DLX2 and AVP

Number of citations of the paper that reports this interaction (PubMedID 24722188)
69

Data Source:
BioGRID (two hybrid)

		DLX2	AVP
Description		distal-less homeobox 2	arginine vasopressin
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus	Extracellular Region Extracellular Space Cytosol Secretory Granule Dendrite Clathrin-coated Endocytic Vesicle Membrane Neuronal Dense Core Vesicle
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Single-stranded RNA Binding Protein Binding Sequence-specific Double-stranded DNA Binding	Protein Kinase Activity Signaling Receptor Binding Hormone Activity Neuropeptide Hormone Activity Neurohypophyseal Hormone Activity Protein Binding V1A Vasopressin Receptor Binding V1B Vasopressin Receptor Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Notch Signaling Pathway Brain Development Proximal/distal Pattern Formation Neuroblast Differentiation Subpallium Development Hippocampus Development Olfactory Bulb Development Forebrain Neuron Differentiation Cerebral Cortex GABAergic Interneuron Differentiation Cerebral Cortex GABAergic Interneuron Fate Commitment Cell Differentiation Odontogenesis Of Dentin-containing Tooth Positive Regulation Of Cell Differentiation Negative Regulation Of Notch Signaling Pathway Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Photoreceptor Cell Differentiation Embryonic Cranial Skeleton Morphogenesis Embryonic Skeletal System Development Oligodendrocyte Differentiation Negative Regulation Of Oligodendrocyte Differentiation Branching Morphogenesis Of A Nerve Cartilage Development GABAergic Neuron Differentiation Positive Regulation Of Amacrine Cell Differentiation	Maternal Aggressive Behavior Positive Regulation Of Systemic Arterial Blood Pressure Generation Of Precursor Metabolites And Energy Water Transport Signal Transduction Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Cell-cell Signaling Negative Regulation Of Female Receptivity Grooming Behavior Locomotory Behavior Positive Regulation Of Cell Population Proliferation Response To Xenobiotic Stimulus Response To Salt Stress Positive Regulation Of Gene Expression Positive Regulation Of Glutamate Secretion Positive Regulation Of Cell Growth Positive Regulation Of Prostaglandin Biosynthetic Process Positive Regulation Of Cellular PH Reduction Multicellular Organismal Response To Stress Response To Testosterone Response To Nicotine Social Behavior Intracellular Signal Transduction Vasoconstriction Maternal Behavior Negative Regulation Of Apoptotic Process Response To Ethanol Positive Regulation Of Vasoconstriction Symbiont Entry Into Host Cell Multicellular Organismal-level Water Homeostasis Response To Electrical Stimulus Negative Regulation Of Transmission Of Nerve Impulse Renal Water Absorption Blood Vessel Diameter Maintenance Response To Peptide Response To 2,3,7,8-tetrachlorodibenzodioxine Response To Nerve Growth Factor
Pathways			BMAL1:CLOCK,NPAS2 activates circadian expression Vasopressin-like receptors G alpha (q) signalling events G alpha (s) signalling events Vasopressin regulates renal water homeostasis via Aquaporins Defective AVP does not bind AVPR1A,B and causes neurohypophyseal diabetes insipidus (NDI) Organic anion transport by SLCO transporters Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis Defective AVP does not bind AVPR2 and causes neurohypophyseal diabetes insipidus (NDI)
Drugs
Diseases			Neurohypophyseal diabetes insipidus (NPDI); Central Diabetes Insipidus
GWAS		Breast cancer ( 23535729) Food allergy ( 29030101) Peanut allergy ( 29030101)
Interacting Genes		14 interacting genes: AVP DGCR6 DIP2A DLX5 GRN HOXC8 MSX1 MSX2 MVP NCOA2 PIK3R1 PRKN TSPOAP1 XRCC6	9 interacting genes: AVPR1A AVPR1B AVPR2 CRYAB DLX2 KMT2A OXTR PRKAB2 TXNDC17
Entrez ID		1746	551
HPRD ID		00527	01891
Ensembl ID		ENSG00000115844	ENSG00000101200
Uniprot IDs		Q07687 Q53QU7 X5D7D8	P01185 X5DQP6
PDB IDs			7BB6 7BB7 7DW9 7KH0 7R0C
Enriched GO Terms of Interacting Partners?		Bone Morphogenesis Embryonic Nail Plate Morphogenesis Cell Surface Receptor Signaling Pathway Involved In Heart Development Activation Of Meiosis Positive Regulation Of Mesenchymal Cell Apoptotic Process Locomotory Behavior Regulation Of Primary Metabolic Process Negative Regulation Of Programmed Cell Death Regulation Of Macromolecule Metabolic Process Negative Regulation Of Apoptotic Process Transcription Cis-regulatory Region Binding Embryonic Limb Morphogenesis Animal Organ Morphogenesis BMP Signaling Pathway Transcription Regulator Complex Protein Stabilization Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Mammary Gland Epithelium Development Mesenchymal Cell Apoptotic Process Negative Regulation Of Metabolic Process Positive Regulation Of Meiotic Nuclear Division Cardiac Conduction System Development Limb Morphogenesis Response To Salt Stress Cellular Homeostasis Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Metabolic Process Regulation Of Cell Population Proliferation Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Protein Stability Positive Regulation Of Meiotic Cell Cycle Regulation Of Transcription By RNA Polymerase II Embryonic Hindlimb Morphogenesis Cardiac Epithelial To Mesenchymal Transition Positive Regulation Of Transcription By RNA Polymerase II Face Morphogenesis Anterior/posterior Pattern Specification Embryonic Forelimb Morphogenesis Negative Regulation Of DNA-templated Transcription Negative Regulation Of Macromolecule Metabolic Process Regulation Of Meiotic Nuclear Division Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Metabolic Process Regulation Of Cell Communication Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Positive Regulation Of Developmental Process Hindlimb Morphogenesis Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Negative Regulation Of Actin Filament Bundle Assembly	Regulation Of Systemic Arterial Blood Pressure By Vasopressin Vasopressin Receptor Activity Regulation Of Systemic Arterial Blood Pressure Mediated By A Chemical Signal Positive Regulation Of Vasoconstriction Regulation Of Systemic Arterial Blood Pressure Regulation Of Vasoconstriction Positive Regulation Of Blood Pressure Blood Vessel Diameter Maintenance Regulation Of Tube Size Regulation Of Blood Pressure Regulation Of Blood Circulation Vascular Process In Circulatory System Circulatory System Process Cellular Response To Hormone Stimulus G Protein-coupled Receptor Activity System Process Positive Regulation Of Systemic Arterial Blood Pressure Telencephalon Development Signal Transduction Regulation Of System Process G Protein-coupled Peptide Receptor Activity Response To Hormone Protein Kinase C Binding Positive Regulation Of Metabolic Process G Protein-coupled Receptor Signaling Pathway Renal Water Retention Oxytocin Receptor Activity Endocytic Vesicle Regulation Of Biological Quality Transport Across Blood-brain Barrier Positive Regulation Of Multicellular Organismal Process V1A Vasopressin Receptor Binding Cerebral Cortex GABAergic Interneuron Fate Commitment Negative Regulation Of DNA Methylation-dependent Heterochromatin Formation Protein-cysteine Methyltransferase Activity Positive Regulation Of Cold-induced Thermogenesis Regulation Of Multicellular Organismal Process Regulation Of Metabolic Process Cellular Response To Water Deprivation Response To Water Deprivation Sperm Ejaculation Negative Regulation Of Female Receptivity Maternal Aggressive Behavior Subpallium Development Positive Regulation Of Amacrine Cell Differentiation Cerebral Cortex GABAergic Interneuron Differentiation Protein-disulfide Reductase [NAD(P)H] Activity Positive Regulation Of Cellular PH Reduction Positive Regulation Of Arachidonate Secretion Negative Regulation Of Urine Volume
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