CNKSR2 and LRRC7

Number of citations of the paper that reports this interaction (PubMedID 12390249)
0

Data Source:
HPRD (in vivo, two hybrid, in vitro)

		CNKSR2	LRRC7
Description		connector enhancer of kinase suppressor of Ras 2	leucine rich repeat containing 7
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Postsynaptic Density Membrane Neuronal Cell Body Postsynaptic Membrane Extracellular Exosome Glutamatergic Synapse Extrinsic Component Of Postsynaptic Density Membrane	Extracellular Region Cytoplasm Cytosol Adherens Junction Postsynaptic Density Basolateral Plasma Membrane Specific Granule Lumen Axon Initial Segment Synapse Postsynaptic Membrane
	Molecular Function	Protein Binding Protein Kinase Binding Identical Protein Binding	Protein Binding Protein Kinase Binding
	Biological Process	Regulation Of Signal Transduction Intracellular Signal Transduction Postsynaptic Specialization Organization Postsynapse Organization	Positive Regulation Of Neuron Projection Development Receptor Clustering Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Cell-cell Adhesion Neurotransmitter Receptor Transport, Endosome To Postsynaptic Membrane
Pathways		MAP2K and MAPK activation Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF1 fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Signaling downstream of RAS mutants Signaling by RAF1 mutants
Drugs
Diseases
GWAS		Bipolar disorder ( 31043756) Educational attainment (years of education) ( 30038396) Schizophrenia ( 25056061) Type 2 diabetes ( 30718926)	Adventurousness ( 30643258) Attention deficit hyperactivity disorder ( 21784300) Body mass index ( 24348519) Cognitive decline rate in late mild cognitive impairment ( 26252872) Hypertension risk in short sleep duration ( 22322875) Obesity-related traits ( 23251661) Orofacial clefts ( 22419666) Psoriasis ( 25939698) Type 2 diabetes ( 31049640)
Interacting Genes		14 interacting genes: DLG1 DLG2 DLG3 DLG4 LRRC7 PATJ RALA RGS3 SHANK3 SMURF2 SNTA1 TJP1 TNIK YAP1	18 interacting genes: ACTN2 ACTN4 ADGRB1 CAMK2A CAMK2G CDH2 CNKSR2 CTNND2 EPS15L1 ERBB2 ERBB3 ERBB4 HOMER3 HOMEZ NQO2 PPP1R9B TOR1A VANGL2
Entrez ID		22866	57554
HPRD ID		06473	09930
Ensembl ID		ENSG00000149970	ENSG00000033122
Uniprot IDs		A0A2R8Y622 A0A2R8Y700 A0A2R8Y7A1 A0A2U3TZH5 B3KPN2 Q8WXI2	A0A075B6E9 A0A494C1A4 B1AKT2
PDB IDs		2EAN 3BS5
Enriched GO Terms of Interacting Partners?		Receptor Clustering Establishment Or Maintenance Of Apical/basal Cell Polarity Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Ionotropic Glutamate Receptor Binding Protein Localization To Cell Junction Receptor Localization To Synapse Protein Localization To Synapse Establishment Or Maintenance Of Cell Polarity Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Neuromuscular Junction Adherens Junction Bicellular Tight Junction Localization Within Membrane Protein Localization To Membrane Cell Junction Basolateral Plasma Membrane Postsynaptic Density Kinase Binding Postsynaptic Density Membrane Cell-cell Adhesion Protein Localization To Postsynaptic Membrane Protein Localization To Postsynapse Neuron Projection Plasma Membrane AMPA Glutamate Receptor Clustering Regulation Of Cell Projection Organization Anchoring Junction Neuron Spine Synaptic Membrane Protein Kinase Binding Protein-containing Complex Localization GMP Kinase Activity Regulation Of Anatomical Structure Morphogenesis Ribonucleoside Diphosphate Metabolic Process Cell Adhesion GDP Metabolic Process Nucleoside Diphosphate Metabolic Process Regulation Of Biological Quality Cytosol Juxtaparanode Region Of Axon Neurotransmitter-gated Ion Channel Clustering Cell Junction Assembly Cellular Response To Potassium Ion Nervous System Development Cellular Localization Chemical Synaptic Transmission Dendritic Spine Morphogenesis Postsynaptic Density Organization Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Regulation Of Plasma Membrane Bounded Cell Projection Organization	Postsynaptic Density Cortical Actin Cytoskeleton Regulation Of Cell Communication Regulation Of Signaling Identical Protein Binding Protein Localization To Cell Periphery Regulation Of Protein Localization Peripheral Nervous System Development ERBB3:ERBB2 Complex ERBB2 Signaling Pathway Neuregulin Receptor Activity Basolateral Plasma Membrane Regulation Of Protein Localization To Cell Surface Regulation Of Cellular Localization Calcium- And Calmodulin-dependent Protein Kinase Complex Protein Kinase Activity ErbB-3 Class Receptor Binding ERBB2-ERBB4 Signaling Pathway Dendritic Spine Glutamatergic Synapse Cellular Response To Epidermal Growth Factor Stimulus Cell Projection Response To Epidermal Growth Factor Regulation Of Metal Ion Transport Intracellular Protein Localization Synapse Regulation Of Protein Localization To Membrane ERBB2-ERBB3 Signaling Pathway ERBB3 Signaling Pathway ERBB4 Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Basal Plasma Membrane Regulation Of Signal Transduction Anchoring Junction Postsynaptic Actin Cytoskeleton Cell Junction Regulation Of Monoatomic Ion Transport Plasma Membrane Wound Healing Cell Surface Receptor Signaling Pathway ERBB Signaling Pathway Cell Projection Organization Cell Junction Organization Dendrite Regulation Of Transport Neuron Projection Development Synapse Organization Pseudopodium Postsynaptic Density Membrane Schwann Cell Development
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