DLX2 and DGCR6

Number of citations of the paper that reports this interaction (PubMedID 24722188)
69

Data Source:
BioGRID (two hybrid)

		DLX2	DGCR6
Description		distal-less homeobox 2	DiGeorge syndrome critical region gene 6
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus	Nucleus Extracellular Matrix
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Single-stranded RNA Binding Protein Binding Sequence-specific Double-stranded DNA Binding	Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Notch Signaling Pathway Brain Development Proximal/distal Pattern Formation Neuroblast Differentiation Subpallium Development Hippocampus Development Olfactory Bulb Development Forebrain Neuron Differentiation Cerebral Cortex GABAergic Interneuron Differentiation Cerebral Cortex GABAergic Interneuron Fate Commitment Cell Differentiation Odontogenesis Of Dentin-containing Tooth Positive Regulation Of Cell Differentiation Negative Regulation Of Notch Signaling Pathway Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Photoreceptor Cell Differentiation Embryonic Cranial Skeleton Morphogenesis Embryonic Skeletal System Development Oligodendrocyte Differentiation Negative Regulation Of Oligodendrocyte Differentiation Branching Morphogenesis Of A Nerve Cartilage Development GABAergic Neuron Differentiation Positive Regulation Of Amacrine Cell Differentiation	Cell Adhesion Animal Organ Morphogenesis
Pathways
Drugs
Diseases
GWAS		Breast cancer ( 23535729) Food allergy ( 29030101) Peanut allergy ( 29030101)	High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Metabolite levels ( 23823483) Plasma free amino acid levels ( 30659259) Plasma free amino acid levels (adjusted for twenty other PFAAs) ( 30659259)
Interacting Genes		14 interacting genes: AVP DGCR6 DIP2A DLX5 GRN HOXC8 MSX1 MSX2 MVP NCOA2 PIK3R1 PRKN TSPOAP1 XRCC6	67 interacting genes: ADAMTSL4 AGTRAP AKAP8L APP ARNT2 C1orf94 C3orf62 CBLL1 CBY2 CCDC33 CEP126 CTBP1 DEUP1 DLGAP2 DLX2 DNPEP DOCK8 EFEMP2 EFHC2 ENKD1 ESS2 FBF1 FH FTCD GOLGA2 GSE1 HGS HOMEZ IHO1 IKZF3 INIP KLHL12 KRTAP12-2 LZTS2 MBIP MEIS2 MEOX2 MIA2 MID2 MIPOL1 NAB2 NECAB2 NOTCH2NLA NQO2 NUP54 NUP62 PDLIM7 PRDM14 RABGEF1 REL RFX6 RIMBP3 SPRY2 SS18L1 TCF12 TCF4 TFIP11 TLE5 TRAF1 TRAF2 TRIM27 TUBGCP4 VCP ZBED1 ZC4H2 ZNF398 ZNF446
Entrez ID		1746	8214
HPRD ID		00527	03177
Ensembl ID		ENSG00000115844	ENSG00000183628
Uniprot IDs		Q07687 Q53QU7 X5D7D8	Q14129 X5D7D2
PDB IDs
Enriched GO Terms of Interacting Partners?		Bone Morphogenesis Embryonic Nail Plate Morphogenesis Cell Surface Receptor Signaling Pathway Involved In Heart Development Activation Of Meiosis Positive Regulation Of Mesenchymal Cell Apoptotic Process Locomotory Behavior Regulation Of Primary Metabolic Process Negative Regulation Of Programmed Cell Death Regulation Of Macromolecule Metabolic Process Negative Regulation Of Apoptotic Process Transcription Cis-regulatory Region Binding Embryonic Limb Morphogenesis Animal Organ Morphogenesis BMP Signaling Pathway Transcription Regulator Complex Protein Stabilization Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Mammary Gland Epithelium Development Mesenchymal Cell Apoptotic Process Negative Regulation Of Metabolic Process Positive Regulation Of Meiotic Nuclear Division Cardiac Conduction System Development Limb Morphogenesis Response To Salt Stress Cellular Homeostasis Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Metabolic Process Regulation Of Cell Population Proliferation Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Protein Stability Positive Regulation Of Meiotic Cell Cycle Regulation Of Transcription By RNA Polymerase II Embryonic Hindlimb Morphogenesis Cardiac Epithelial To Mesenchymal Transition Positive Regulation Of Transcription By RNA Polymerase II Face Morphogenesis Anterior/posterior Pattern Specification Embryonic Forelimb Morphogenesis Negative Regulation Of DNA-templated Transcription Negative Regulation Of Macromolecule Metabolic Process Regulation Of Meiotic Nuclear Division Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Metabolic Process Regulation Of Cell Communication Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Positive Regulation Of Developmental Process Hindlimb Morphogenesis Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Negative Regulation Of Actin Filament Bundle Assembly	Identical Protein Binding Protein Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Neuron Differentiation PTB Domain Binding Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Microtubule-based Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Ras Protein Signal Transduction Regulation Of Primary Metabolic Process Regulation Of RNA Metabolic Process Positive Regulation Of RNA Metabolic Process Microtubule Cytoskeleton Organization Involved In Mitosis Positive Regulation Of Macromolecule Metabolic Process Nuclear Pore Central Transport Channel Regulation Of Transcription By RNA Polymerase II Microtubule Spindle Pole Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Biosynthetic Process Thioesterase Binding Positive Regulation Of Metabolic Process DNA Binding Regulation Of Neuron Differentiation Chromatin DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of Ras Protein Signal Transduction Notch Signaling Pathway Positive Regulation Of Transcription By RNA Polymerase II
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