase Activity Negative Regulation Of Transcription, DNA-templated Termination Of RNA Polymerase II Transcription Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Protein Dephosphorylation MRNA Metabolic Process Negative Regulation Of Canonical Wnt Signaling Pathway Transcription From RNA Polymerase II Promoter Cellular Response To Growth Factor Stimulus Negative Regulation Of Protein Metabolic Process RNA Splicing Response To Growth Factor Positive Regulation Of Mitochondrion Organization Regulation Of Cell Cycle Regulation Of Protein Metabolic Process Cellular Macromolecular Complex Assembly DNA Replication-dependent Nucleosome Assembly Cellular Response To Fibroblast Growth Factor Stimulus Negative Regulation Of Biosynthetic Process Apoptotic Process Cell Cycle Negative Regulation Of Wnt Signaling Pathway	Histone Modification Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Chromatin Modification Positive Regulation Of Gene Expression N-terminal Peptidyl-lysine Acetylation Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Chromatin Organization Positive Regulation Of Transcription, DNA-templated Regulation Of RNA Metabolic Process Chromosome Organization Positive Regulation Of Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process N-terminal Protein Amino Acid Acetylation Cell Cycle Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Cellular Protein Modification Process N-terminal Protein Amino Acid Modification Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Notch Signaling Pathway Positive Regulation Of Protein Metabolic Process Regulation Of Metabolic Process Cellular Response To DNA Damage Stimulus Cellular Protein Metabolic Process Cellular Response To Stress Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Nucleobase-containing Compound Metabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Protein Catabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Protein Catabolic Process Rhythmic Process Nitrogen Compound Metabolic Process Protein Metabolic Process Mitotic Cell Cycle Histone Acetylation G2/M Transition Of Mitotic Cell Cycle Internal Peptidyl-lysine Acetylation
Tagcloud ?		abolished aimed alteration caused colony direct explore finding fluorescent hcc hepatocellular hepg2 mir modulated nfat nfib oncogene overexpression p53 propose regulated reporter suggests suppresses syndrome target targeting tumorigenesis wild
Tagcloud (Difference) ?		abolished aimed alteration caused colony direct explore finding fluorescent hcc hepatocellular hepg2 mir modulated nfat nfib oncogene overexpression p53 propose regulated reporter suggests suppresses syndrome target targeting tumorigenesis wild
Tagcloud (Intersection) ?