DLX2 and AVP

Number of citations of the paper that reports this interaction (PMID 24722188)
1

Data Source:
BioGRID (two hybrid)

		DLX2	AVP
Gene Name		distal-less homeobox 2	arginine vasopressin
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus	Extracellular Region Extracellular Space Cytosol Secretory Granule Dendrite
	Molecular Function	Chromatin Binding Sequence-specific DNA Binding Transcription Factor Activity Single-stranded RNA Binding Sequence-specific DNA Binding	Protein Kinase Activity Signal Transducer Activity Receptor Binding Neuropeptide Hormone Activity Neurohypophyseal Hormone Activity V1A Vasopressin Receptor Binding V1B Vasopressin Receptor Binding Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Brain Development Proximal/distal Pattern Formation Subpallium Development Hippocampus Development Olfactory Bulb Development Regulation Of Transcription From RNA Polymerase II Promoter Involved In Forebrain Neuron Fate Commitment Cerebral Cortex GABAergic Interneuron Fate Commitment Odontogenesis Of Dentin-containing Tooth Negative Regulation Of Notch Signaling Pathway Positive Regulation Of Transcription From RNA Polymerase II Promoter Embryonic Cranial Skeleton Morphogenesis Negative Regulation Of Oligodendrocyte Differentiation Branching Morphogenesis Of A Nerve Cartilage Development	Maternal Aggressive Behavior Positive Regulation Of Systemic Arterial Blood Pressure Renal Water Homeostasis Generation Of Precursor Metabolites And Energy Protein Phosphorylation Water Transport Signal Transduction Positive Regulation Of Cytosolic Calcium Ion Concentration Cell-cell Signaling Negative Regulation Of Female Receptivity Circadian Rhythm Grooming Behavior Locomotory Behavior Positive Regulation Of Cell Proliferation Positive Regulation Of Gene Expression Positive Regulation Of Glutamate Secretion Positive Regulation Of Cell Growth Positive Regulation Of CAMP Biosynthetic Process Positive Regulation Of Prostaglandin Biosynthetic Process Positive Regulation Of Cellular PH Reduction Positive Regulation Of Peptidyl-serine Phosphorylation Response To Testosterone Response To Nicotine Social Behavior Regulation Of Renal Sodium Excretion Vasoconstriction Hyperosmotic Salinity Response Maternal Behavior Negative Regulation Of Apoptotic Process Penile Erection Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Sodium-independent Organic Anion Transport Response To Ethanol Positive Regulation Of Vasoconstriction Negative Regulation Of Transmission Of Nerve Impulse Transmembrane Transport ERK1 And ERK2 Cascade Protein Kinase C Signaling Negative Regulation Of Release Of Cytochrome C From Mitochondria
Pathways			Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) G alpha (q) signalling events Signaling by GPCR Vasopressin-like receptors G alpha (s) signalling events Vasopressin regulates renal water homeostasis via Aquaporins Class A/1 (Rhodopsin-like receptors) Metabolic disorders of biological oxidation enzymes GPCR ligand binding Aquaporin-mediated transport SLC-mediated transmembrane transport Transport of organic anions G alpha (q) signalling events GPCR downstream signaling Peptide ligand-binding receptors Gastrin-CREB signalling pathway via PKC and MAPK Transport of vitamins, nucleosides, and related molecules BMAL1:CLOCK,NPAS2 activates circadian gene expression
Drugs
Diseases
GWAS		Breast cancer ( 23535729)
Protein-Protein Interactions		14 interactors: AVP BZRAP1 DGCR6 DIP2A DLX5 GRN HOXC8 MSX1 MSX2 MVP NCOA2 PARK2 PIK3R1 XRCC6	8 interactors: AVPR1A AVPR1B AVPR2 CRYAB DLX2 KMT2A OXTR TXNDC17
Entrez ID		1746	551
HPRD ID		00527	01891
Ensembl ID		ENSG00000115844	ENSG00000101200
Uniprot IDs		Q07687 Q53QU7	P01185
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Mesenchymal Cell Apoptotic Process Embryonic Nail Plate Morphogenesis Activation Of Meiosis Regulation Of Transcription From RNA Polymerase II Promoter BMP Signaling Pathway Involved In Heart Development Negative Regulation Of Cellular Metabolic Process Nail Development Positive Regulation Of Gene Expression BMP Signaling Pathway Hyperosmotic Salinity Response Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Skeletal System Morphogenesis Regulation Of DNA Binding Protein Stabilization Negative Regulation Of Transcription Regulatory Region DNA Binding Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Multicellular Organismal Development Bone Morphogenesis Positive Regulation Of Meiotic Nuclear Division Negative Regulation Of Release Of Cytochrome C From Mitochondria Endocardial Cushion Formation Negative Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Regulation Of Protein Stability Hyperosmotic Response Endocardial Cushion Morphogenesis Regulation Of Transcription Regulatory Region DNA Binding Regulation Of Apoptotic Process Embryonic Limb Morphogenesis Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Signaling Cardiac Epithelial To Mesenchymal Transition Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Regulation Of Cell Death Transcription, DNA-templated Limb Morphogenesis Developmental Process Negative Regulation Of Cell Death Negative Regulation Of Mitochondrion Organization RNA Biosynthetic Process Organ Morphogenesis Signal Transduction Involved In Regulation Of Gene Expression Signaling Limb Development Face Morphogenesis	Regulation Of Systemic Arterial Blood Pressure By Vasopressin Positive Regulation Of Vasoconstriction Regulation Of Vasoconstriction Regulation Of Systemic Arterial Blood Pressure Positive Regulation Of Blood Pressure Regulation Of Blood Pressure Telencephalon Development Sperm Ejaculation Blood Circulation Response To Hormone Positive Regulation Of Systemic Arterial Blood Pressure Forebrain Development Maternal Behavior Response To Peptide Insemination Positive Regulation Of Cytosolic Calcium Ion Concentration Copulation Regulation Of Renal Sodium Excretion Cellular Response To Hormone Stimulus Cytosolic Calcium Ion Homeostasis Regulation Of Excretion Response To Organic Substance Brain Development Social Behavior Head Development Organ Development Response To Organonitrogen Compound Cellular Calcium Ion Homeostasis Chemical Homeostasis Calcium Ion Homeostasis Activation Of Phospholipase C Activity Mating Cellular Response To Organic Substance Positive Regulation Of Phospholipase C Activity Central Nervous System Development Negative Regulation Of Transport Cellular Metal Ion Homeostasis Positive Regulation Of Phospholipase Activity Cellular Cation Homeostasis G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Cellular Response To Drug Cellular Ion Homeostasis Regulation Of Phospholipase Activity Positive Regulation Of Lipase Activity Metal Ion Homeostasis Response To Steroid Hormone Cellular Chemical Homeostasis System Development Homeostatic Process Response To Estradiol
Tagcloud ?		acquiring adopt ascl1 assemble bhlh combinatorial derepression derivative diencephalic discrete dlx5 dlxs helt interneurons nuclei prethalamic prethalamus progenitor relaying rostral spatiotemporal specification specified surprisingly th thalamic thalamus tracing whereby	arginine ascending bath ca2 camp car ctal fluxes henle hypotonic isotonic limb lumen medullary mg2 mmol mol mtal nacl net pdte perfusion phospholipase reabsorption segments sensing thick transepithelial vasopressin
Tagcloud (Difference) ?		acquiring adopt ascl1 assemble bhlh combinatorial derepression derivative diencephalic discrete dlx5 dlxs helt interneurons nuclei prethalamic prethalamus progenitor relaying rostral spatiotemporal specification specified surprisingly th thalamic thalamus tracing whereby	arginine ascending bath ca2 camp car ctal fluxes henle hypotonic isotonic limb lumen medullary mg2 mmol mol mtal nacl net pdte perfusion phospholipase reabsorption segments sensing thick transepithelial vasopressin
Tagcloud (Intersection) ?