CNKSR2 and DLG2

Number of citations of the paper that reports this interaction (PMID 16637659)
18

Data Source:
HPRD (in vitro)

		CNKSR2	DLG2
Gene Name		connector enhancer of kinase suppressor of Ras 2	discs, large homolog 2 (Drosophila)
Image
Gene Ontology Annotations	Cellular Component	Golgi Apparatus Plasma Membrane Neuron Projection Neuronal Cell Body Postsynaptic Membrane Extracellular Vesicular Exosome	Plasma Membrane Voltage-gated Potassium Channel Complex Ionotropic Glutamate Receptor Complex Postsynaptic Density Membrane Basolateral Plasma Membrane Cell Junction Juxtaparanode Region Of Axon Postsynaptic Membrane
	Molecular Function	Identical Protein Binding	Guanylate Kinase Activity Protein Binding Ionotropic Glutamate Receptor Binding
	Biological Process	Regulation Of Signal Transduction	Synaptic Transmission Nervous System Development Negative Regulation Of Phosphatase Activity Sensory Perception Of Pain Receptor Clustering Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Nucleotide Phosphorylation Receptor Localization To Synapse
Pathways
Drugs
Diseases
GWAS			Obesity-related traits ( 23251661) Parkinson's disease ( 17052657) Phospholipid levels (plasma) ( 22359512) Protein quantitative trait loci ( 18464913) Wilms tumor ( 22544364)
Protein-Protein Interactions		12 interactors: DLG1 DLG2 DLG3 DLG4 INADL LRRC7 RALA RGS3 SHANK3 SNTA1 TJP1 TNIK	40 interactors: ABCA1 ATP2B2 ATP2B4 CACNG2 CNKSR2 CRIPT DLG1 DLG4 DLGAP1 ERBB4 FASLG FZD1 FZD4 FZD7 GLS2 GRID1 GRID2 GRIN1 GRIN2A GRIN2B GRIN2D GUCY1A2 KCNA4 KCNJ12 KCNJ2 KCNJ4 KHDRBS1 KIF1B LIN7A LRP2 MAP1A MAPK12 NLGN1 NLGN2 NLGN3 NOS1 SCN4A SCN5A SEMA4C WNT3A
Entrez ID		22866	1740
HPRD ID		06473	04663
Ensembl ID		ENSG00000149970	ENSG00000150672
Uniprot IDs		B3KPN2 Q8WXI2	B7Z2T4 E9PN83 Q15700
PDB IDs		2EAN 3BS5	2BYG 2HE2
Enriched GO Terms of Interacting Partners?		Receptor Localization To Synapse Receptor Clustering Protein Localization To Synapse Membrane Organization Protein Localization To Membrane Nucleotide Phosphorylation Establishment Or Maintenance Of Apical/basal Cell Polarity Cell-cell Signaling Alpha-amino-3-hydroxy-5-methyl-4-isoxazole Propionate Selective Glutamate Receptor Clustering Synaptic Transmission Regulation Of Membrane Potential Dendritic Spine Morphogenesis Cellular Protein Localization Vocalization Behavior Cell-cell Junction Assembly Cellular Localization Dendritic Spine Development Regulation Of Ion Transmembrane Transport Dendritic Spine Organization Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Synapse Organization Cortical Actin Cytoskeleton Organization Response To External Stimulus Postsynaptic Membrane Organization Establishment Or Maintenance Of Cell Polarity Phosphorylation Cortical Cytoskeleton Organization Signaling Cellular Component Assembly Regulation Of Long-term Neuronal Synaptic Plasticity Protein Localization Cytoskeleton Organization Nucleotide Metabolic Process Cell Junction Assembly Cell Communication Cell Projection Organization Positive Regulation Of Excitatory Postsynaptic Membrane Potential Cell Morphogenesis Involved In Neuron Differentiation Cell-cell Junction Organization Chemotaxis Actin Cytoskeleton Organization Regulation Of Sodium Ion Transmembrane Transport Regulation Of Ion Transport Neuron Projection Morphogenesis Social Behavior Actin Filament-based Process Nucleobase-containing Small Molecule Metabolic Process Positive Regulation Of Membrane Potential Tight Junction Assembly Cell Morphogenesis Involved In Differentiation	Cell-cell Signaling Synaptic Transmission Membrane Depolarization Regulation Of Ion Transmembrane Transport Signaling Cell Communication Regulation Of Membrane Potential Regulation Of Ion Transport Regulation Of Excitatory Postsynaptic Membrane Potential Regulation Of Postsynaptic Membrane Potential Neuron-neuron Synaptic Transmission Neuromuscular Process Ionotropic Glutamate Receptor Signaling Pathway Synaptic Transmission, Glutamatergic Ion Transmembrane Transport Neurological System Process Regulation Of Signaling Glutamate Receptor Signaling Pathway Startle Response Ion Transport Regulation Of Synaptic Transmission Positive Regulation Of Excitatory Postsynaptic Membrane Potential Regulation Of Signal Transduction Negative Regulation Of Adrenergic Receptor Signaling Pathway Involved In Heart Process Regulation Of Sodium Ion Transmembrane Transport Nervous System Development Metal Ion Transport Transmembrane Transport Positive Regulation Of Membrane Potential Transport Negative Regulation Of Adrenergic Receptor Signaling Pathway Neuron Differentiation Cation Transmembrane Transport Protein Localization To Synapse Positive Regulation Of Transport Neurogenesis Behavior Regulation Of Alpha-amino-3-hydroxy-5-methyl-4-isoxazole Propionate Selective Glutamate Receptor Activity Regulation Of Receptor Activity Metencephalon Development Regulation Of Respiratory Gaseous Exchange Regulation Of Cellular Process Regulation Of Sodium Ion Transport Generation Of Neurons Postsynaptic Membrane Organization Regulation Of Adrenergic Receptor Signaling Pathway Regulation Of Ion Transmembrane Transporter Activity Regulation Of Transmembrane Transporter Activity Cell Morphogenesis Involved In Differentiation Postsynaptic Membrane Assembly
Tagcloud ?			17q12 apical basolateral defining disc discs dlg3 encodes germline guanylate homology identity imaginal lethal mediating member neoplastic oncogene organization originally overgrowth p55 phosphoprotein polarity q21 recessive segment similarity
Tagcloud (Difference) ?			17q12 apical basolateral defining disc discs dlg3 encodes germline guanylate homology identity imaginal lethal mediating member neoplastic oncogene organization originally overgrowth p55 phosphoprotein polarity q21 recessive segment similarity
Tagcloud (Intersection) ?