DLX2 and DLX5

Number of citations of the paper that reports this interaction (PubMedID 9111364)
41

Data Source:
BioGRID (pull down, pull down)

		DLX2	DLX5
Description		distal-less homeobox 2	distal-less homeobox 5
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus	Chromatin Nucleus Cytoplasm
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Single-stranded RNA Binding Protein Binding Sequence-specific Double-stranded DNA Binding	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding HMG Box Domain Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Notch Signaling Pathway Brain Development Proximal/distal Pattern Formation Neuroblast Differentiation Subpallium Development Hippocampus Development Olfactory Bulb Development Forebrain Neuron Differentiation Cerebral Cortex GABAergic Interneuron Differentiation Cerebral Cortex GABAergic Interneuron Fate Commitment Cell Differentiation Odontogenesis Of Dentin-containing Tooth Positive Regulation Of Cell Differentiation Negative Regulation Of Notch Signaling Pathway Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Photoreceptor Cell Differentiation Embryonic Cranial Skeleton Morphogenesis Embryonic Skeletal System Development Oligodendrocyte Differentiation Negative Regulation Of Oligodendrocyte Differentiation Branching Morphogenesis Of A Nerve Cartilage Development GABAergic Neuron Differentiation Positive Regulation Of Amacrine Cell Differentiation	Skeletal System Development Ossification Osteoblast Differentiation Endochondral Ossification Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Nervous System Development Axonogenesis Axon Guidance Cell Population Proliferation Positive Regulation Of Gene Expression Olfactory Bulb Interneuron Differentiation Cell Differentiation Embryonic Limb Morphogenesis BMP Signaling Pathway Epithelial Cell Differentiation Inner Ear Morphogenesis Ear Development Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Anatomical Structure Formation Involved In Morphogenesis Embryonic Skeletal System Development Positive Regulation Of Epithelial Cell Proliferation Roof Of Mouth Development Olfactory Pit Development Head Development Face Morphogenesis Bone Morphogenesis Positive Regulation Of Canonical Wnt Signaling Pathway Interneuron Axon Guidance
Pathways			Regulation of RUNX2 expression and activity Specification of the neural plate border Developmental Lineage of Mammary Stem Cells
Drugs
Diseases
GWAS		Breast cancer ( 23535729) Food allergy ( 29030101) Peanut allergy ( 29030101)	Heel bone mineral density ( 28869591 30598549) Liver enzyme levels (alkaline phosphatase) ( 33972514) Morning vs. evening chronotype ( 26835600)
Interacting Genes		14 interacting genes: AVP DGCR6 DIP2A DLX5 GRN HOXC8 MSX1 MSX2 MVP NCOA2 PIK3R1 PRKN TSPOAP1 XRCC6	9 interacting genes: DLX2 HOXC8 MAGED1 MSX1 MSX2 NCOA2 SOX10 SOX8 SPEN
Entrez ID		1746	1749
HPRD ID		00527	02492
Ensembl ID		ENSG00000115844	ENSG00000105880
Uniprot IDs		Q07687 Q53QU7 X5D7D8	P56178 Q53Y73
PDB IDs			2DJN 4RDU
Enriched GO Terms of Interacting Partners?		Bone Morphogenesis Embryonic Nail Plate Morphogenesis Cell Surface Receptor Signaling Pathway Involved In Heart Development Activation Of Meiosis Positive Regulation Of Mesenchymal Cell Apoptotic Process Locomotory Behavior Regulation Of Primary Metabolic Process Negative Regulation Of Programmed Cell Death Regulation Of Macromolecule Metabolic Process Negative Regulation Of Apoptotic Process Transcription Cis-regulatory Region Binding Embryonic Limb Morphogenesis Animal Organ Morphogenesis BMP Signaling Pathway Transcription Regulator Complex Protein Stabilization Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Mammary Gland Epithelium Development Mesenchymal Cell Apoptotic Process Negative Regulation Of Metabolic Process Positive Regulation Of Meiotic Nuclear Division Cardiac Conduction System Development Limb Morphogenesis Response To Salt Stress Cellular Homeostasis Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Metabolic Process Regulation Of Cell Population Proliferation Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Protein Stability Positive Regulation Of Meiotic Cell Cycle Regulation Of Transcription By RNA Polymerase II Embryonic Hindlimb Morphogenesis Cardiac Epithelial To Mesenchymal Transition Positive Regulation Of Transcription By RNA Polymerase II Face Morphogenesis Anterior/posterior Pattern Specification Embryonic Forelimb Morphogenesis Negative Regulation Of DNA-templated Transcription Negative Regulation Of Macromolecule Metabolic Process Regulation Of Meiotic Nuclear Division Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Metabolic Process Regulation Of Cell Communication Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Positive Regulation Of Developmental Process Hindlimb Morphogenesis Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Negative Regulation Of Actin Filament Bundle Assembly	Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Chromatin Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Developmental Process Negative Regulation Of Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Sequence-specific Double-stranded DNA Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Positive Regulation Of Mesenchymal Cell Apoptotic Process Morphogenesis Of A Branching Structure Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Developmental Process Oligodendrocyte Differentiation Embryonic Nail Plate Morphogenesis Cell Surface Receptor Signaling Pathway Involved In Heart Development Positive Regulation Of Multicellular Organismal Process Activation Of Meiosis Animal Organ Morphogenesis Negative Regulation Of Photoreceptor Cell Differentiation DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription Regulator Complex Regulation Of Multicellular Organismal Process Transcription Cis-regulatory Region Binding Regionalization Regulation Of Gene Expression Regulation Of Animal Organ Morphogenesis Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Cell Differentiation DNA Binding Regulation Of Primary Metabolic Process Mammary Gland Epithelium Development Odontogenesis Mesenchymal Cell Apoptotic Process Enteric Nervous System Development Regulation Of Gliogenesis Cartilage Development Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Glial Cell Differentiation Regulation Of Multicellular Organismal Development RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Stem Cell Differentiation Regulation Of Neurogenesis
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