DLX2 and MSX1

Number of citations of the paper that reports this interaction (PubMedID 9111364)
41

Data Source:
BioGRID (two hybrid)

		DLX2	MSX1
Description		distal-less homeobox 2	msh homeobox 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Nuclear Periphery
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Single-stranded RNA Binding Protein Binding Sequence-specific Double-stranded DNA Binding	Transcription Cis-regulatory Region Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific P53 Binding DNA Binding Protein Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Notch Signaling Pathway Brain Development Proximal/distal Pattern Formation Neuroblast Differentiation Subpallium Development Hippocampus Development Olfactory Bulb Development Forebrain Neuron Differentiation Cerebral Cortex GABAergic Interneuron Differentiation Cerebral Cortex GABAergic Interneuron Fate Commitment Cell Differentiation Odontogenesis Of Dentin-containing Tooth Positive Regulation Of Cell Differentiation Negative Regulation Of Notch Signaling Pathway Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Photoreceptor Cell Differentiation Embryonic Cranial Skeleton Morphogenesis Embryonic Skeletal System Development Oligodendrocyte Differentiation Negative Regulation Of Oligodendrocyte Differentiation Branching Morphogenesis Of A Nerve Cartilage Development GABAergic Neuron Differentiation Positive Regulation Of Amacrine Cell Differentiation	Negative Regulation Of Transcription By RNA Polymerase II Cell Morphogenesis In Utero Embryonic Development Epithelial To Mesenchymal Transition Heart Morphogenesis Cardiac Conduction System Development Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Heart Development Muscle Organ Development Negative Regulation Of Cell Population Proliferation Animal Organ Morphogenesis Anterior/posterior Pattern Specification Mesenchymal Cell Proliferation Negative Regulation Of Gene Expression Pituitary Gland Development Signal Transduction Involved In Regulation Of Gene Expression Negative Regulation Of Cell Growth Embryonic Limb Morphogenesis BMP Signaling Pathway Positive Regulation Of BMP Signaling Pathway Forebrain Development Midbrain Development Protein Localization To Nucleus Embryonic Forelimb Morphogenesis Embryonic Hindlimb Morphogenesis Embryonic Nail Plate Morphogenesis Middle Ear Morphogenesis Odontogenesis Of Dentin-containing Tooth Odontogenesis Regulation Of Odontogenesis Positive Regulation Of Odontogenesis Embryonic Digit Morphogenesis Negative Regulation Of Apoptotic Process Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Nose Development Positive Regulation Of Cell Cycle Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Embryonic Morphogenesis Inner Ear Development Stem Cell Differentiation Protein Stabilization Negative Regulation Of Striated Muscle Cell Differentiation Cartilage Development Roof Of Mouth Development Face Morphogenesis Bone Morphogenesis Cartilage Morphogenesis Mammary Gland Epithelium Development Cell Surface Receptor Signaling Pathway Involved In Heart Development Cellular Response To Nicotine Activation Of Meiosis Mesenchymal Cell Apoptotic Process Negative Regulation Of Odontoblast Differentiation Positive Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Positive Regulation Of Mesenchymal Cell Apoptotic Process
Pathways			Specification of the neural plate border
Drugs
Diseases			Isolated orofacial clefts, including: Cleft lip with or without cleft palate; Cleft palate Tooth and nail syndrome; Witkop syndrome Tooth agenesis; Hypodontia
GWAS		Breast cancer ( 23535729) Food allergy ( 29030101) Peanut allergy ( 29030101)	Allergic disease (asthma, hay fever or eczema) ( 29083406) Breast cancer and/or colorectal cancer ( 29698419) Congenital heart disease ( 23708191) Electrocardiographic conduction measures ( 19389651) Nonsyndromic cleft lip with cleft palate ( 28232668)
Interacting Genes		14 interacting genes: AVP DGCR6 DIP2A DLX5 GRN HOXC8 MSX1 MSX2 MVP NCOA2 PIK3R1 PRKN TSPOAP1 XRCC6	25 interacting genes: CREBBP DLX2 DLX5 HOXC8 ING4 LHX2 MED19 MSX2 NMNAT1 PAX3 PAX9 PIAS1 POU2F1 RBPMS RGS7 SP1 SUMO1 SUMO2 TAF1 TBP TLE1 TLE2 TLE4 TLE5 TP53
Entrez ID		1746	4487
HPRD ID		00527	00866
Ensembl ID		ENSG00000115844	ENSG00000163132
Uniprot IDs		Q07687 Q53QU7 X5D7D8	P28360
PDB IDs
Enriched GO Terms of Interacting Partners?		Bone Morphogenesis Embryonic Nail Plate Morphogenesis Cell Surface Receptor Signaling Pathway Involved In Heart Development Activation Of Meiosis Positive Regulation Of Mesenchymal Cell Apoptotic Process Locomotory Behavior Regulation Of Primary Metabolic Process Negative Regulation Of Programmed Cell Death Regulation Of Macromolecule Metabolic Process Negative Regulation Of Apoptotic Process Transcription Cis-regulatory Region Binding Embryonic Limb Morphogenesis Animal Organ Morphogenesis BMP Signaling Pathway Transcription Regulator Complex Protein Stabilization Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Mammary Gland Epithelium Development Mesenchymal Cell Apoptotic Process Negative Regulation Of Metabolic Process Positive Regulation Of Meiotic Nuclear Division Cardiac Conduction System Development Limb Morphogenesis Response To Salt Stress Cellular Homeostasis Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Metabolic Process Regulation Of Cell Population Proliferation Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Protein Stability Positive Regulation Of Meiotic Cell Cycle Regulation Of Transcription By RNA Polymerase II Embryonic Hindlimb Morphogenesis Cardiac Epithelial To Mesenchymal Transition Positive Regulation Of Transcription By RNA Polymerase II Face Morphogenesis Anterior/posterior Pattern Specification Embryonic Forelimb Morphogenesis Negative Regulation Of DNA-templated Transcription Negative Regulation Of Macromolecule Metabolic Process Regulation Of Meiotic Nuclear Division Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Metabolic Process Regulation Of Cell Communication Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Positive Regulation Of Developmental Process Hindlimb Morphogenesis Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Negative Regulation Of Actin Filament Bundle Assembly	Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Negative Regulation Of DNA-templated Transcription Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of RNA Biosynthetic Process Regulation Of Primary Metabolic Process Chromatin Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Negative Regulation Of RNA Metabolic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Nucleus Regulation Of Macromolecule Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Metabolic Process Nucleoplasm Transcription Regulator Complex Transcription Cis-regulatory Region Binding Transcription Corepressor Activity Negative Regulation Of Transcription By RNA Polymerase II Animal Organ Morphogenesis RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Positive Regulation Of Transcription Initiation By RNA Polymerase II RNA Polymerase II Core Promoter Sequence-specific DNA Binding Positive Regulation Of DNA-templated Transcription Initiation Regulation Of Transcription Initiation By RNA Polymerase II DNA-binding Transcription Factor Binding Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of DNA-templated Transcription Initiation RNA Polymerase II-specific DNA-binding Transcription Factor Binding Presynaptic Cytosol Postsynaptic Cytosol
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